31,912 results
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Journal Article
Another prospective study on the safety of ondansetron for nausea and vomiting of pregnancy: addressing ongoing concerns
BackgroundThe safety of ondansetron for nausea and vomiting in pregnancy (NVP) remains a subject of ongoing debate, driven by conflicting study results and a disagreement between the European Medicines Agency (EMA) and the European Network of Teratology Information Services (ENTIS) regarding its…
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Journal Article
Effectiveness and safety of cemiplimab in locally advanced and metastatic cutaneous squamous cell carcinoma
Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer with increasing incidence. The anti-PD-1 therapy cemiplimab has shown its antitumor activity in locally advanced (lacSCC) and metastatic cSCC (mcSCC). This retrospective study assessed the real-life effectiveness and safety of…
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Journal Article
Predictive value of ALBI score and age for developing resistance to trastuzumab in HER-2-positive breast cancer patients: prediction based on a real-world case series from a single center in China
ObjectiveTo assess the clinical value of the ALBI score and age in predicting trastuzumab resistance in patients with HER-2 positive breast cancer (BC).MethodsA retrospective cohort study was conducted on patients with HER-2 positive BC treated with trastuzumab at the Department of Thyroid and…
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Journal Article
Shikonin inhibits MRSA biofilm formation to alleviate periprosthetic joint infection
ObjectiveTo alleviate periprosthetic joint infection (PJI) with methicillin-resistant Staphylococcus aureus (MRSA), shikonin (SKN) had been used to intervene the biofilm formation of MRSA in vivo and in vitro, which provides theoretical support and practical foundation for SKN as a novel drug…
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Journal Article
Bridging the translational gap in systems neuroscience: from circuit mechanisms to clinical therapeutics
The advent of optogenetics, chemogenetics, and high-density neural recording technologies has propelled systems neuroscience into a golden age, generating unprecedented mechanistic insights into how defined neural circuits orchestrate behaviour. These tools have allowed us to move beyond…
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Journal Article
Cyclovirobuxine D suppresses cancer stemness in osteosarcoma with implication of the noncanonical NF-kappaB pathway
BackgroundCyclovirobuxine D (CVB-D), an alkaloid from Buxus microphylla, exhibits anticancer effects in various tumors, but its role in osteosarcoma remains unexplored. This study investigates its efficacy and mechanism in osteosarcoma.MethodsWe screened a drug library and evaluated CVB-D’s effects…
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Journal Article
Low-dose naltrexone as an adjunctive treatment for major depressive disorder: findings from a randomized, double-blind, placebo-controlled hybrid parallel-arm study
IntroductionMajor depressive disorder (MDD) is a leading cause of global disability. Current treatments are limited by poor efficacy in approximately one-third of patients. Neuroinflammation may be an underlying mechanism of MDD and represents a novel target for pharmacological therapy. This study…
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Journal Article
Ethnopharmacology, phytochemistry, and pharmacology of sea buckthorn (Hippophae rhamnoides L.): a comprehensive review
This review provides a comprehensive synthesis of the ethnopharmacological uses, modern applications, phytochemistry, and pharmacological mechanisms of Hippophae rhamnoides L. (H. rhamnoides) It begins by detailing its foundational role in traditional medical systems within its native range…
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Journal Article
Sex-related pharmacokinetic and pharmacological responses to 4F-furanylfentanyl
BackgroundNovel synthetic opioids (NSOs), including a variety of fentanyl analogs (FAs) and emerging non-fentanyl compounds, have increasingly been implicated in overdose fatalities worldwide. Among these, 4-fluoro-furanylfentanyl (4F-FUF) is a potent FA with limited in vivo pharmacotoxicological…
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Journal Article
A network pharmacology–guided multi-omics and spatial single-cell framework nominates WT1 as a spironolactone-linked immune biomarker in prostate cancer
IntroductionSpironolactone (SPI), a mineralocorticoid receptor antagonist with anti-androgenic activity, has emerged as a candidate for drug repurposing in prostate cancer (PCa). However, the cellular pharmacology governing its impact on the tumor microenvironment and specific molecular targets…
