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Artikel Jurnal
Minnelide ameliorates Col4a5+/− mice by upregulating Col4a5 and alleviating endoplasmic reticulum stress
BackgroundAlport syndrome (AS) is a progressive hereditary nephropathy caused by mutations in collagen IV genes, notably COL4A5, leading to proteinuria and kidney failure. Current therapies using RAAS inhibitors show limited efficacy. Triptolide, the main active component of Tripterygium wilfordii…
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Artikel Jurnal
Predictive modelling of the dynamics of antimicrobial resistance: creation of a bank of renewable models based on machine learning
IntroductionThe growth in antimicrobial resistance (AMR) presents a global threat, caused to a large extent by irrational antimicrobial consumption. For its part, mathematical modelling of the dynamics of AMR on the basis of data on antimicrobial consumption and historical levels of resistance may…
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Artikel Jurnal
Immunosuppressant treatment reduces cocaine-induced behavioral sensitization in mice
BackgroundNeuroinflammation plays fundamental, though still not fully understood, roles in the pathophysiology of substance use disorders, including cocaine addiction. Chronic cocaine exposure promotes neuroinflammatory signaling and synaptic alterations in brain regions involved in reward and…
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Artikel Jurnal
Unraveling the role of 3-mercaptopyruvate sulfurtransferase-derived hydrogen sulfide in triple-negative breast cancer chemoresistance
BackgroundTriple-negative breast cancer (TNBC) frequently develops resistance to chemotherapy. Cancer-supporting roles of the endogenous gaseous mediator hydrogen sulfide (H2S) have been identified. We investigated whether endogenous H2S, produced by 3-mercaptopyruvate sulfurtransferase (3-MST)…
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Artikel Jurnal
Drug resistance mechanisms in Mycobacterium tuberculosis infection and challenges in vaccine development
Drug-resistant Mycobacterium tuberculosis(Mtb) has become a global public health crisis, and its diverse drug resistance jointly reduces the effectiveness of antibacterial drugs. Mtb resistance is not merely genetic but involves a synergistic interplay of cell wall remodeling, metabolic…
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Artikel Jurnal
Crocin protects against smoke-induced chronic obstructive pulmonary disease by regulating AKT1
BackgroundChronic obstructive pulmonary disease (COPD) is an inflammatory airway disorder characterized by persistent airflow limitation and pathological features such as airway remodeling. Identifying molecular targets involved in airway epithelial dysfunction is crucial for developing COPD…
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Artikel Jurnal
Characterization and anti-inflammatory studies of supramolecular assemblies of chlorogenic acids with metal ions
IntroductionSelf-assembled natural small molecules are believed to have numerous potential applications, particularly in the material and pharmaceutical industries, as self-assembly increases the anti-inflammatory, antitumor, antiviral, and other biological activities. In this study, we synthesized…
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Artikel Jurnal
Targeted lipidomics meets transcriptomics: how cinobufagin rewires fatty acid, sphingolipid, and glycerophospholipid metabolism to combat hepatoma cell growth
IntroductionHepatocellular carcinoma (HCC) is a common malignant tumor, is characterized by an early stage that is not easy to diagnose and a high mortality rate in the late stage, which is a serious threat to patients' lives. Abnormalities in lipid metabolism are closely related to the development…
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Artikel Jurnal
Pharmacogenomics of risperidone in autism spectrum disorder: a minireview
Risperidone is one of the most widely prescribed antipsychotics for the management of irritability and associated behavioral symptoms in autism spectrum disorder (ASD), yet clinical response and adverse-effect risk vary widely among individuals. Pharmacogenomic (PGx) research has sought to explain…
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Artikel Jurnal
Early metoprolol use in ICU patients with congestive heart failure is associated with increased 30-day mortality: a causal machine learning study
BackgroundThe risk-benefit balance of early metoprolol administration in critically ill patients with congestive heart failure (CHF) admitted to the intensive care unit (ICU) remains controversial. However, high-quality causality clinical evidence is still lacking. This study utilized real-world…
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Artikel Jurnal
