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Artikel Jurnal
Prevalence and predictors of analgesic use during early pregnancy in a Brazilian population
IntroductionAlthough the use of analgesics is generally not recommended during pregnancy, several studies have reported a high prevalence of use among pregnant women. In this study, we assessed the prevalence of early pregnancy use of analgesics in a Brazilian population, as well as potential…
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Artikel Jurnal
Uncaria rhynchophylla: an ethnopharmacological review integrating traditional Chinese medicine uses with phytochemical and pharmacological evidence
Uncaria rhynchophylla (Miq.) Jacks. (UR), a climbing shrub of the Rubiaceae family, has been a foundational remedy in traditional Chinese medicine for over 1,500 years, and has long been used to treat neurological disorders, hypertension, and inflammatory conditions associated with “Liver Wind” and…
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Artikel Jurnal
Pyrimidine nucleoside: inspiration for novel antimicrobial agent
Antimicrobial resistance (AMR) is a worsening global health crisis, with drug repurposing emerging as a key mitigation strategy. Pyrimidine nucleosides are promising antibacterial scaffolds due to their easily modifiable structures and multi-therapeutic potential. However, related research faces…
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Artikel Jurnal
Low-dose dexmedetomidine improves postoperative sleep and pain in gynecological surgery: a randomized trial
BackgroundPostoperative sleep disturbances often lead to a vicious cycle with pain, severely hindering the recovery of patients. Women, due to fluctuations in sex hormones and their unique pain modulation mechanisms, are particularly vulnerable to both postoperative sleep disorders and pain…
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Artikel Jurnal
Multifaceted mechanisms of plant metabolites in pulmonary arterial hypertension: a critical review beyond vasodilation
Pulmonary arterial hypertension (PAH) is a progressive vascular disease characterized by remodeling, inflammation, and metabolic dysregulation. Current pharmacotherapies primarily target vasodilation but fail to reverse structural remodeling or arrest disease progression. Plant metabolites have…
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Artikel Jurnal
Profiles of neuropsychiatric toxicity associated with different endocrine therapies for breast cancer: a global pharmacovigilance study based on FAERS and VigiAccess
PurposeBreast cancer is the most common malignancy in women. Hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer patients rely on endocrine therapy as their fundamental systemic treatment strategy. This study aims to comprehensively evaluate the…
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Artikel Jurnal
Early biomarkers for predicting sepsis-induced shock: insights from inflammatory pathways and immune response
Severe sepsis-induced shock is one of the most challenging problems in critical care despite the progress made in treatment. Recognizing high-risk patients early on is critical for successful results, and the standard diagnostic approaches to such an ailment fail to identify it prior to shock…
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Artikel Jurnal
Beyond blood pressure: the renin-angiotensin system as an innovative driver and therapeutic target in pathological scarring
Pathological scarring, a fibroproliferative disorder, imposes a substantial burden on affected individuals. This review explores the pivotal role of the local cutaneous renin-angiotensin system (RAS) in the pathogenesis of pathological scarring. We summarize evidence demonstrating how the…
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Artikel Jurnal
Effects of combining Shugan Jieyu capsule treatment with group psychological counseling on alexithymia in hemodialysis patients
AimTo explore the effects of combining Shugan Jieyu capsule treatment with group psychological counseling on alexithymia in patients undergoing hemodialysis.MethodsA total of 120 patients with nephropathy who underwent hemodialysis at our hospital’s dialysis center from January 2023 to December…
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Artikel Jurnal
Fatty acid–related immune network in psoriasis: metabolic regulation of innate and adaptive immunity
Psoriasis is a chronic inflammatory skin disorder driven by dysregulation of the Treg/Th17 axis, where enhanced Th17 activity promotes keratinocyte proliferation and inflammation, while impaired Treg function exacerbates immune dysregulation. Emerging evidence highlights peroxisome…
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Artikel Jurnal
IncRNAs transcriptomics elucidates the potential mechanism of Naoshuantong capsule in alleviating synaptic dysfunction in a murine model of cerebral ischemia/reperfusion injury