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Journal Article
Fixed-dose combination antihypertensive therapy and healthcare utilization in U.S. adults with hypertension: a propensity score–based analysis of a nationally representative population
BackgroundFixed-dose combination (FDC) antihypertensive therapy is recommended by contemporary guidelines to improve adherence and blood pressure control. However, real-world evidence evaluating its impact on healthcare utilization, compared with the multi-pill combination (MPC) therapy in…
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Journal Article
Analysis of the clinical characteristics of direct oral anticoagulants-associated atraumatic splenic rupture
ObjectiveAtraumatic splenic rupture (ASR), though rare, is an adverse event linked to direct oral anticoagulants (DOACs). Given their widespread use and potentially fatal consequences if undiagnosed, heightened clinical awareness of DOAC-associated ASR is crucial. Our aim was to analyze the…
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Journal Article
Exploratory pharmacokinetic-pharmacodynamic characterization and safety of standardized Andrographis paniculata aqueous extract capsules in patients with mild COVID-19
IntroductionAndrographis paniculata has been used in the management of COVID-19-related conditions during the SARS-CoV-2 pandemic. However, human pharmacokinetic-pharmacodynamic (PK/PD) evidence to support a rationale for safe and evidence-based dosing of standardized extracts in clinical use…
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Journal Article
Evaluation of the concordance of asthma remission definitions according to international guidelines in a cohort of patients treated with monoclonal antibodies for severe asthma
BackgroundThe availability of biological therapies has helped achieve clinical remission (CR) in patients with severe asthma (SA). Scientific societies issued different definitions of remission, with the common denominator of the suspension of systemic corticosteroids for at least 1 year…
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Journal Article
Thymoquinone combined with conventional antibiotics against pandrug-resistant Staphylococcus aureus: a pharmacodynamic and molecular simulation strategy to overcome bioavailability limitations
BackgroundInfections with pandrug-resistant (PDR) Staphylococcus aureus (S. aureus) present no available treatment alternatives, even when employing most antibacterial combination regimen. Restoring the effectiveness of existing antibiotics especially through the integration of safe plant-derived…
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Journal Article
Gabapentin CNS exposure and analgesic response are modulated by OCT2 genotype in patients with chronic neuropathic pain
IntroductionGabapentin (GBP) is commonly used for chronic neuropathic pain, yet its therapeutic response varies widely across individuals. As a substrate of the organic cation transporter 2 (OCT2), encoded by the SLC22A2 gene, GBP’s penetration into the central nervous system (CNS) may be…
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Journal Article
PoMA-10: a dual-action antiviral disrupting SARS-CoV-2 Spike–ACE2 interaction and protecting lung tissue
This study aimed to identify small molecules that inhibit the binding of the SARS-CoV-2 Spike protein to its host receptor, angiotensin-converting enzyme 2 (ACE2), without impairing the enzymatic activity of ACE2. Such inhibitors may support the development of broad-spectrum antivirals and…
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Journal Article
Pharmacological strategies to minimize or avoid neuromuscular blocking agents during general anesthesia: a comprehensive approach from airway management to surgical requirements
Neuromuscular blocking agents (NMBAs) are commonly used in general anesthesia and are widely applied in airway management and surgical requirements. However, the traditional use of NMBAs in anesthetic strategies has exposed potential issues, particularly residual neuromuscular blockade, which is…
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Journal Article
Baicalin chemosensitivity enhancement of cisplatin in bladder cancer via autophagy flux inhibition
BackgroundCisplatin-based chemotherapy remains the standard treatment for advanced bladder cancer (BC); however, nephrotoxicity and chemoresistance limit its clinical application. Baicalin, a flavonoid metabolite derived from the botanical drug, Scutellaria baicalensis Georgi, has been reported to…
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