8.223 hasil
Menampilkan 101–120 · 3,85 detik · RSS
-
Artikel Jurnal
Association of gait, balance, and handgrip strength with cognitive performance in hospitalized older adults: a retrospective analysis
BackgroundSensorimotor impairments—such as reduced gait speed, diminished balance, and lower muscle strength—are common in older adults and have been suggested as early markers of cognitive decline. However, evidence from real-world hospital settings remains limited. This study investigated the…
-
Artikel Jurnal
Age-related changes in static and dynamic postural balance performance
BackgroundAge-related changes in the neuromuscular and sensory systems compromise the control of balance and stability. Static balance assessments may overlook deficits that appear when coping with unexpected perturbations. This cross-sectional study aimed to compare static and dynamic balance…
-
Artikel Jurnal
TAS2R38 taster variants-linked MGAM expression in Alzheimer’s disease: a novel target for precision drug repurposing
IntroductionTAS2R38 is a taste receptor gene located on human chromosome 7 that influences sensitivity to bitter tastes and has been implicated in innate immunity, glucose level, and human longevity. However, its potential association with Alzheimer’s Disease (AD) has not been explored. Identifying…
-
Artikel Jurnal
Diet, gut microbiome, and cognition in neurodegeneration: a review and methodological framework
The gut microbiome influences brain function through the gut-brain axis via synthesis of neurotransmitters, production of metabolites affecting epithelial barrier integrity and immune modulation and signaling through the vagus nerve. In humans, microbiome diversity reflects healthy aging and…
-
Artikel Jurnal
Targeting the astrocytic metabolic cascade in Alzheimer’s disease: mechanisms, challenges and opportunities
Alzheimer’s disease (AD), a pressing global public health challenge, is underpinned by multifaceted pathogenic mechanisms. While traditional research has centered on amyloid-β deposition and tau hyperphosphorylation, emerging evidence reveals that metabolic perturbations play a pivotal role in the…
-
Artikel Jurnal
Privacy and personalisation: predicting Parkinson’s disease severity from real-world gait with federated learning
IntroductionCloud-based artificial intelligence (AI) combined with smart-health technology presents a powerful tool to passively monitor disease severity. However, current methods raise privacy concerns as they require transmitting patient data to the cloud. A potential solution is Federated…
-
Artikel Jurnal
Neuropsychological aspects of impulse control disorders in Parkinson’s disease
Impulse control disorders (ICDs), such as excessive gambling, compulsive sexual behavior, binge eating, compulsive shopping as well as punding, and the dopamine dysregulation syndrome, may arise as a debilitating neuropsychiatric complication in Parkinson’s disease (PD). Although the…
-
Artikel Jurnal
Prolonged intermittent theta burst stimulation enhances hippocampal plasticity via GluN2A-mediated signaling
BackgroundIntermittent theta burst stimulation (iTBS) is increasingly explored as a non-invasive neuromodulatory approach capable of inducing long-lasting plasticity with potential therapeutic value in age-related neurological and psychiatric conditions. However, the cellular and molecular…
-
Artikel Jurnal
Immunosenescence and its impact on ischemic stroke risk and outcomes in older adults: a systematic review
BackgroundAge is a major risk factor for ischemic stroke (IS), with immunosenescence–age-related immune system dysfunction - contributing to worse outcomes. Immunosenescence impairs immune responses, heightens inflammation, and increases susceptibility to infections, all of which affect stroke…
-
Artikel Jurnal
Brain insulin resistance: a key pathological hub linking metabolic and neuropsychiatric comorbidities
The high rate of comorbidity between metabolic diseases and neuropsychiatric disorders suggests a shared underlying pathogenic mechanism. However, the biological basis of this relationship remains unclear. This study aims to clarify the role of brain insulin resistance (BIR) in linking metabolic…
-
Artikel Jurnal
Novel applications of machine learning and computational neuroscience models to neuroimaging in Parkinson’s disease and related disorders
Purpose of reviewParkinsonian syndromes are a heterogeneous group of neurodegenerative diseases that pose challenges in early diagnosis, differentiation, and pathophysiological understanding. The objective of this review is to summarize recent contributions of computational models combined with…
-
Artikel Jurnal
Prediction of treatment responsiveness to home-based transcranial photobiomodulation (tPBM) intervention for cognitive decline using fNIRS concurrently recorded during tPBM
IntroductionTranscranial Photobiomodulation (tPBM) has attracted growing interest as an intervention to mitigate cognitive decline in older adults. However, some individuals do not respond to tPBM. This study explored the feasibility of predicting treatment responsiveness using functional…
-
Artikel Jurnal
Gut microbiota and brain aging: a comparative review of African and western populations
As the population ages, cognitive decline and neurodegenerative diseases have become major public health concerns. The human gut microbiota plays a major role in regulating neurodevelopment, neuroinflammation, and cognitive decline through the gut-brain axis. Emerging evidence reveals a possible…
-
Artikel Jurnal
Heat shock proteins (Hsp70 and Hsp90) in neurodegeneration: pathogenic roles and therapeutic potential
The maintenance of protein homeostasis is essential for neuronal survival and function; however, it progressively declines with age, predisposing the brain to neurodegenerative diseases. Molecular chaperones Hsp70 and Hsp90 are key guardians of proteostasis, pivotally regulating protein folding…
-
Artikel Jurnal
Cognitive function is associated with the progression of non-tremor motor symptoms in Parkinson’s disease
BackgroundParkinson’s disease (PD) is characterized by motor impairment which consists of tremor and non-tremor symptoms. Cognitive function may overlap with specific aspects of voluntary movement and action initiation. This study aims to investigate associations between global cognition and the…
-
Artikel Jurnal
Lower hippocampal volume partly mediates the association between rs6859 in the NECTIN2 gene and Alzheimer’s disease: new findings from causal mediation analysis of ADNI data
IntroductionAlzheimer’s disease (AD) is a complex disorder influenced by many factors. The rs6859 polymorphism in the NECTIN2 gene has been consistently linked to AD risk. The NECTIN2 is involved in vulnerability to infections, which could contribute to neurodegeneration. We hypothesized that…
Menampilkan maksimal 50 halaman. Persempit pencarian dengan filter untuk hasil yang lebih spesifik.