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Frontiers in Aging Neuroscience
Scopus
ISSN 1663-4365 · Frontiers Media S.A. · 8.223 artikel di indeks
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Artikel Jurnal
The interplay of homeostasis, inflammation, and oxidative stress in neurodegenerative disorders: the role of biological markers, antioxidants, lithium, and TMS — a proposed framework for preventing neurodegenerative disorders through biomarkers and multimodal therapies
Neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) are among the most significant health challenges of aging, characterized by progressive cognitive and motor decline. Increasing evidence suggests that these conditions are not inevitable outcomes of aging but…
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Dynamic trends, spatial clustering, and multi-model projections of the global burden of Alzheimer’s disease and other dementias: an analysis of GBD 1990–2021 data to 2050
BackgroundAlzheimer’s disease and other dementias (ADOD) are a leading causes of disability and mortality among older adults worldwide. While the rising burden is recognized, comprehensive analyses of its dynamic growth rates, spatial clustering patterns, and comparative long-term forecasts remain…
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From knowledge landscapes to network mechanisms: charting regulated cell death pathways in ALS
ObjectiveTo map the research landscape linking amyotrophic lateral sclerosis (ALS) with regulated cell death (RCD) and to integrate bibliometric trends with bioinformatics evidence to identify convergent mechanisms and actionable targets.MethodsWeb of Science Core Collection, PubMed, and Scopus…
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Artikel Jurnal
The effect of hearing ability on dual-task performance following multi-domain training in older adults with mild cognitive impairment: findings from the SYNERGIC trial
BackgroundHearing loss is one of the largest potentially modifiable risk factors for dementia and is linked with poor cognitive-motor dual-task performance (e.g., walking while performing a cognitive task). Hearing loss is more prevalent and severe in males, whereas dementia is more prevalent in…
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Artikel Jurnal
Trends and cross-country inequalities in the global burden of Alzheimer’s disease and other dementias among adults aged 65+ years, 1990–2021: a population based study with projections into 2050
BackgroundAlzheimer’s disease and other dementias (ADOD) pose a significant global health challenge, with projected annual increases. The growing elderly population exacerbates burdens, underscoring the need for interventions.MethodsUsing data from the Global Burden of Disease Study 2021, we…
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Artikel Jurnal
Gut-kidney-brain axis and daytime sleepiness in Parkinson's disease and chronic kidney disease: an expert narrative review
BackgroundExcessive daytime sleepiness (EDS) is a debilitating comorbidity in over 80% of patients with Parkinson's disease (PD) and chronic kidney disease (CKD). Evidence implicates dysregulation of the gut-kidney-brain axis as a may contribute of EDS pathogenesis, though detailed mechanistic…
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The temporal and stimuli-specific effects of LPS and IFNγ on microglial activation
Microglia, the resident immune cells of the central nervous system (CNS), play a pivotal role in health and disease maintaining homeostasis and mediating neuroinflammatory responses. Their activation is a dynamic and context-dependent process characterized by diverse phenotypic states defined by…
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Which aspects of the everyday behavior of older dogs correlate with performance on a visuo-spatial memory test and the canine cognitive dysfunction rating scale (CCDR)?
The behavioral aspects of aging in the domestic dog have primarily been investigated through owner-reported scales that measure specific behavioral signs of aging, and laboratory-based memory and cognitive tests. We need to know more about how aging affects everyday behavior and functionality in…
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Changes in the brain [NAD+]/[NADH] and [NADPH]/[NADP+] with aging and anti-aging dietary restriction
Changes in brain [NADPH]/[NADP+] and [NAD+]/[NADH] may contribute to aging. Anti-aging dietary restriction (DR) and intermittent fasting (IF) alter redox states that may contribute to their longevity effects. Pyruvate/lactate and acetoacetate/beta-hydroxybutyrate are indicators of the cytoplasmic…
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Artikel Jurnal
Forecasting individualized progression of Alzheimer’s disease using structural MRI and population spatiotemporal priors
ObjectiveAlzheimer’s disease (AD), the most common neurodegenerative disorder, involves the progressive loss of vulnerable neurons. Tracking its progression via structural magnetic resonance imaging (sMRI), which captures subtle brain anatomical changes, is vital for advancing diagnosis and…
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Artikel Jurnal
Transcutaneous auricular vagus nerve stimulation may improve cognitive deficits in neuropsychiatric diseases—a systematic review
BackgroundTranscutaneous auricular vagus nerve stimulation (taVNS) is a safe, effective, and non-invasive therapeutic approach for various neuropsychiatric disorders, including depression, headache disorders, and epilepsy. Cognitive impairment is a common and clinically relevant feature across…
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Artikel Jurnal
Understanding illness awareness in Alzheimer’s disease: a qualitative study with patient–caregiver dyads in Colombia
BackgroundDiminished awareness of illness is a frequent neuropsychiatric symptom in people with Alzheimer’s disease. It has been linked to emotional and behavioral challenges such as depression, apathy, irritability, and poor adaptation to loss of function. Despite its clinical importance, little…
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Spinal glial cell derived extra-pituitary prolactin contributes to postoperative pain in females
Peripheral and spinal prolactin (PRL) receptor (PRLR) signaling contributes to the female-selective regulation of pain. This study investigated the relative roles of pituitary-derived PRL (PRLpit) and extra-pituitary PRL (PRLext) in these effects. Using STAT5 phosphorylation (pSTAT5) as a surrogate…
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Correction: Choline alphoscerate: insights between acquired certainties and future perspectives
Graphical AbstractDiagram illustrating the effects of choline alphoscerate on the brain. It highlights benefits like enhancement of cognitive functions and synaptic signaling. Key aspects include epigenetic regulation, acetylcholine neurotransmission, and membrane lipid composition. The diagram…
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Spontaneous tauopathy with parkinsonism in an aged cynomolgus macaque
IntroductionAged non-human primates have been reported to develop tau pathology; however, most studies lack evidence of any associated neurological symptoms. To determine whether spontaneous tauopathy in cynomolgus macaques manifests with neurological symptoms, we evaluated a symptomatic aged…
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An integrated CSF-serum biomarker model for predicting clinical progression in Alzheimer’s disease
BackgroundThe early and accurate identification of Alzheimer’s disease (AD) remains a significant clinical challenge. Integrating novel peripheral blood-based biomarkers with established cerebrospinal fluid (CSF) measures may offer a promising strategy to enhance diagnostic accuracy and risk…
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Dual roles of lactate and lactylation modification in the nervous system: neuroprotection and neuroinjury
Lactate is the terminal product of anaerobic oxidation within the glucose metabolism pathway. Traditionally, lactate has been regarded as a metabolically insignificant byproduct derived from incomplete oxidation. However, recent evidence suggests that lactate plays dual roles in the nervous system…
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Physical exercise mitigates motor and muscular deficits in the 3xTg-AD model of Alzheimer’s disease
IntroductionAlzheimer’s disease (AD) is the most common neurodegenerative disease worldwide, characterized by progressive cognitive decline and, in advanced stages, marked motor impairments. These motor deficits are associated with muscle atrophy, mitochondrial dysfunction, and amyloid-β (Aβ)…
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Artikel Jurnal
Feasibility randomized controlled trial of a home-based support program for family caregivers of people with Alzheimer’s disease
ObjectiveThis study aimed to develop and preliminarily evaluate the feasibility of a home-based care program for family caregivers of individuals with Alzheimer’s disease (AD).MethodsWe developed a home-based intervention for AD caregivers through systematic literature review and two-round Delphi…
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