31,912 results
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Journal Article
Expanding the therapeutic landscape of minoxidil for androgenetic alopecia: topical, oral and sublingual formulations
Androgenetic alopecia (AGA) is the most common form of non-scarring alopecia, affecting up to 80% of men and 50% of women by the age of 70. Minoxidil, initially developed as an oral antihypertensive, has become one of the most widely used therapies for AGA due to its safety and efficacy. This…
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Journal Article
Research progress and controversies in the treatment of functional constipation-related depression with probiotics and prebiotics: a narrative review
Functional constipation (FC) commonly co-occurs with depression, with the microbiota–gut–brain axis providing a biological basis for this association. Designed as a narrative review employing systematic search strategies to ensure comprehensive coverage while accommodating evidence heterogeneity…
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Journal Article
Enhancement of gemcitabine toxicity and specificity through PI3K/Akt/Nrf2 pathway inhibition in pancreatic cancer
IntroductionPancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy associated with rapid metastasis and chemoresistance driven by PI3K/Akt/Nrf2 signalling and drug efflux transporters. The lack of symptoms and early diagnosis are clinically challenging, and the development of new…
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Journal Article
Malnutrition, cachexia and sarcopenia as susceptibility factors for cardiovascular complications in patients with cancer
Cancer remains a leading cause of morbidity and mortality, although cancer survivorship has increased impressively in the past decades. Patients with cancer often face cardiovascular complications, either due to cancer itself or due to anti-cancer therapy, that may affect their quality of life and…
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Journal Article
7α-acetoxy-6β-hydroxyroyleanone (Roy) modulates IL-6/STAT3/JAK2 mRNA expression and suppresses tumor growth in glioblastoma cell models
IntroductionGlioblastoma (GB) is the most aggressive primary glioma, with a median survival of 15-18 months. Current treatments are often ineffective, largely due to tumor heterogeneity and recurrence. Advances in understanding GB’s molecular landscape and microenvironment have highlighted new…
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Journal Article
A real-world study of adverse event profiles associated with the four key components of antibody–drug conjugates based on the FAERS database
BackgroundAntibody–drug conjugates (ADCs) exhibit structurally driven and highly heterogeneous toxicities, yet most pharmacovigilance studies remain drug-centered and lack systematic component-level evaluation. This study provides a comprehensive real-world safety assessment of FDA-approved ADCs…
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Journal Article
Effect of the antifungal drug ciclopirox on the inhibition of HMGA2-mediated oncogenic capacity in ACHN renal cell carcinoma
Ciclopirox olamine (CPX), an off-patent antifungal agent with a broad antimicrobial spectrum, is used to treat fungal infections. In addition to its antifungal effects, it inhibits tumor growth. However, little is known about the direct target proteins and anticancer mechanisms of CPX. The…
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Journal Article
Advances in the treatment of recurrent aphthous stomatitis: from synthetic and natural drugs to novel drug delivery systems
BackgroundRecurrent aphthous stomatitis (RAS), the most common inflammatory disease of the oral mucosa, has a complex etiology and diverse pathogenesis. To date, no curative treatment exists. Recurrent oral ulcers severely impair patients' quality of life, making the development of highly effective…
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Journal Article
Polydatin in respiratory diseases: multi-target mechanisms and therapeutic potential
Respiratory diseases constitute a heterogeneous group of disorders that primarily involve the lungs. Driven by worsening air pollution, tobacco use, occupational exposures, the COVID-19 pandemic, and population aging, they show persistently high incidence with rising mortality and disability…
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Journal Article
Comparison of maintenance with decitabine or chemotherapy in a real-world cohort of patients with acute myeloid leukemia
BackgroundThe objective of this real-world cohort study was to evaluate the efficacy and safety of decitabine versus conventional chemotherapy in the maintenance therapy (MT) of patients with acute myeloid leukemia (AML).MethodsData were collected from 156 consecutive patients diagnosed with AML at…
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Journal Article
Ferroptosis and cuproptosis in head and neck squamous cell carcinoma: interconnected mechanisms and therapeutic implications
Head and Neck Squamous Cell Carcinoma (HNSCC) is a highly prevalent malignant neoplasm worldwide. Iron and copper metabolism disorder regulate ferroptosis and cuproptosis, two forms of cell death, respectively, and play key roles in the progression and treatment response of HNSCC. Recent studies…
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Journal Article
Efficacy and safety of aflibercept biosimilars compared to aflibercept in the treatment of neovascular age-related macular degeneration: a systematic review and meta-analysis
BackgroundThis study aimed to evaluate the aflibercept biosimilars compared to the reference product aflibercept (Eylea®) in terms of efficacy, safety, and immunogenicity in patients with neovascular age-related macular degeneration (nAMD).MethodsWe searched PubMed, Web of Science, Cochrane…
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Journal Article
18ï ¢-Glycyrrhetinic acid suppresses glioblastoma by regulating p38 signaling pathway: an integrative approach combining network analysis, transcriptomics, and experimental assessment
BackgroundGlioblastoma (GBM) remains a therapeutic challenge with limited treatment options and poor prognosis. 18β-Glycyrrhetinic acid (GA), a natural metabolite from licorice, has shown anti-tumor potential, but its pharmacological effects in GBM and the underlying mechanisms require systematic…
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Journal Article
Farnesol, the farnesol pathway, and the immune-gut-brain axis
Experimental models and clinical evidence suggest that the gut and the central nervous system (CNS) interact in a multifactorial, bidirectional manner. A third player, the immune system, has recently been identified in these interactions, with research linking the gut microbiome to inflammatory…
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Journal Article
Pharmacological activation of SIRT1–AMPK by ginsenoside Rb1: a novel therapeutic strategy for pressure injury via dual suppression of ferroptosis and inflammation
BackgroundPressure injuries (PIs) are a major clinical problem, and current treatments offer limited efficacy. Ferroptosis-driven oxidative damage and chronic inflammation severely impair wound healing. Ginsenoside Rb1 (Rb1), a bioactive component of Panax ginseng, possesses antioxidant and…
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Journal Article
Efficacy and safety of Yingxin pill for stable angina pectoris with heart blood stasis obstruction syndrome: a randomized, single-blind, positive-controlled trial
ObjectiveTo evaluate the clinical efficacy and safety of Yingxin Pill (YXP) in patients with stable angina pectoris (SAP) and heart blood stasis obstruction syndrome.MethodsSixty patients were randomly assigned to either the experimental group (YXP plus conventional Western medicine) or the control…
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