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Artikel Jurnal
Historical studies on the use of Rhubarb in Japan
BackgroundRhubarb product is the crude drug derived from the root or rhizome of Rheum or other related plants, and has been used since ancient times in Asian and European countries. However, the original plant species for Rhubarb product had been confused throughout its long history and across…
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Artikel Jurnal
Licochalcone B suppresses oxidative stress and apoptosis accompanied by upregulating Nrf2/HO-1 pathway to ameliorate diabetic nephropathy in mice
IntroductionDiabetic nephropathy (DN), as a complication of diabetes, is one of the major causes of end-stage renal disease. Licochalcone B (LCB), a flavonoid active component derived from licorice, is well known for its anti-inflammatory and antioxidant properties. However, the influence of LCB on…
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Artikel Jurnal
Cellular strategies for repairing trapped protein-DNA complexes
DNA-protein crosslinks (DPCs) are highly toxic DNA lesions that arise both from normal cellular metabolism and as an intended consequence of cancer chemotherapy. Key anticancer agents, including topoisomerase poisons and PARP inhibitors, exert their therapeutic effects by trapping enzymes on DNA…
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How do nanoparticle properties shape pharmacokinetics and pharmacodynamics? A mechanistic review
Many therapeutics fail due to suboptimal pharmacokinetics/pharmacodynamics (PK/PD), and the development of nanomedicine remains partly empirical. We present a protocol-guided, mechanistic review that links nanoparticle (NP) physicochemical traits (such as size, surface charge/hydrophobicity…
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Artikel Jurnal
Reassessing cancer risk with GLP-1 receptor agonists: a comprehensive meta-analysis of gastrointestinal malignancies
Background and ObjectivesGlucagon-like peptide-1 receptor agonists (GLP-1 RAs) are widely prescribed for type 2 diabetes mellitus (T2DM) and obesity. While their metabolic benefits are established, concerns persist about a possible link with gastrointestinal (GI) cancers. This study aimed to…
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Artikel Jurnal
Nanomaterial-mediated modulation of gut microbiota for precision diagnosis and treatment of colorectal cancer: a comprehensive review
The critical role of gut microbiota in the initiation and progression of colorectal cancer (CRC) has garnered widespread recognition. Leveraging their precise targeting capabilities and programmable properties, nanomaterials are emerging as novel strategy for modulating the interplay between…
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Artikel Jurnal
Successful anesthesia management for middle cerebral artery thrombectomy in a patient with asynchronous cardio-cerebral infarction: a case report
BackgroundCardio-cerebral infarction (CCI) is a rare syndrome characterized by acute ischemic stroke (AIS) occurring shortly after acute myocardial infarction (AMI). Currently, there are no evidence-based guidelines for perioperative anesthesia management in patients with CCI.Case summaryA…
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Artikel Jurnal
Ciprofol injection in patients receiving non-invasive positive pressure ventilation: a retrospective study
ObjectThis study aims to compare the efficacy and safety of ciprofol versus propofol in sedation for patients undergoing non-invasive positive pressure ventilation (NPPV), with a focus on evaluating sedative efficiency and systematically comparing the incidence of respiratory depression…
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Artikel Jurnal
Review of clinical advances in the procedural sedation application of remimazolam
IntroductionWith the ongoing advancement of comfort-oriented healthcare, procedural sedation is increasingly applied in clinical practice. As a novel benzodiazepine derivative, remimazolam offers distinct advantages in procedural sedation. This paper aims to thoroughly examine its pharmacological…
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Artikel Jurnal
Network toxicology reveals key genes of amiodarone induced pulmonary fibrosis: based on machine learning and SHAP analysis
BackgroundAmiodarone (AMD), a highly effective Class III antiarrhythmic drug, has its clinical utility limited by the risk of inducing a serious adverse effect, amiodarone-induced pulmonary fibrosis (AIPF). The pathogenesis of AIPF remains poorly elucidated, particularly the hub driver genes, which…
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Artikel Jurnal
Adenosine A2A receptors regulate D2-type medium spiny neurons in the nucleus accumbens to mediate pain and depression comorbidity
Persistent pathological pain often induces comorbid depressive-like symptoms, yet the underlying neuronal and molecular mechanisms remain unclear. The nucleus accumbens shell (NAcS) has been implicated in mediating pain sensation and emotional disorders, including depression. However, how it…
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Artikel Jurnal
Chronic inflammation as a driving factor for sarcopenia: an update on pathophysiology and future therapeutic targets
Sarcopenia is a syndrome characterized by an age-related progressive decline in skeletal muscle mass, strength, and function. It represents a significant public health concern because of its adverse impact on the quality of life and prognosis of older adults. Chronic low-grade inflammation…
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Artikel Jurnal
Prospective evaluation of medication-related problems and pharmacist interventions in liver transplant recipients
BackgroundMedication-related problems (MRPs) are a common patient safety issue among hospitalized individuals, often associated with reduced quality of life, increased healthcare costs, and higher mortality. Due to the chronic and complex nature of post-transplant care, liver transplant recipients…
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Artikel Jurnal
Drug-associated insomnia and sex-specific disproportionality in the FDA adverse event reporting system (2019–Q1 2025)
Insomnia is a frequent and clinically relevant adverse drug reaction that can impair quality of life, treatment adherence and long-term outcomes. Evidence on drug-associated insomnia has largely been derived from selected clinical trial populations or focused on individual drug classes, while…
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Artikel Jurnal
Effects of rutin on renal function, oxidative stress and fibrosis in animal models of diabetic nephropathy: a systematic review and meta-analysis
BackgroundDiabetic nephropathy is a major microvascular complication of diabetes and a leading cause of end-stage renal disease, while effective disease-modifying therapies remain limited. Rutin, a naturally occurring flavonoid with antioxidant and anti-inflammatory properties, has shown…
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Artikel Jurnal
Different treatments for Crohn’s disease complicated by severe acute lower gastrointestinal bleeding: infliximab therapy is critical and cannot be ignored
ObjectiveAcute severe lower gastrointestinal bleeding (SLGIB) is one of the life-threatening complications of Crohn’s disease (CD) whose therapy is being optimized constantly. We aim to evaluate the therapeutic efficacies and economic benefits of different treatments for acute SLGIB in CD.MethodA…
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Artikel Jurnal
TAAR1-mediated pathways regulating nigrostriatal function and the discovery and pharmacological characterization of a novel TAAR1 agonist, Selutaront
IntroductionSchizophrenia is a severe neurodevelopmental disorder with limited treatment options. Trace amine-associated receptor 1 (TAAR1) has emerged as a promising therapeutic target, yet its downstream signaling mechanisms and the development of highly selective agonists remain incompletely…
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Acetylshikonin mitigates diet-induced MASLD by targeting PPARγ-mediated metabolic dysfunction
IntroductionThe liver, as the central metabolic hub of the body, is highly susceptible to diet-induced injury. The increasing prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) highlights the urgent need for effective clinical interventions. Currently, there are no…
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Artikel Jurnal
Risk assessment of drug-associated miscarriage using XGBoost and SHAP explainability: a real-world pharmacovigilance analysis based on the FAERS database
BackgroundMiscarriage is a common and serious adverse pregnancy outcome. Assessing drug-associated miscarriage risk is essential for medication safety in pregnancy. Using the FDA Adverse Event Reporting System this study systematically mined adverse drug events related to miscarriage and combined…
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