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Artikel Jurnal
Natural compounds as multitarget agents in Alzheimer’s diseases: evidence from in vivo and in vitro models
IntroductionAlzheimer’s disease (AD), the most common cause of dementia, is marked by a gradual decline in cognitive function driven by amyloid-β (Aβ) deposition, tau hyperphosphorylation, synaptic failure, neuroinflammatory responses, and mitochondrial dysfunction. Despite extensive research…
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Artikel Jurnal
Targeting the NSUN2–DHODH axis reverses ferroptosis resistance and oxaliplatin resistance in colorectal cancer
BackgroundOxaliplatin (OXA) is a standard chemotherapy for advanced colorectal cancer (CRC), yet acquired resistance frequently limits its efficacy. Ferroptosis, an iron-dependent form of cell death driven by lipid peroxidation, has emerged as a promising strategy to overcome chemoresistance. The…
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Artikel Jurnal
Network meta-analysis of pharmacological treatments for idiopathic pulmonary fibrosis: evaluating effects on lung function
BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrotic interstitial lung disease of unknown cause. Its main feature is a steady decline in lung function, which is also the primary target for treatment. Existing research has investigated various drugs to slow IPF…
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Artikel Jurnal
Hyperthermia-targeted rectal delivery of thermosensitive liposomal doxorubicin via intra-arterial and intravenous administration
IntroductionLyso-thermosensitive liposomal doxorubicin (LTLD) is a thermosensitive nanomedicine designed to release doxorubicin rapidly at mild hyperthermic temperatures. Unlike systemic doxorubicin, which is limited by cardiotoxicity and poor tumor penetration, LTLD enables targeted drug delivery…
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Artikel Jurnal
Comprehensive review of tujia “Lian” medicinal botanical drugs: traditional classification system, phytochemical, and pharmacological profile
Tujia medicine categorizes drugs with similar effects into several major classes based on their ordinal numbers, primarily using the 36 and 72 ordinal number systems for organization. The drugs that mainly function to dispel wind and cold, promote blood circulation and disperse blood stasis…
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Artikel Jurnal
Peripheral blood RNA-seq analysis in bipolar and schizophrenia spectrum disorders: modest influence of antipsychotic treatment
IntroductionBipolar disorder (BP) and schizophrenia spectrum disorders (SSD) are chronic mental health conditions that share genetic risks. Despite extensive research, the biological mechanisms underlying these disorders are still not fully understood.MethodsIn this study, we analyzed peripheral…
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Artikel Jurnal
Nervonic acid confers neuroprotection in a zebrafish model of diabetic neuropathy by promoting myelin repair and metabolic modulation
IntroductionDiabetic neuropathy (DN) is one of the most common and debilitating complications of type 2 diabetes mellitus (T2DM), yet effective therapeutic strategies remain limited. Nervonic acid (NA) is recognized for its neuroprotective and anti-inflammatory properties. However, its role in DN…
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Artikel Jurnal
Dietary strategies for chronic constipation: smartly targeting hormonal and reflex pathways for optimal recovery
Chronic constipation (CC) is a common disorder of gut-brain interaction that markedly impairs quality of life and remains challenging to manage. Despite the availability of laxatives and prosecretory agents, up to half of patients experience suboptimal relief, underscoring the need for…
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Artikel Jurnal
UHPLC-Q/TOF-MS-based differential metabolite screening and origins classification of Codonopsis Radix
IntroductionCodonopsis Radix (CR), also known as Dangshen, is a renowned plant native to China, highly valued for its unique medicinal properties. However, due to the existence of numerous closely related origins and the similarities in their interspecies traits, microscopic characteristics, and…
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Artikel Jurnal
Comparative safety profiles of risankizumab versus guselkumab: a pharmacovigilance study based on the FAERS database
BackgroundRisankizumab and guselkumab are two leading interleukin-23 (IL-23) inhibitors for treating immune-mediated inflammatory diseases. While effective, a direct comparison of their real-world safety profiles is lacking. Understanding the distinct differences in their adverse event (AE)…
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Artikel Jurnal
Quercetin attenuates acute alcohol-induced liver injury in mice by modulating lipid metabolism, oxidative stress, and inflammation
BackgroundAlcoholic liver disease (ALD) remains a major global health burden, and effective therapeutic options are limited. Quercetin, a dietary flavonoid with antioxidant and anti-inflammatory properties, has shown hepatoprotective potential, but its mechanisms in acute alcohol-induced liver…
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Artikel Jurnal
Formulation and in vitro evaluation of an anti-inflammatory herbal suppository containing Peperomia pellucida
IntroductionAdverse effects associated with the anti-inflammatory medicines highlight the need for safer alternatives. The present study aimed to evaluate the anti-inflammatory characteristics of Peperomia pellucida and to develop an anti-inflammatory herbal suppository using the plant…
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Artikel Jurnal
Stratification system for pharmaceutical care in cancer patients: Chinese expert consensus
BackgroundChina bears one of the world’s heaviest cancer burdens, with a complex and multimodal cancer treatment environment. Currently, the absence of a standardized framework for oncology pharmaceutical care limits the quality and precision of services, highlighting an urgent need for clinical…
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Artikel Jurnal
Preclinical approaches to studying liver and kidney fibrosis: models and methodologies
Organ fibrosis, notably affecting the liver and kidneys, remains a major contributor to global morbidity. This review examines the pathophysiology, molecular mechanisms, and preclinical models used to study hepatic and renal fibrosis. In liver fibrosis, hepatic stellate cell activation, chronic…
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Artikel Jurnal
Licoisoflavone B alleviates psoriasis via SCD1-targeted lipid metabolism reprogramming and suppression of Th17/IL-17–mediated inflammation
IntroductionPsoriasis is a chronic inflammatory skin disorder driven by dysregulated immune responses, Th17 cells activation, and keratinocytes hyperproliferation. Despite advances in therapies, high costs and adverse effects limit their utility. Licoisoflavone B (Lico B), bioactive flavonoid…
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Artikel Jurnal
Stage IIIB ROS1-Positive NSCLC management: crizotinib + surgery + TCM achieves exceptionally prolonged PFS (a case report)
This article reports a case of a patient with small primary foci (11 mm*8 mm), highly malignant ROS1 fusion-positive non-small cell lung cancer (NSCLC) with mediastinal and supraclavicular lymph node metastases. After neoadjuvant crizotinib targeted therapy, the patient underwent lobectomy and…
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Artikel Jurnal
Paclitaxel-induced germline DNA-damage signatures independent of mismatch repair in C. elegans
IntroductionPaclitaxel is a frontline chemotherapeutic agent that stabilizes microtubules, but its broader impact on germline genome stability and long-term tolerance mechanisms remains incompletely understood.MethodsUsing Caenorhabditis elegans, we combined phenotypic, cytological, genetic, and…
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Artikel Jurnal
Promising synergistic interactions and mixture optimization of safranal, crocin, and crocetin from Moroccan Crocus sativus L. with enhanced antimicrobial activity
This study explores the antimicrobial activity of three principal bioactive constituents of Crocus sativus L.—safranal, crocin, and crocetin—using a simplex-centroid mixture design to evaluate their individual and synergistic effects. Twelve formulations were tested against Staphylococcus aureus…
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