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Artikel Jurnal
Blood biomarkers and artificial intelligence: toward precision medicine in Alzheimer’s disease
The integration of blood-based biomarkers and artificial intelligence (AI) is revolutionizing the diagnostic landscape of Alzheimer’s disease (AD). In this paper, we synthesize recent advancements in the application of machine learning (ML) on blood biomarker analysis, evaluating their diagnostic…
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Artikel Jurnal
Association between atherogenic dyslipidemia and DBS-derived p-tau217 in older adults: evidence from SHARE DBS data
BackgroundAtherogenic dyslipidemia has been associated with adverse cognitive and dementia-related outcomes, but its relationship with Alzheimer’s disease-related blood biomarkers remains unclear.ObjectiveTo examine whether the atherogenic index of plasma (AIP) is associated with dried blood spot…
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A computational-first proof-of-concept for dual-function metal chelation and aggregate neutralization in an Aβ42 Drosophila model
Alzheimer’s disease (AD) pathology is amplified by a self-reinforcing metal–Aβ–ROS axis, in which redox-active Cu and Fe bound to Aβ N-terminal histidines catalyze Fenton-like ROS generation and accelerate aggregation. Existing single-target interventions – anti-amyloid antibodies, antioxidants…
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Artikel Jurnal
Multi-omics identification of novel biomarkers and therapeutic targets for Parkinson's disease: from transcriptome to drug interaction
IntroductionParkinson's disease (PD) is a progressive neurodegenerative disorder with limited therapeutic options. Acupuncture may serve as a complementary intervention, but its molecular mechanisms remain unclear. This study integrated bulk and single-cell transcriptomic datasets to identify…
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Artikel Jurnal
Epigenetic memory and allostatic integrity: a theoretical integration of the hierarchical-circular model using a longitudinal methylation signature of dementia
IntroductionThe Hierarchical-Circular Model of Biological Memory (HCM) proposes that dementia results from disrupted circular information flow across five levels: genetic, epigenetic, allostatic, PNEI network, and interoceptive. Allostatic integrity—the adaptive capacity for circular…
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Artikel Jurnal
Reconsideration of the DTI-ALPS index as a glymphatic surrogate: disease-specific findings in small vessel disease due to cerebral amyloid angiopathy or arteriolosclerosis
ObjectivesTo explore the disease-specific performance of diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) index in cerebral amyloid angiopathy (CAA) and arteriolosclerosis CSVD (aCSVD).MethodsWe retrospectively enrolled probable CAA or aCSVD patients who underwent 5.0T MRI…
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Artikel Jurnal
Olfactory impairment and probable REM sleep behavior disorder in Parkinson’s disease: clinical relevance to the single- and dual-hit hypotheses
BackgroundRapid eye movement (REM) sleep behavior disorder (RBD) and olfactory impairment are common prodromal features of Parkinson’s disease (PD), but the implications of their coexistence remain uncertain. The dual-hit hypothesis proposes concomitant olfactory and enteric involvement, whereas…
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Artikel Jurnal
Average performance and performance variability on a brief functional fine motor test reflect distinct behavioral constructs in aging
Prior work in older adults has developed a brief functional fine motor test, which involves repeated timed trials of an upper-limb task. Performance has been associated with global and domain-specific neuropsychological tests as well as putative markers of Alzheimer’s disease when scored using…
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Artikel Jurnal
Kinestesia: the prefrontal EEG response to a cognitive-motor intervention is graded by baseline cognitive status
BackgroundThis is a companion neurophysiological study (N = 19) to a recently published exploratory pilot of the Kinestesia intervention — combining therapeutic videogames, rhythmic gait, and sensory stimulation — in older adults spanning the cognitively healthy (HC, n = 10) to mild cognitive…
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Artikel Jurnal
Deep cervical lymphovenous reconstruction in Alzheimer’s disease: three target-defined interfaces with distinct mechanistic implications
Age-related impairment of brain solute clearance has been implicated in Alzheimer’s disease (AD), yet procedures described as deep cervical lymphovenous reconstruction do not necessarily target the same lymphatic structure. This review examines glymphatic exchange, meningeal lymphatic drainage…
