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Cortical hemodynamic responses in older stroke patients during a walking-based Stroop dual task: a functional near-infrared spectroscopy study
ObjectivesThis study aimed to investigate cortical hemodynamic responses in older stroke patients during a walking-based Stroop dual task using functional near-infrared spectroscopy (fNIRS).MethodsThirty-four stroke patients aged over 55 years performed three walking-based Stroop dual tasks while…
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Artikel Jurnal
Endogenous β-hydroxybutyrate and the risk of cognitive decline: a nested case-control study in the UK Biobank cohort
Introductionβ-hydroxybutyrate (BHB) has been linked to improved cognitive function via enhanced cerebral metabolism and anti-inflammatory effects. However, evidence on the relationship between endogenous plasma BHB levels and cognitive decline remains limited. This study investigated whether higher…
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Brain lipidomics for region-specific biomarker discovery in neurodegenerative diseases
BackgroundAlzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD) are progressive neurodegenerative diseases (NDs) characterized by chronic neuronal loss. The lack of effective treatments highlights the urgent need for reliable lipid biomarkers to enable diagnosis and…
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Insulin resistance (TyG index) and body mass index as metabolic biomarker combined with ApoE genotype to diagnose Alzheimer’s disease
BackgroundGrowing evidence suggests that both ApoE genotype and metabolic disturbances including insulin resistance (IR) and obesity constitute risk factors for Alzheimer’s disease (AD). However, large-scale studies investigating whether ApoE genotype interacts with metabolic abnormalities to…
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Artikel Jurnal
Systems-level molecular and immunological evidence identifies Th17/Treg modulation as a key mechanism of CRSJ’s neuroprotection in Parkinson’s disease
BackgroundParkinson’s disease (PD) is a progressive neurodegenerative disorder in which neuroinflammation plays a central role. Congrong Shujing Granules (CRSJ), a traditional Chinese medicine formula, have shown clinical benefits in PD, yet their immunomodulatory mechanisms remain…
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Artikel Jurnal
The genetic architecture of Parkinson's disease in Mexico: a systematic review
BackgroundDespite substantial advances in Parkinson's disease genomics, Latin American populations remain underrepresented in global genetic studies, limiting the generalizability of risk estimates and biological inference. Mexico, characterized by complex admixture patterns, represents a critical…
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Artikel Jurnal
Age-related decline in temporal sound processing: insights from envelope steepness map in the mouse auditory cortex
IntroductionSpectral information of speech sounds is spatially arranged from low to high frequencies in the auditory cortex, known as tonotopic maps. Recently, we identified an envelope steepness map encoding the rise-ramp steepness of sounds, which is located orthogonally to the tonotopic map…
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Artikel Jurnal
Toward an understanding of real-world mobility in Parkinson’s: insights from enhanced contextualisation using GPS-derived location and data-driven modeling of walking speed
IntroductionConventional clinical assessments do not fully capture how Parkinson’s disease (PD) affects mobility in daily life. Integrating digital mobility outcomes (DMOs) from wearable devices with GPS-derived contextual data could provide richer insight into real-world mobility, yet this…
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Artikel Jurnal
Association between frailty and cognitive impairment in elderly patients with acute cerebral infarction
BackgroundPost-stroke cognitive impairment is common in older patients, yet the interaction between frailty and cognition remains insufficiently characterized. Evidence using multidimensional frailty tools during hospitalization for acute cerebral infarction is limited, and domain-level cognitive…
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Increasing daily step count in mild cognitive impairment: a 12-month randomised controlled trial
IntroductionDespite numerous studies confirming the beneficial effects of physical activity on cognitive function, there is a lack of randomised controlled trials involving long-term, continuous monitoring of physical activity that assess the effect of step-based intervention on cognition-related…
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Artikel Jurnal
Computational gait analysis in the 3xTg-AD mouse model: evidence of progressive alterations in locomotor coordination
IntroductionGait alterations have been proposed as functional indicators of neural dysfunction in Alzheimer's disease; however, their ability to capture disease-associated locomotor changes in preclinical models remains insufficiently characterized.MethodsIn this study, we applied a…
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Artikel Jurnal
A multimodal machine-learning diagnostic model for Alzheimer’s disease: integrating OCTA-derived retinal microvascular features and clinical variables
IntroductionAlzheimer’s disease (AD) lacks widely accessible, noninvasive approaches for the evaluation of AD remain limited. We developed a multimodal machine-learning model that integrates retinal microvascular features derived from optical coherence tomography angiography (OCTA) with clinical…
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Artikel Jurnal
Bibliometric analysis of dietary patterns in Parkinson’s disease: from Mediterranean diet to emerging trends
BackgroundParkinson’s disease (PD) is one of the fastest-growing neurological disorders. Treatments remain symptomatic, with no disease-modifying therapies available. Recent preclinical and epidemiological studies suggest that dietary patterns may influence PD pathology through the…
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Artikel Jurnal
Effects and safety of repetitive transcranial magnetic stimulation on cognitive outcomes in mild cognitive impairment: a systematic review and meta-analysis
BackgroundRepetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique that has been increasingly investigated as a potential treatment for mild cognitive impairment (MCI). However, its clinical efficacy remains uncertain due to heterogeneous findings across…
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Artikel Jurnal
A collaborative multi-view fusion framework with Deep Forest for multi-class diagnosis of Alzheimer’s disease
ObjectiveA key aspect of diagnosing Alzheimer’s disease (AD) is identifying mild cognitive impairment (MCI), a sensitive transitional stage between normal cognition (NC) and AD. We divided AD disease progression into three stages: NC, MCI, and AD according to severity. We used CoopLearning to…
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Artikel Jurnal
MAPK3 as a ferroptosis driver in excitatory neurons in Alzheimer’s disease: from genetic causal inference to in vivo functional validation
IntroductionAlzheimer’s disease (AD) is a progressive neurodegenerative disorder, and ferroptosis-an iron-dependent form of regulated cell death-has been increasingly implicated in AD-related neuronal loss. However, the causal relationship between specific ferroptosis-related genes and AD…
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Artikel Jurnal
Low-density lipoprotein cholesterol modulates amyloid-related entorhinal vulnerability and episodic memory performance in older adults
IntroductionCerebral amyloid-beta (Aβ) burden does not fully explain variation in Alzheimer’s disease (AD)-related brain structure and episodic memory. We examined whether circulating low-density lipoprotein cholesterol (LDL-C) modifies the cross-sectional statistical association between Aβ burden…
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Artikel Jurnal
Peroxisomes in Alzheimer’s disease: emerging mechanistic insights and therapeutic opportunities
Alzheimer’s disease (AD) is characterized by amyloid-β (Aβ) deposition, tau pathology, synaptic injury, neuroinflammation, oxidative stress, and disrupted organellar homeostasis. Peroxisomes maintain lipid and redox balance through very-long-chain fatty acid (VLCFA) β-oxidation, plasmalogen…
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Artikel Jurnal
Gut-brain immune dysregulation in Parkinson’s disease: a hypothesis-forming narrative review of trained immunity
Parkinson’s disease (PD) is increasingly understood as a multisystem disorder in which gastrointestinal dysfunction, immune remodeling, protein aggregation, and central neurodegeneration interact across the disease course. Although gut microbiota alterations are repeatedly reported in PD, taxonomic…
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