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Journal Article
Natural products as kinase inhibitors in lung cancer: molecular mechanisms, therapeutic potential, and clinical trials
Lung cancer remains a leading cause of cancer mortality worldwide, with current treatments often limited by toxicity and resistance. Dysregulated kinase signaling particularly involving EGFR, PI3K/AKT/mTOR, MAPK, and ALK pathways drives tumor growth, survival, and metastasis. While synthetic kinase…
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Journal Article
Analyzing antibacterial potential of bellamya bengalensis derived peptide-silver nanoparticle conjugates over surgical implant surfaces
IntroductionProsthetic Joint Infection (PJI) is a serious and potentially fatal consequence of total joint arthroplasty that is primarily due to the formation of bacterial biofilms on surgical orthopedic implants. Such orthopedic infections often face antibiotic resistance; therefore, novel…
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Journal Article
Comparative efficacy of intravenous, topical, and combined tranexamic acid in elderly patients with intertrochanteric fractures undergoing intramedullary nail fixation: a multicenter cohort study
BackgroundIntertrochanteric fractures in older adults are associated with substantial blood loss, but the optimal tranexamic acid (TXA) regimen remains unclear. Most hip fracture studies have evaluated single-route intravenous TXA versus placebo, with limited data on combined regimens, particularly…
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Journal Article
Visomitin as a differentiation-inducing therapeutic agent through SYK inhibition in AML
BackgroundAcute myeloid leukemia (AML) is an aggressive hematological malignancy characterized by the rapid proliferation of immature myeloblasts and resistance to apoptosis. Overcoming the differentiation block and apoptotic resistance remains a major challenge in AML therapy. Visomitin, a…
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A transdisciplinary framework for managing metabolic dysfunction associated steatotic liver disease
Metabolic dysfunction-associated steatotic liver disease (MASLD) is rapidly emerging as a public health issue across the globe. Its complex etiopathology and association with diverse comorbidities poses significant challenges to conventional pharmacological drugs derived from the “lock-and-key”…
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Journal Article
Polyphenolic compounds in Glycyrrhiza spp.: a potential weapon against multidrug-resistant pathogens
Antimicrobial resistance (AMR) is a rapidly escalating global health crisis, projected to cause 10 million deaths annually by 2050 without effective intervention. Conventional antibiotics are increasingly compromised by multidrug-resistant (MDR) pathogens that deploy mechanisms such as efflux…
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Journal Article
The spatiotemporal dynamic evolution of post-stroke neuroinflammation: energy metabolism mechanisms of acute response and chronic progression
Ischemia stroke is a highly disabling and fatal disease in China. Neuroinflammation is the predominant pathological change in ischemic stroke. Various immune cells such as microglia and T cells are involved in the process of brain tissue damage during ischemic stroke; they play different roles…
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Journal Article
Unraveling the anti-colorectal cancer mechanisms of Acanthopanax senticosus polysaccharide: a multi-omics investigation into gut microbiota-metabolism-immunity crosstalk
BackgroundThis study aimed to systematically investigate the anti-colorectal cancer efficacy and the underlying mechanisms of Acanthopanax senticosus polysaccharide with a focus on its role in modulating the gut microbiota-metabolism-immune axis.MethodsA homogeneous ASP fraction was structurally…
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Journal Article
Fibroblast growth factor receptor inhibitors in glioma: a narrative review of recent advances
Gliomas are devastating CNS malignancies characterized by extreme molecular heterogeneity and poor prognosis; the fibroblast growth factor receptor (FGFR) signaling axis, which drives proliferation, stemness, and metabolic adaptation, has thus emerged as a crucial therapeutic target. This review…
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Journal Article
Safe dosage and potential risks of chlorogenic acid: insights from in vitro and in vivo studies
IntroductionAs the economy grows, there is a growing emphasis on food safety. While the health benefits of chlorogenic acid (CGA) are recognized, safe dosages and potential liver cell damage from excessive CGA consumption are not well studied. This study aims to determine the safe and effective…
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Journal Article
Huangkui capsule mitigates diabetic nephropathy via epigenetic therapy effects
BackgroundHuangkui capsule (HKC), a Chinese herbal medicine derived from Abelmoschus manihot (L.) ethanol extract, has clinical efficacy against diabetic nephropathy (DN). Our research group has actively engaged in exploring the efficacy of HKC in treating DN. The underlying pharmacological…
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Journal Article
Clinical efficacy and mechanistic study of fulvning granules in symptomatic atrial fibrillation: a randomized controlled trial with untargeted metabolomics analysis
BackgroundAtrial fibrillation (AF) is the most prevalent sustained arrhythmia and a leading cause of morbidity and mortality worldwide. Although antiarrhythmic drugs and catheter ablation have improved AF management, their therapeutic efficacy remains suboptimal. Fulvning Granules (FLN), a…
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Journal Article
Antibody-enabled structural biology and AI-driven antibody design
Membrane proteins govern essential cellular processes, including ion transport, signal transduction, and molecular recognition, and collectively represent more than half of all current therapeutic targets. Yet their structural characterization remains challenging due to intrinsic instability…
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Journal Article
Early administration of shenfu injection for the incidence of sepsis-induced cardiomyopathy in septic patients: a randomized controlled trial
BackgroundSepsis-induced cardiomyopathy (SIC) is a severe complication of sepsis that markedly increases mortality. Owing to its complex pathogenesis, no targeted drugs for SIC is currently available, highlighting the need for preventive interventions. This study aimed to evaluate whether early…
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Journal Article
Ketoprofen-loaded quatsomes as a smart repurposed antifungal therapy for vaginal infections: formulation, characterization, and microbiological evaluation
IntroductionVulvovaginal candidiasis (VVC) is one of the most common fungal infections requiring more effective and patient-friendly therapies. This study introduces repurposed Ketoprofen (KPN) Quatsomes (QS) as a novel nano-platform for localized antifungal treatment.MethodsKPN-QS were prepared…
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Journal Article
Epidemiological relevant effect biomarkers for thyroid hormone system related adverse outcome pathways: a literature review
BackgroundMany factors, such as lifestyle, medication, and environmental exposures, are reported to cause thyroid hormone system disruption (THSD) in humans, however studies linking THSD to health effects are sparse. Adverse Outcome Pathways (AOPs) provide mechanistic links from molecular events to…
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Journal Article
The role of immune regulation in peripheral nerve regeneration: functions of inflammatory cells and cytokines
BackgroundThe regenerative repair following peripheral nerve injury is a complex pathophysiological process in which the immune regulatory network plays a crucial role. Conventional understanding posits that inflammatory responses impede nerve regeneration; however, recent studies reveal that…
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Journal Article
Investigations of the voltage-gated Ca++ channels and phosphodiesterase enzyme inhibitory-like potential explain the medicinal use of Otostegia fruticosa in diarrhea and hypermotile gut
BackgroundThe leaves of Otostegia fruticosa have been used in traditional medical systems to treat diarrhea and gut spasms. In this study, we evaluate the possible gut inhibitory roles of the crude extract of O. fruticosa using mice for in vivo, rabbits for ex vivo, and selected enteric pathogenic…
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Journal Article
A proposed closed-loop framework for postoperative management of OVCF integrating biosensor-enabled monitoring and traditional Chinese medicine formulas: from dynamic assessment to precision intervention
Postoperative management of osteoporotic vertebral compression fracture (OVCF) remains challenging because conventional bone mineral density (BMD) and imaging assessments are intrinsically delayed, while bone turnover markers (BTMs) that reflect real-time remodeling dynamics are difficult to…
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