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Artikel Jurnal
Disruption of estrogen signaling by developmental exposure to BPA and TBT causes long term functional deficits in zebrafish retina
Bisphenol A (BPA) and tributyltin (TBT) are two endocrine disrupting compounds (EDC) that have opposite effects on estrogen signaling. BPA is an estrogen agonist that binds to all estrogen receptor types. TBT is an aromatase inhibitor that binds to the enzyme aromatase, preventing the synthesis of…
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Artikel Jurnal
Ethnopharmacological considerations of plants traditionally used by local communities to manage maternal conditions in Tanzania: a scoping review
Ethnopharmacological relevanceDespite notable progress in maternal health and a reduction in maternal mortality rates, Tanzania still falls short of global targets. Local women increasingly use herbal medicine to manage maternal conditions, highlighting the need of documenting and evaluate these…
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Artikel Jurnal
Pharmacogenomics and genetic ancestry: an opportunity to transform clinical practice in Colombia
Pharmacogenomics has emerged as a clinically actionable discipline capable of reducing inter-individual variability in drug response, adverse drug reactions, and therapeutic failure. However, its real-world implementation remains constrained by a structural limitation: the predominance of…
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Artikel Jurnal
An ethnopharmacological assessment of medicinal plants in Malanje Municipality, Angola
BackgroundMalanje Municipality in north-central Angola harbors exceptional botanical and cultural diversity, yet remains poorly documented for traditional medicinal plant knowledge; this study provides the first systematic ethnopharmacological baseline to guide pharmacological prioritization…
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Artikel Jurnal
A thermosensitive hydrogel encapsulating 2-DG alleviates periodontitis by inhibiting glycolysis and effector response of Th17 cells
ObjectiveTo investigate the mechanism of Th17 cells in immunomodulation during periodontitis and develop a localized drug delivery system based on glycolysis inhibition for safer and more effective therapeutic interventions.MethodsPeriodontitis models were established via the use of IL17A-KO mice…
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Artikel Jurnal
Current perspectives on circadian regulation of mitochondrial dynamics in mood disorders and perioperative stress
Mitochondria act as a central integrative hub for oxidative phosphorylation, calcium homeostasis and metabolic signaling, reflecting their evolutionary origin from an α-proteobacterial endosymbiont. Although nearly 90% of their ancestral genes have been transferred to the nuclear genome, their role…
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Artikel Jurnal
Multi-target intervention mechanisms and prospects of the traditional Chinese medicine Scutellaria baicalensis georgi in Alzheimer’s disease
Alzheimer’s disease (AD) is one of the most prevalent central nervous system disorders affecting middle-aged and elderly populations. As a neurodegenerative disease, its primary clinical manifestations include memory impairment, cognitive dysfunction, and behavioral abnormalities. However, there…
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Artikel Jurnal
MSAT: a FAERS-informed heterogeneous graph neural network for pharmacovigilance prediction of Chinese materia medica–associated adverse drug reactions
BackgroundPost-marketing safety surveillance of Chinese Materia Medica (CMM) is challenged by multi-component chemical heterogeneity and the limited mechanistic interpretability of signals derived solely from spontaneous reports. The FDA Adverse Event Reporting System (FAERS) provides large-scale…
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Artikel Jurnal
Extracellular vesicles delivering TIMP-2 modulate MMP-1, MMP-2, and MMP-9 expression in human lung adenocarcinoma A549 cells
Background/ObjectivesExtracellular vesicles (EVs) carrying therapeutic cargos represent a promising strategy for cancer treatment by enabling the targeted delivery of genetic material directly to cancer cells. This study aimed to evaluate the effect of EVs loaded with the TIMP-2 gene on the…
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Artikel Jurnal
Epithelial-mesenchymal transition and sunitinib resistance in renal cell carcinoma: mechanisms and therapeutic strategies
Renal cell carcinoma (RCC) is a prevalent, highly aggressive malignant tumor that affects the urinary system. RCC has a pronounced propensity for metastasis. Despite the widespread use of sunitinib as first-line therapy for advanced RCC, the occurrence of primary and acquired resistance is frequent…
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Artikel Jurnal
Engeletin alleviates doxorubicin-induced cardiotoxicity via the AMPK pathway in mice
BackgroundThe extensively employed antineoplastic drug doxorubicin (DOX) is constrained in clinical utilization on account of its severe cardiotoxicity, and there persists a dearth of protective agents against doxorubicin-induced cardiotoxicity (DIC). Engeletin (ENG) is a natural product endowed…
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Artikel Jurnal
Genome agnostic, multi-level non-oncogene addiction-based systems pharmacology for rescuing metastatic relapsed/refractory neoplasias
Rescue therapies for relapsed/refractory (r/r) metastatic neoplasias present significant unmet needs. Tumor tissue editing regimen for 13 r/r tumor types, carcinomas, sarcomas and hematologic neoplasias, included in 15 phase I/II trials, nuclear/cytokine receptor agonists, pioglitazone, plus/minus…
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Artikel Jurnal
Inconsistent medication recommendations for immune-mediated inflammatory diseases across pregnancy, lactation, and paternal preconception: a guideline-based review
BackgroundImmune-mediated inflammatory diseases (IMIDs) often affect women of childbearing age. Since active inflammatory disease is related with impaired reproductive outcomes, effective disease control is crucial. Clinical guidelines aim to support evidence-based shared decision-making. However…
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Artikel Jurnal
Impact of the 2017 ACC/AHA hypertension guidelines on antihypertensive prescribing in the United States: real-world evidence from a nationally representative population
BackgroundHypertension (HTN) remains a major contributor to cardiovascular morbidity and mortality in the United States (US). The 2017 ACC/AHA HTN guidelines introduced major changes to diagnostic thresholds and treatment recommendations, including earlier pharmacological initiation and greater…
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Artikel Jurnal
A case report of a patient with advanced gastric adenocarcinoma who demonstrated excellent long-term sustained efficacy even after discontinuation of treatment following chemotherapy combined with claudin18.2 and PD-1 therapy
Gastric cancer is the fifth most common cancer and the third most common cause of cancer death globally. Patients with advanced gastric cancer have poor outcomes and short survival times. This case report presents a remarkable clinical response in a patient with advanced Epstein-Barr virus…
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Artikel Jurnal
Systems-level actions of luteolin in female reproductive disorders: from molecular mechanisms to clinical translation
Female reproductive disorders represent a major global health challenge. Despite their clinical heterogeneity, these conditions share core pathological mechanisms including oxidative stress, chronic inflammation, hormonal imbalance, metabolic dysfunction, extracellular matrix remodeling, and…
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