31.912 hasil
Menampilkan 201–220 · 0,40 detik · RSS
-
Artikel Jurnal
Multi-omics analysis reveals the mechanism of Huaganjian in alleviating cholestatic liver fibrosis
Huaganjian (HGJ) is a traditional Chinese medicinal formula with liver-protective effects. However, the pharmacological mechanisms of the effects of HGJ on cholestatic liver fibrosis (CLF) are yet to be clarified. To evaluate the effects of HGJ on CLF and elucidate the underlying mechanisms…
-
Artikel Jurnal
Compensatory attenuation of cortical apoptosis by SK2 downregulation following ketamine anesthesia
IntroductionA single exposure to general anesthetic can induce acute increase in neuronal apoptosis of the neonatal brain; however, how the brain counteracts the anesthetic-induced neurotoxicity remains unknown. The aim of this study is to explore how the neonatal cerebral cortex responds to…
-
Artikel Jurnal
Effectiveness and safety of Chinese traditional medicine Ulcer Ointment for skin ulcers: a systematic review and meta-analysis of randomized controlled trials
IntroductionUlcer Ointment (UO), a topical agent derived from traditional Chinese medicine, has been widely used for skin ulcers. This review evaluates its effectiveness and safety.MethodsWe systematically searched eight databases for randomized controlled trials (RCTs) focusing on UO for skin…
-
Artikel Jurnal
Exploring Colombian medicinal flora used in indigenous and campesino health systems for neuropsychiatric disorders and neuropharmacological potential: an ethnopharmacological review
Neuropsychiatric disorders affect nearly one billion people worldwide, yet many existing psychopharmacological treatments are limited by adverse effects, drug interactions, and variable efficacy. Ethnopharmacological knowledge embedded in Indigenous health systems offers important perspectives for…
-
Artikel Jurnal
Gut microbiota and spleen-strengthening and dampness-dispelling therapies in obesity and related metabolic disorders: key mechanisms and therapeutic potential
Obesity, characterized by excessive body fat and systemic low-level inflammation, is closely linked to energy imbalance and gut dysbiosis. Traditional Chinese medicine (TCM) attributes obesity to spleen deficiency and dampness excess, advocating “strengthening the spleen and expelling dampness” as…
-
Artikel Jurnal
A review on the genus Kadsura: ethnobotany, pharmacology, and molecular pharmacognosy
Kadsura Kaempf. ex Juss., belonging to the Schisandraceae family, is a key ethnomedicinal resource in traditional Asian medicine, valued for both dietary and therapeutic roles. Traditionally used to boost blood circulation, relieve pain, and dispel wind-cold-damp pathogens, its metabolites have…
-
Artikel Jurnal
GuiLingJi ameliorates mild cognitive impairment by targeting unsaturated fatty acid metabolism to inhibit GPR120/NF-κB mediated neuroinflammation
BackgroundMild cognitive impairment (MCI) is an intermediate condition between normal aging and dementia. Drug intervention is an important way to prevent MCI from developing into dementia. GuiLingJi (GLJ) is a traditional Chinese medicine formulae and it has the effect of enhancing memory. In view…
-
Artikel Jurnal
Benefit-risk assessment of the use of toxic botanical drugs in superiority field: a case study on Aconitum carmichaeli Debx
ObjectiveThe study aimed to establish a benefit-risk assessment (BRA) model utilizing multi-criteria decision analysis (MCDA), in order to evaluate the benefit-risk relationship of decoctions containing Aconitum carmichaeli Debx. (Fuzi) in the treatment of rheumatoid arthritis (RA), laying the…
-
Artikel Jurnal
Efficacy and safety of tyrosine kinase inhibitors in advanced hepatocellular carcinoma patients with Child-Pugh A and B cirrhosis: a meta-analysis
BackgroundHepatocellular carcinoma (HCC) remains a leading cause of cancer mortality. Tyrosine kinase inhibitors (TKIs) are widely used in advanced HCC, yet outcomes may differ by hepatic reserve. We compared the efficacy and safety of guideline-recommended TKIs between patients with Child–Pugh A…
-
Artikel Jurnal
Efficacy of pancreatic enzyme replacement therapy (PERT) in the treatment of gastrointestinal symptoms after gastric cancer surgery: study protocol for a multicenter randomized controlled open-label trial
IntroductionPancreatic exocrine insufficiency (PEI), presenting as bloating or diarrhea, affects 26%–100% of patients after gastrectomy, delaying recovery and impairing quality of life. Pancreatic enzyme replacement therapy (PERT) is the standard PEI management, yet its efficacy after gastric…
-
Artikel Jurnal
Inhibition of CDK9 alleviates osteoarthritis by suppressing inflammation and reducing chondrocyte apoptosis
BackgroundPosttraumatic osteoarthritis (PTOA) develops following joint trauma and leads to pain and functional impairment. This study aimed to investigate the role and mechanism of cyclin-dependent kinase 9 (CDK9) in PTOA progression.MethodsWe established an in vitro PTOA model by treating primary…
-
Artikel Jurnal
Antidepressant-like effects of Rg1 by mycn: promotion of neurogenesis in the hippocampus
Ginsenoside Rg1 has been shown to have antidepressant effects by increasing hippocampal neurogenesis, but the molecular mechanisms remain unclear. In this research, we showed that Rg1 has antidepressant-like effects by increasing neurogenesis in the hippocampus, and these effects are achieved…
-
Artikel Jurnal
Development of an LC-MS/MS method for amantadine detection in human plasma using ZIF-8 as adsorbent and pharmacokinetic investigation
In this study, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantitative determination of amantadine in human plasma, with the incorporation of an internal standard to improve analytical accuracy. Plasma samples collected from volunteers…
-
Artikel Jurnal
Peptide-based antimicrobial effect against carbapenem-resistant Acinetobacter baumannii: preclinical drug assessment and translational potential
BackgroundCarbapenem-resistant Acinetobacter baumannii (CRAB) has become a major global public health threat, with limited treatment options and poor clinical outcomes. In this study, we evaluated the potential of antimicrobial peptides as adjuvants in the treatment of CRAB.MethodsIn vitro…
Menampilkan maksimal 50 halaman. Persempit pencarian dengan filter untuk hasil yang lebih spesifik.