BackgroundNaoshuantong capsule (NST), a Traditional Chinese Medicine formulation, is used for ischemic stroke treatment; however, its molecular mechanisms are unclear. This study aimed to investigate the mechanistic basis of NST using long noncoding RNA (lncRNA) and messenger RNA (mRNA)…
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Artikel Jurnal
Febuxostat effectively reduces uric acid but has a limited renoprotective effect on renal transplant recipients with hyperuricemia: a meta-analysis
ObjectiveSeveral previous studies have indicated that febuxostat can reduce uric acid (UA) levels and has a renoprotective effect on renal transplant recipients with hyperuricemia, but a comprehensive analysis of this effect is lacking. This meta-analysis aimed to analyze the effects of febuxostat…
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Artikel Jurnal
Esketamine-based PCIA combined with intercostal nerve block for acute pain after lobectomy: a randomized controlled trial
ObjectiveTo evaluate outcomes of different doses of esketamine in postoperative patient-controlled intravenous analgesia (PCIA) combined with preoperative intercostal nerve block (ICNB) analgesia protocol for acute postoperative pain (APP) relief in patients undergoing thoracoscopic…
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Artikel Jurnal
Efficacy and safety of immune checkpoint inhibitors combined with chemoradiotherapy in locally advanced cervical cancer: a systematic review and meta-analysis
BackgroundLocally advanced cervical cancer (LACC) remains a leading cause of cancer-related morbidity and mortality, especially in low- and middle-income countries. While concurrent chemoradiotherapy (CCRT) is the standard of care for LACC, recurrence rates remain high, and the survival outcomes…
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Artikel Jurnal
A retrospective analysis of outpatient use of small-molecule targeted inhibitors for lymphoma across six regions of China (2016–2022)
ObjectiveThis study aimed to assess national trends in prescription volumes, drug expenditures, and the pharmacoeconomic rationality of small-molecule targeted inhibitors used for lymphoma treatment among outpatients in China between 2016 and 2022.MethodsOutpatient prescription data for patients…
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Artikel Jurnal
AI-driven pilot platforms and computational pharmaceutics: accelerating innovation in small molecule drug development under industry 4.0 and 5.0 paradigms
In the era of artificial intelligence (AI) and Industry 4.0, pilot-scale platforms for small molecule chemical drugs are undergoing a transformative digital evolution. These platforms serve as a critical link between early-stage laboratory research and full-scale pharmaceutical manufacturing…
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Artikel Jurnal
Real-world evidence for atropine titration in myopia control: a comparative study of three low-dose regimens in Chinese children
PurposeTo evaluate and compare the efficacy of 0.01%, 0.025%, and 0.05% atropine eye drops in slowing myopia progression among Chinese children aged 6–18 years, focusing on changes in spherical equivalent (SE) and axial length (AL).MethodsIn this prospective, real world based, multi-center study…
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Artikel Jurnal
Addressing clinical uncertainties in ATMP reimbursement: a review of methodological guidelines and European practice
IntroductionAdvanced Therapy Medicinal Products (ATMPs) often present substantial clinical uncertainties at the time of reimbursement evaluation, particularly due to the lack of appropriate comparators and the absence of long-term clinical endpoints. This study primarily examined two methodological…
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Artikel Jurnal
Double-edged-sword effect of bisphosphonates on the osteogenic differentiation of human periodontal ligament stem cells
Bisphosphonates (BPs), widely used anti-resorptive agents for osteoporosis and cancer-related bone metastasis, can paradoxically contribute to medication-related osteonecrosis of the jaw (MRONJ). Our previous work showed that periodontal ligament stem cells (PDLSCs) from MRONJ patients display…
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Artikel Jurnal
Anticoagulant-free preparation of autologous platelet-rich plasma (PRP) / fluid platelet-rich fibrin (f-PRF): a pre-clinical comparative performance study
ObjectiveThis study aimed to validate and characterize the efficacy of a previously developed anticoagulant-free, single soft-spin centrifugation device for the preparation of autologous fluid-Platelet-Rich Fibrin (f-PRF).Introductionf-PRF is generated via one-step soft-spin centrifugation of all…
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