31,912 results
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Journal Article
Estimating real-world treatment effects in the presence of measurement error and sparse outcome data using propensity score methods
IntroductionThe real-world treatment effect of a novel treatment can be estimated by analysing routinely collected patient data, in the form of Electronic Health Records (EHR). Any treatment allocation in EHR is not randomised and there may be systematic differences between the treatment groups…
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Journal Article
Epigenetic and mitoepigenetic regulation in cancer and therapeutic perspectives
Epigenetic modifications on nuclear and mitochondrial DNA constitute key regulatory layers influencing the transcriptional, metabolic, and phenotypic adaptability of cancer cells. The canonical principles of epigenetic control encompass DNA methylation, histone modification, and non-coding…
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Journal Article
IR-780 improves urination function and complications in rats with partial bladder outlet obstruction by protecting bladder smooth muscle cell mitochondria from oxidative stress
IntroductionPartial bladder outlet obstruction (pBOO) is the most common cause of lower urinary tract symptoms (LUTS). Prolonged BOO induces bladder remodeling, which can lead to severe bladder dysfunction and refractory LUTS in some patients, even after obstruction resolution. This condition…
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Journal Article
Nanotechnology-enabled delivery of luteolin: a comprehensive review on multidisease therapeutic applications
Luteolin is a natural flavonoid compound widely found in various plants, known for its antioxidant, anti-inflammatory, cardiovascular protective and anti-tumor activities. However, its low bioavailability due to rapid metabolism and low solubility hinders its clinical application. In recent years…
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Journal Article
Prediction of site-specific drug deposition via dry powder inhaler using non-invasive real-time particle emission signal monitoring system
BackgroundAccurate evaluation of regional drug deposition within the respiratory tract is essential for optimizing inhalation therapy efficacy and minimizing adverse effects. However, non-invasive, real-time quantitative methods for site-specific drug delivery assessment remain limited.ObjectiveTo…
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Journal Article
Dasatinib and quercetin mitigate radiation-induced lung injury by eliminating senescent cells in a rat model
BackgroundRadiation-induced lung injury (RILI) is a major dose-limiting toxicity in thoracic radiotherapy, and accumulating evidence implicates radiation-induced cellular senescence in its pathogenesis. This study aimed to investigate whether combination therapy with dasatinib and quercetin (DQ)…
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Journal Article
Acute post-infusion hypokalemia following rituximab therapy in patients with nephrotic syndrome: case series and literature review
BackgroundRituximab has become an important therapeutic option for nephrotic syndrome (NS), and its adverse event profile is generally well characterized. However, reports of acute hypokalemia specifically occurring in the post-infusion period remain rare. We aimed to present and analyze cases of…
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Journal Article
The impact of nutritional, environmental, and lifestyle factors on neurological disorders: therapeutic implications and mechanistic insights
Neurological disorders like Alzheimer’s, Parkinson’s, multiple sclerosis, and primary psychiatric conditions are complex, arising from a mix of genetic and modifiable risks. Growing evidence indicates that nutrition, environment, and lifestyle significantly influence disease development…
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Journal Article
Recent developments in quercetin nanomedicine and applications in osteoarthritis and rheumatoid arthritis therapies
Quercetin has attracted increasing attention in the research of treatments for rheumatoid arthritis and osteoarthritis due to its excellent anti-inflammatory, antioxidant, and joint-protective effects. However, the bioavailability of quercetin is relatively low, primarily due to its poor…
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Journal Article
Novel roles of SETD2 in tumor metabolism and immunotherapy: a systematic review and meta-analysis
BackgroundSET domain-containing 2 (SETD2), the sole histone H3 lysine 36 trimethyltransferase, has emerged as a critical tumor suppressor across multiple cancer types. Recent evidence suggests SETD2 orchestrates complex interactions between metabolic reprogramming and immune evasion in the tumor…
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Journal Article
Machine learning-assisted analysis of serum metabolomics for identifying biomarkers in intrinsic and idiosyncratic drug-induced liver injury
ObjectiveThis project aims to employ high-performance chemical isotope labeling (HP-CIL) liquid chromatography–mass spectrometry (LC-MS) to conduct a metabolomic study on the mechanisms underlying intrinsic and idiosyncratic drug-induced liver injury (DILI). By comparing the metabolic…
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Journal Article
Evaluating a multifaceted stewardship intervention on proton pump inhibitor utilization: an interrupted time-series analysis of prescribing patterns in a northwest Chinese hospital
BackgroundPromoting the rational use of proton pump inhibitors (PPIs) has become an important aspect in controlling the growth of pharmaceutical expenditures in China. In recent years, the first national guidelines for the clinical application of PPIs and the second batch of the China National Key…
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Journal Article
Clopidogrel-induced drug-induced hypersensitivity syndrome following percutaneous coronary intervention: a case report of therapeutic dilemma and management strategy
BackgroundDrug-induced hypersensitivity syndrome (DIHS), also known as drug reaction with eosinophilia and systemic symptoms (DRESS), is a rare but potentially life-threatening adverse drug reaction. Clopidogrel induced DHS following percutaneous coronary intervention (PCI) presents a unique…
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Journal Article
Sevelamer inhibits the formation of cholesterol gallstones by modulating bile acid metabolism
BackgroundThe purpose of this study was to investigate the effect and mechanism of Sevelamer hydrochloride (Sev) on cholesterol gallstone formation via the intestinal Fxr-Fgf15 signaling pathway in a mouse model.MethodsA cholesterol gallstone mouse model was established. Mice were divided into…
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Journal Article
A comparative study on the efficacy and safety of biosimilar (Rimmyrah) and reference ranibizumab in patients with diabetic macular edema
ObjectiveThis study evaluated the efficacy and safety of the biosimilar Rimmyrah versus the reference ranibizumab in patients with diabetic macular edema (DME).MethodsThis retrospective study included 70 patients with DME. They were divided into two groups: 35 patients (35 eyes) received the…
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Journal Article
Efficacy and safety of Salvia miltiorrhiza and ligustrazine injection for heart failure: a systematic review and meta-analysis
ObjectiveTo systematically evaluate the efficacy and safety of SMLI in patients with HF.Materials and methodsEight electronic databases were systematically searched from inception up to July 2025 to identify randomized controlled trials (RCTs) comparing SMLI combined with conventional treatment…
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Journal Article
Safety of individualized herbal medicine for dysmenorrhea: pharmacovigilance from South Korea’s national pilot
BackgroundIn 2020, South Korea’s National Health Insurance (NHI) began reimbursing individually prescribed herbal medicine decoctions (HMDs) for dysmenorrhea, highlighting the need for robust post-coverage safety monitoring using national claims data.ObjectiveTo evaluate the safety of reimbursed…
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Journal Article
Incorporating patient-reported outcome measures into routine paediatric pharmacovigilance: opportunities for safety monitoring with practical use scenarios from paediatric oncology
BackgroundTraditional pharmacovigilance systems often fail to capture children’s experiences of adverse events (AEs), particularly subjective symptoms that affect daily functioning and quality of life. Patient-Reported Outcome Measures (PROMs) offer a complementary perspective by enabling direct…
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