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Artikel Jurnal
Global research trends and hotspots in blood-based biomarkers for Alzheimer’s disease: a bibliometric analysis
BackgroundBlood-based biomarkers (BBMs) are rapidly reshaping the diagnostic and translational landscape of Alzheimer’s disease (AD), offering a scalable alternative to cerebrospinal fluid (CSF) assays and positron emission tomography (PET). This paper aims to conduct bibliometric analysis on the…
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Artikel Jurnal
Persistent Alzheimer-related molecular dysregulation after cerebral ischemia: a hierarchical-circular hypothesis of impaired allostatic recovery
IntroductionGrowing evidence suggests a consistent association between brain ischemia and the subsequent development of Alzheimer’s disease (AD)-related molecular changes. Experimental and clinical studies have demonstrated that ischemic episodes trigger the overexpression of genes associated with…
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Artikel Jurnal
Age-related differences in behavioral and brain predictors of parkinsonism in autistic adults
Autistic adults experience lifelong motor differences and may have increased vulnerability to parkinsonism, yet behavioral and neuroanatomical correlates of motor challenges across adulthood remain poorly understood. We examined cross-sectional behavioral and motor-related brain region morphology…
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Artikel Jurnal
Muscle quality index combined with plasma metabolomics: enhancing risk stratification for post-stroke dementia
ObjectivePost-stroke dementia is a severe long-term stroke complication with heavy medical burdens, and early risk identification is critical. This study explored the association of muscle quality index (MQI) and plasma metabolomics with dementia among stroke survivors.MethodsThis study included…
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Artikel Jurnal
Clemastine alleviates Parkinson’s disease pathology by activating the AMPK/mTOR pathway and enhancing autophagic flux
Parkinson’s disease (PD) is a debilitating neurodegenerative disorder with no available cure, underscoring the urgent need for novel therapeutics. This study employed the comprehensive bioinformatic analyses and the experimental models to investigate the potential of clemastine (CLE) for PD…
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Multimodal neuroimaging and electrophysiological signatures in amnestic mild cognitive impairment with different amyloid-β deposition status: correlations with cognitive function and diagnostic value
BackgroundAmnestic mild cognitive impairment (aMCI) is a heterogeneous transitional cognitive state between normal aging and dementia. Aβ positivity elevates dementia conversion risk but does not equate to prodromal Alzheimer’s disease (AD), and not all Aβ-positive aMCI individuals progress to…
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Artikel Jurnal
Childhood trauma and cognitive decline in women: an empirical analysis of cognitive vulnerability in later life
Childhood trauma has lasted consequences for women’s cognitive health and this may contribute to memory decline and increased vulnerability to cognitive impairment in later life. A cross sectional study was carried out to assess the correlation between childhood trauma and cognitive status among 55…
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Artikel Jurnal
Olfactory context and memory across the adult lifespan: effects on mnemonic discrimination and olfactory function
Odor is a powerful contextual cue that can influence memory and is closely linked to brain regions involved in episodic memory, including the hippocampus. Age-related olfactory dysfunction is among the earliest behavioral changes associated with cognitive decline and may contribute to memory…
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Artikel Jurnal
Coordinated cellular architecture reveals weakened cortical structure–behavior coupling in normal aging
Normal aging compromises behavioral functions supported by cortical circuits, yet how age-related cellular reorganization relates to weakened circuit-behavior correspondence remains poorly defined. Here, we examined layer 4 (L4) of the mouse primary somatosensory barrel cortex, a thalamorecipient…
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Artikel Jurnal
Selective autophagy inhibition alleviates oxidative stress-associated neurodegeneration in an AD+CCH model
Dysregulated autophagy is increasingly implicated in the progression of Alzheimer's disease (AD), particularly when chronic cerebral hypoperfusion (CCH) coexists and exacerbates neurodegeneration. However, the relationship between autophagy dysregulation and oxidative stress responses under…
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