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Exploration of the effects of Tai Chi practice on lower limb corticomuscular coherence during balance-demanding virtual reality conditions in older adults
Tai Chi practice has been widely adopted to improve balance and prevent falls in older adults. However, the neural mechanisms underlying the benefits of Tai Chi are difficult to evaluate during traditional balance assessments. The goal of this study was to evaluate the effects of Tai Chi and…
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α-klotho as a biomarker of amyloid β levels in the cerebrospinal fluid
IntroductionCSF α-klotho levels might affect Aβ40, Aβ42, and the Aβ42/40 ratio in the cerebrospinal fluid (CSF).MethodsCSF α-klotho was assayed in ovariectomized rhesus macaques (NHPs) maintained on a Western-style diet (WSD) to assess the effect of estrogen hormone therapy (HT). CSF and serum…
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Tau and tauopathies across primate species: implications for modeling neurodegenerative disorders
Tauopathies are neurodegenerative disorders characterized by the abnormal accumulation and aggregation of hyperphosphorylated tau protein. They can be primary or secondary depending on whether tau inclusions are the predominant pathology (e.g.: frontotemporal dementia related to tau) or are found…
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Modeling and validation of wearable sensor-based gait parameters in Parkinson’s disease patients with cognitive impairment
BackgroundCognitive impairment is a common non-motor symptom of Parkinson’s disease (PD) that significantly impacts patients’ quality of life and disease progression. Despite its clinical importance, the underlying mechanisms linking motor and cognitive dysfunction in PD remain poorly understood…
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Artikel Jurnal
Lifespan brain age prediction based on multiple EEG oscillatory features and sparse group lasso
IntroductionThe neural dynamics underlying cognition and behavior change greatly during the lifespan of brain development and aging. EEG is a promising modality due to its high temporal resolution in capturing neural oscillations. Precise prediction of brain age (BA) based on EEG is crucial to…
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Artikel Jurnal
Sex differences in the outcomes of modifiable lifestyle factors for cognitive aging: neuroinflammation and microglia as key underlying mechanisms
Microglia are the resident immune cells of the brain. Over the past two decades, they have been shown to play critical roles throughout life. Microglia are now considered to be important for brain formation, maturation, activity and plasticity, with outcomes on behavior and other cognitive domains…
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Artikel Jurnal
Protocol of a randomized, single-blind, controlled trial of an 18-month, home-based, high-intensity, exercise intervention in older, cognitively unimpaired APOE ε4 carriers
BackgroundThe World Health Organization highlighted the potential protective role of exercise against cognitive decline, all-cause dementia, Alzheimer’s disease (AD), and vascular dementia in healthy individuals. We have previously shown that exercise is particularly beneficial for older…
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Artikel Jurnal
Alterations in brain function in patients with post-stroke cognitive impairment: a resting-state functional magnetic resonance imaging study
BackgroundCognitive impairment is a common dysfunction following stroke, significantly affecting patients’ quality of life. Studies suggest that post-stroke cognitive impairment (PSCI) may be related to neural activity in specific brain regions. However, the neural mechanisms remain to be further…
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Artikel Jurnal
Simulated driving behavior over the adult age span
BackgroundMotor vehicle accidents remain a leading cause of accidental death worldwide. Death and injury rates are particularly high for both young inexperienced drivers and elderly drivers. Understanding the behavioral changes that are associated with maturation and aging could inform assessments…
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Applications of event-related potentials in Alzheimer’s disease: a systematic review and analysis
The prevalence of Alzheimer’s disease (AD) has been increasing continuously, representing a major issue for public welfare. Detecting cognitive impairment due to AD at its early stages is an urgent prerequisite for therapeutic treatment to slow or halt disease progression before major brain damage…
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Artikel Jurnal
Mirodenafil improves cognitive function by reducing microglial activation and blood–brain barrier permeability in ApoE4 KI mice
IntroductionAlzheimer’s disease (AD) has significant public health concerns in the aging society. AD can compromise brain function and lead to severe neurological abnormalities associated with dementia. The human Apolipoprotein E (ApoE4) gene is a strong risk factor for AD. However, comprehensive…
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Artikel Jurnal
Meta-analysis of the effects of multi-component exercise on cognitive function in older adults with cognitive impairment
Exercise has been widely recognized as an effective regimen in mitigating cognitive decline. However, the effect of multi-component exercise (i.e., combination of two or more types of exercise) on cognitive function and its subdomains in older adults remains unclear. This meta-analysis aimed to…
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Artikel Jurnal
Cerebrospinal fluid levels of tumour necrosis factor-α and its receptors are not associated with disease progression in Alzheimer’s disease
IntroductionTumour necrosis factor-α (TNF-α) is a proinflammatory cytokine implicated in the regulation of innate and adaptive immunity. Two receptors exist for TNF-α: TNF receptors 1 (TNFR-1) and 2 (TNFR-2). TNFR-1 and TNFR-2 have been reported to be involved in pleiotropic functions. Multiple…
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Association between hemoglobin-to-red blood cell distribution width ratio and cognitive function in older US adults: a cross-sectional study based on the NHANES 2011–2014
IntroductionThe hemoglobin-to-red blood cell distribution width ratio (HRR) is acknowledged as a promising new prognostic biomarker. Nevertheless, investigations into its connection with cognitive function have yielded unclear results.AimThis study aimed to investigate the association between the…
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Blood essential trace elements and Alzheimer’s disease biomarkers in midlife
BackgroundAlzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, impacting millions globally. Essential trace elements are implicated in key age-related physiologic processes but have not been fully examined with respect to AD etiology. This study…
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Bibliometric analysis of global research on PD-L1/PD-1 pathway and neurodegenerative diseases over the last two decades (2004–2023)
BackgroundProgrammed death receptor 1 (PD-1), encoded by the PDCD1 gene, functions as a pivotal immunosuppressive molecule. Neurodegenerative diseases (NDDs) encompass a diverse array of neurological disorders that adversely impact the lives of millions of individuals globally. The current study…
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Association of neutrophil-percentage-to-albumin ratio with mortality in older stroke survivors
BackgroundThe neutrophil-percentage-to-albumin ratio (NPAR) functions as an integrative marker representing inflammatory response and nutritional health. However, its association with mortality in elderly stroke survivors has not been explored.MethodsThis cohort study analyzed data from 1,026…
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Dysregulated calcium signaling in the aged primate association cortices: vulnerability to Alzheimer’s disease neuropathology
The common, late onset form of Alzheimer’s disease (AD) selectively impacts higher brain circuits, with tau pathology and neurodegeneration preferentially afflicting glutamatergic neurons in the limbic and association cortices. Understanding this selective vulnerability may help reveal the etiology…
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Younger adult brain utilizes interhemispheric strategy via ipsilateral dorsal premotor cortex for fine control of dexterous finger movements, unlike the aging brain
IntroductionThis study investigated how healthy, right-handed younger adults utilize the typically suppressed ipsilateral sensorimotor cortices [particularly, the dorsal premotor cortex (PMd), primary motor cortex (M1), primary somatosensory cortex (S1), and superior parietal cortex of Area 2] to…
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Artikel Jurnal
The glymphatic system as a therapeutic target: TMS-induced modulation in older adults
While repetitive transcranial magnetic stimulation (rTMS) is a promising neuromodulatory intervention for cognitive impairment, its effects on the glymphatic system remain unexplored in clinical populations. Deficient glymphatic clearance has emerged as a central feature of neurodegenerative…
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