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Artikel Jurnal
Prediction of cognitive impairment in Parkinson’s disease using TabPFN: an integrative analysis of clinical data, longitudinal trajectories, and lipidomics
BackgroundCognitive impairment is a common and disabling non-motor manifestation of Parkinson’s disease (PD). Early identification of patients at high risk remains challenging, and the metabolic mechanisms underlying cognitive decline are not fully understood.MethodsWe conducted a retrospective…
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Artikel Jurnal
Resting-state cortical alpha frequency in Parkinson’s disease and multiple system atrophy: associations with diagnosis, age, and symptom burden
BackgroundParkinson’s disease (PD) and multiple system atrophy (MSA) are clinically overlapping neurodegenerative disorders that present with a complex, heterogeneous burden of motor and non-motor symptoms. Resting-state EEG reveals that cortical alpha slowing is a hallmark of pathological aging…
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Artikel Jurnal
Electroacupuncture inhibits pyroptosis to improve motor function in an MPTP-induced mouse model of Parkinson’s disease
ObjectivesTo investigate whether electroacupuncture (EA) ameliorates motor dysfunction and protects nigrostriatal dopaminergic neurons in Parkinson’s disease (PD) mice by inhibiting NLRP3 inflammasome-mediated pyroptosis.MethodsMale C57BL/6 mice were randomly assigned before model induction to…
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Artikel Jurnal
Multicomponent training versus elastic-band training for improving global cognition and executive function in older women: a randomized controlled trial
ObjectiveTo compare the effects of multicomponent training (MCT) and elastic-band training (EBT) on global cognition and executive function in older women.MethodsThis single-blind, parallel-group randomized controlled trial was conducted over 16 weeks and included two supervised 60-min sessions per…
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Artikel Jurnal
Carotid atherosclerosis progression in patients with Parkinson’s disease: a prospective cohort study
BackgroundEvidence regarding the association between Parkinson’s disease (PD) and cardio-cerebrovascular risk remains conflicting, and it is unclear whether the dynamic progression of carotid atherosclerosis in PD patients differs from that in non-PD individuals. This study aimed to compare the…
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Artikel Jurnal
Complement C4b and factor B in astrocyte-derived exosomes as novel biomarkers for amnestic mild cognitive impairment
Neuroinflammation represents a fundamental pathological mechanism underlying amnestic mild cognitive impairment (aMCI), with dysregulated activation of the complement system playing a pivotal role. Astrocyte-derived exosomes (ADEs), which are capable of traversing the blood-brain barrier (BBB)…
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Artikel Jurnal
Behavioral markers of motor reserve: stability, lateralization, and consistency
BackgroundMotor reserve has been phenomenologically defined as the capacity to maintain motor performance despite aging-related or disease-related changes, but its objective kinematic basis remains insufficiently characterized. We operationalized motor reserve using measures from a sensor-equipped…
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Artikel Jurnal
Self-reported chewing or swallowing problems and episodic memory performance in older Americans: a longitudinal cohort study
BackgroundImpaired mastication is a plausible modifiable risk factor for dementia, but long-term longitudinal evidence using functional metrics instead of tooth counts is limited. This study investigated the association between self-reported chewing/swallowing problems and cognitive decline…
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Artikel Jurnal
Isogenic human stem cell models reveal mutation-dependent protective mechanisms of APOE3 Christchurch
IntroductionAlzheimer’s disease (AD) is a progressive neurodegenerative disorder influenced by both causal mutations and genetic modifiers. The rare APOE3 Christchurch (APOE3ch) variant has been associated with delayed disease onset in a familial Alzheimer’s disease case, suggesting a potential…
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Artikel Jurnal
Auditory performance and cortical plasticity in blind individuals with sensorineural hearing loss: insights into dual sensory impairment
BackgroundBlind individuals with normal hearing frequently exhibit enhanced auditory abilities driven by compensatory cross-modal neuroplasticity. However, it remains unclear whether these compensatory advantages persist in individuals with dual sensory impairment. This study investigated auditory…
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Artikel Jurnal