1-Nitropyrene induces acute lung injury via SYVN1/Caspase-11-mediated apoptosis and pyroptosis in pulmonary epithelial cells
Background1-Nitropyrene (1-NP) is harmful to the respiratory system and can evoke acute lung injury (ALI). Pyroptosis and apoptosis, two important types of programmed cell death, are involved in the pathological process of ALI. However, the roles and mechanisms of pyroptosis and apoptosis on…
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Artikel Jurnal
Piezo1 as a mechanical checkpoint in T cell immunotherapy for solid tumors
T cell-based immunotherapies exhibit limited efficacy against solid tumors, a challenge primarily attributed to the immunosuppressive and mechanically hostile tumor microenvironment (TME). Within this context, the mechanosensitive ion channel Piezo1 has emerged as a key TME mechanosensor, yet its…
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Artikel Jurnal
Progress, critical challenges, and translational prospects of intranasal administration of botanical essential oils for the treatment of depression
Depression is a highly prevalent and disabling psychiatric disorder worldwide. However, currently available first-line antidepressant therapies are frequently limited by delayed onset of action, a high incidence of adverse effects, and inconsistent therapeutic efficacy, underscoring the urgent need…
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Artikel Jurnal
Tumour microenvironment and HER2-low status dictate response and resistance to anthracycline-taxane chemotherapy in premenopausal TNBC: a retrospective multicohort study
BackgroundPremenopausal women with triple-negative breast cancer (TNBC) exhibit considerable heterogeneity in their response to standard anthracycline and taxane-based chemotherapy, yet the underlying mechanisms remain poorly understood. We aimed to investigate the combined role of the tumour…
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Artikel Jurnal
Isoniazid subverting erythrocyte homeostasis: implications for tuberculosis therapy
Isoniazid (INH) is a frontline anti-tuberculosis drug. Understanding the molecular mechanisms by which INH affects antioxidant defence in human blood cells, particularly erythrocytes vulnerable to oxidative damage, remains essential to improving therapy safety. Here, the transcriptomic data of…
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Artikel Jurnal
Global Panoramic analysis of clinical research in cell therapy: clinical trial landscape, marketed products, and regulatory trends
IntroductionCell therapy is a vital field in modern medicine. This review assesses its global clinical development landscape, approved products, and regional regulatory characteristics.MethodsA comprehensive search and analysis of global clinical trial databases (e.g…
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Artikel Jurnal
Impact of non-steroidal anti-inflammatory drugs on malignant transformation in oral lichen planus: insights from a real-world cohort study
IntroductionOral lichen planus (OLP) is a chronic inflammatory condition with malignant potential for oral squamous cell carcinoma (OSCC). Differential risks of pharmacological treatments, particularly long-term use, remain unclear. We aimed to quantify OSCC risk across treatment modalities and…
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Artikel Jurnal
Metabolomic analysis of plasma and brain tissues in fentanyl-induced conditioned place preference mice
Fentanyl abuse has been associated with neurological and psychological harm. However, the metabolic changes within the peripheral circulation and central nervous system involved in fentanyl addiction have not been well explored. In the present study, metabolic changes in plasma, caudate putamen…
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Artikel Jurnal
Sphingosine-1-phosphate receptor signaling regulates an ERK1/2–p65 molecular switch in macrophages during Leishmania donovani infection
Leishmania donovani establishes intracellular infection by suppressing macrophage inflammatory responses. Although sphingosine-1-phosphate (S1P) signaling is known to regulate macrophage function, the receptor isotype–specific mechanisms involved during Leishmania donovani infection remain unclear…
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Artikel Jurnal
Alternative methods for pharmacological research on the action mechanisms of natural products used in the treatment of type 2 diabetes: a systematic review
Type 2 diabetes (T2D) is a complex metabolic disorder characterized by alterations in multiple pathways of carbohydrate and lipid metabolism. Due to the involvement of a network of dysfunctional enzymes contributing to hyperglycemia, ethnopharmacological research has increasingly focused on…
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