31.912 hasil
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Artikel Jurnal
Drug-induced male infertility: a real-world study using FAERS and EudraVigilance databases
ObjectiveTo systematically identify medications potentially causing male infertility or sperm abnormalities and provide risk alerts for clinical practice.MethodsA pharmacovigilance study was conducted using the FAERS database (Q1 2004–Q2 2025) and EudraVigilance (EV) database (January 2002–October…
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Artikel Jurnal
The ability of SABRE, a new quantitative receptor function model, to quantify receptor binding from even challenging concentration-effect data with a single unified fit
The Signal Amplification, Binding affinity, and Receptor-activation Efficacy (SABRE) model is the most recent general and quantitative model of receptor function. A specific extension of the SABRE model enables the determination of Kd (the equilibrium dissociation constant of the agonist-receptor…
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Artikel Jurnal
Legislating novel psychoactive substances: lessons from 15 years of UK mortality data (2007-2022)
BackgroundNovel Psychoactive Substances (NPS) emerged in the early 2000s as chemically designed alternatives to circumvent laws which internationally control drugs. There is limited evidence that NPS are produced in the UK, whereas China has long been recognised as a primary source of NPS. This…
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Artikel Jurnal
Mechanisms and safety evaluation of stir-fried atractylodis macrocephalae rhizoma with aurantii fructus in the treatment of inflammatory bowel disease: a study based on organ-on-a-chip model
BackgroundStir-fried atractylodis macrocephalae rhizoma (AMR) with aurantii fructus (AF) (SFALCA), a classical prescription of traditional Chinese medicine (TCM), has been widely used for promoting gastrointestinal health for centuries, with multiple pharmacological properties such as anti-tumor…
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Artikel Jurnal
From venom peptides to neurotherapeutics: BmK defensins and short-chain peptides as modulators of ion channels
Scorpions, having inhabited the Earth long before the emergence of humans, represent an ancient lineage of arthropods. While often regarded with fear due to their potential to induce severe pain or fatal envenomation, scorpion venoms constitute complex cocktails of bioactive molecules known as…
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Artikel Jurnal
Data-driven strategies for immunoradiotherapy in uveal melanoma: the role of artificial intelligence
Uveal melanoma (UM) represents the most common primary intraocular malignancy in adults and remains a formidable clinical challenge due to its high metastatic potential and characteristically limited response to conventional systemic therapies. While the combination of radiotherapy and…
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Artikel Jurnal
Natural products modulate programmed cell death signaling mechanism for treating endometriosis: a review
Endometriosis (EMs) is a gynecological inflammatory disease that depends on estrogen. Its chief symptoms include dysmenorrhea, chronic pelvic pain, reduced fertility, and pelvic masses. Although various hormonal therapies and surgical treatments are available, their long-term effectiveness is…
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Artikel Jurnal
The incidence of chronic drug-induced liver injury: a systematic review and meta-analysis
ObjectivesDrug-induced liver injury (DILI) is a recognized adverse drug event. Although most cases present with acute hepatic damage, evidence indicates that a proportion progress to persistent liver injury. The absence of a standardized definition for chronic DILI has contributed to significant…
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Artikel Jurnal
Advancing ulcerative colitis therapy: a review of 5-ASA synergy with traditional Chinese medicine and natural bioactive compounds
5-Aminosalicylic acid (5-ASA) is a first-line drug for the treatment of mild to moderate ulcerative colitis (UC), yet its monotherapy efficacy remains limited. In recent years, the combination of 5-ASA with bioactive components of traditional Chinese medicine (TCM) has emerged as an important…
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Artikel Jurnal
Efficacy of selected dietary supplements and pharmacological agents on metabolic and oxidative stress outcomes in metabolic dysfunction–associated fatty liver disease (MAFLD): a Bayesian network meta-analysis
ObjectiveThis study aimed to compare the relative efficacy of dietary supplements and pharmacological agents in improving metabolic and oxidative stress outcomes in patients with metabolic dysfunction-associated fatty liver disease (MAFLD) through a systematic review and Bayesian network…
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Artikel Jurnal
Protective effects of curcumin against chemical-induced toxicity in the male reproductive system: a systematic review
BackgroundCurcumin is a biologically active substance present in turmeric. It has recently been suggested for its protective potential against a wide variety of chemical-induced toxicities.PurposeThis systematic review aims to summarize current evidence on the protective effects of curcumin against…
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Artikel Jurnal
Beneficial effects of berberine in the treatment of diabetes and its complications
Coptis chinensis (Huanglian), a key component in numerous classical Chinese herbal formulas, is traditionally applied for treating metabolic diseases based on its activity including clear heat, dry dampness, purge fire, and detoxify. Berberine (BBR), one key active component from Coptis chinensis…
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Artikel Jurnal
Immunotherapy-related cardiovascular toxicity: from mechanisms to management
Cancer immunotherapy, including immune checkpoint inhibitors and CAR-T cell therapy, has revolutionized oncology but is associated with a broad spectrum of cardiovascular toxicities. This review comprehensively examines the current landscape of these adverse events, which range from myocarditis…
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Artikel Jurnal
Association of serum methylglyoxal with endothelial dysfunction in patients with type 2 diabetes
AimsTo explore the correlation between serum Methylglyoxal (MGO) and endothelial dysfunction in patients with type 2 diabetes mellitus, and to evaluate the clinical value of MGO in the development of diabetes mellitus and its complications.MethodsIn this cross-sectional study, we enrolled 250…
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Artikel Jurnal
Efficacy and safety of ivonescimab in non-small cell lung cancer: a systematic review and meta-analysis of emerging clinical data
IntroductionIvonescimab (AK112), a novel bispecific antibody targeting PD-1 and VEGF, has emerged as a promising therapeutic agent in the treatment of non-small cell lung cancer (NSCLC). This study aims to comprehensively evaluate its efficacy and safety.Materials and methodsA comprehensive…
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Artikel Jurnal
Dietary dihydroquercetin alleviates age-related cognitive impairment in association with modulation of apoptosis and pyroptosis pathways
With the intensification of population aging, age-related cognitive decline has emerged as a significant global health issue. Neuroinflammation, neuronal apoptosis, and pyroptosis have been identified as key factors in neuronal loss, a hallmark of age-related neurodegenerative conditions…
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Artikel Jurnal
Beyond antipsychotic efficacy and toward an individualized therapeutic strategy: analysis of the systemic, metabolic, and inflammatory effects of olanzapine, haloperidol, and their combination in schizophrenic patients
IntroductionOlanzapine (OLZ), haloperidol (HALP), and their combination, are widely used antipsychotics; the majority of studies focuses on their therapeutic efficacy, leaving significant gaps in understanding their systemic impacts. Hence, the present study was conducted to investigate their…
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