Cardiorespiratory fitness is associated with cerebral oxygen extraction in Alzheimer’s disease
Cardiorespiratory fitness (CRF) is a modifiable determinant of brain health and has been associated with greater brain volume, improved cognition, and reduced dementia risk. However, whether CRF influences cerebral oxygen extraction fraction (OEF), a marker reflecting the balance between cerebral…
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Artikel Jurnal
Circulating and cerebrospinal fluid soluble TREM2 levels and risk of perioperative neurocognitive disorders in surgical patients: a systematic review and meta-analysis
BackgroundPerioperative neurocognitive disorders (PND), including postoperative delirium (POD) and cognitive dysfunction (POCD), are common surgical complications in older adults. Neuroinflammation from microglial activation is a key mechanism. Soluble TREM2 (sTREM2) is a blood/CSF biomarker…
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Artikel Jurnal
Effects of transcranial direct current stimulation on gait and balance under dual-task conditions in older adults: a systematic review and meta-analysis
ObjectiveThis systematic review and meta-analysis evaluated the effects of transcranial direct current stimulation (tDCS) on gait and balance outcomes measured under dual-task (DT) conditions in older adults.MethodsFollowing PRISMA guidance, four databases were searched through October 13, 2025…
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Artikel Jurnal
Gut microbial characteristics and kynurenine-related metabolism across sarcopenia groups: associations with neuromuscular and physical function
BackgroundSarcopenia is characterized by heterogeneous alterations in muscle mass, strength, and physical performance and may involve interactions among the gut microbiota, tryptophan metabolism, and neuromuscular function. However, these biological characteristics across different sarcopenia…
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Artikel Jurnal
Effects of 12-week 24-form Tai Chi on cognitive function, cerebral perfusion, and vascular function in postmenopausal women with mild cognitive impairment: an exploratory randomized controlled trial
BackgroundPostmenopausal women are at increased risk of mild cognitive impairment (MCI). Vascular and cerebrovascular dysfunction may contribute to this increased vulnerability. Tai Chi has been shown to benefit cognitive function, but its effects on cerebrovascular health in this high-risk…
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Artikel Jurnal
Differentiating early Parkinson’s disease from multiple system atrophy on multimodal PET/MRI using atlas-guided segmentation and vision transformer classification
IntroductionEarly differentiation between Parkinson’s disease (PD) and multiple system atrophy-parkinsonian type (MSA-P) remains clinically challenging because of overlapping motor symptoms and subtle imaging abnormalities.MethodsWe developed a fully automated multimodal PET/MRI framework for early…
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Artikel Jurnal
Tau protein in Parkinson’s disease: advances in phosphoproteomics and molecular dynamics simulations
Tau dysregulation, particularly abnormal phosphorylation, is increasingly implicated in Parkinson’s disease (PD) and in the pathogenic interaction between Tau and α-synuclein. This review proposes an integrated PD-focused workflow connecting phosphoproteomic discovery, structural modeling…
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Artikel Jurnal
Mediating effect of social frailty on oral frailty and cognitive function in older adults: a cross-sectional study in a rural Chinese community
BackgroundCognitive function has been associated with both social and oral frailty. However, few studies have explored how social frailty and oral frailty jointly relate to cognitive function. This study aimed to explore whether social frailty plays a mediating role in the association between oral…
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Artikel Jurnal
Application of unsupervised and supervised machine learning approaches to blood-based biomarkers of Alzheimer’s disease in a memory clinic cohort
IntroductionBlood-based biomarkers (BBMs) are promising tools to facilitate biological diagnosis of Alzheimer’s Disease (AD). Establishing reliable cutoffs for BBMs represents a major issue for real-world implementation and the investigation of combined BBM approaches is limited. Our aim is to test…
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Artikel Jurnal
Dysfunction of lipid metabolism and lysosomal capacity: at the core of microglial aging?
As primary immune cells of the central nervous system (CNS), microglia maintain immune surveillance, inflammation regulation, cell interactions and debris clearance. These dynamic and adaptive effector functions are reciprocally sustained by microglial metabolism. Lipids are emerging as a key…
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