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Artikel Jurnal
Therapeutic potential of pycnogenol: antioxidant, anti-inflammatory, immunomodulatory, antiviral, and anticancer effects
Pycnogenol (PYC), a standardized extract derived from the bark of the French maritime pine (Pinus pinaster ssp. atlantica), exhibits a broad spectrum of biological activities, including antioxidant, anti-inflammatory, immunomodulatory, antiviral, and anticancer effects. These effects are attributed…
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Artikel Jurnal
Triglyceride-glucose index and its derivatives as emerging biomarkers of insulin resistance for prognostic evaluation of cardiovascular-kidney-metabolic syndrome: mechanisms and clinical applications
Cardiovascular-Kidney-Metabolic Syndrome (CKM Syndrome) is a complex, multi-organ disorder characterized by metabolic dysfunction, involving the cardiovascular, renal, and metabolic systems. The components of CKM Syndrome exhibit significant interactions, driving the progression of multi-organ…
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Artikel Jurnal
hnRNP A2B1 as a promising therapeutic target for radiomodulatory drug development: evidence from computational and experimental studies
Radiation modulation is critical due to the growing risks of radiation exposure in medical, occupational, and environmental settings. This study explored the potential of heterogeneous nuclear ribonucleoproteins (hnRNPs), particularly hnRNP A2B1, as therapeutic targets for radiomodulatory drugs. In…
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Artikel Jurnal
Pharmacological effects and mechanisms of curcumin in animal models of Parkinson’s disease: a systematic review and meta-analysis
BackgroundCurcumin has been demonstrated to possess promising neuroprotective potential in Parkinson’s disease; however, its overall effects remain inconclusive, and its multiple mechanisms of action have not been systematically summarized.ObjectiveThis systematic review and meta-analysis aimed to…
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Artikel Jurnal
Eubacterium sp. mediates the anti-obesity effect of lotus leaf extract via brown adipose tissue activation and white fat browning
Nelumbinis folium [Nelumbonaceae; Nelumbo nucifera Gaertn.] is a traditional Chinese medicine. Although studies have reported the efficacy of lotus leaf in weight management, the underlying molecular pathways necessitate further studies. This study aimed to elucidate the effects of lotus leaf on…
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Artikel Jurnal
Total alkaloids of Leonurus alleviate allergic asthma and inflammation responses by inhibiting hypoxia-induced factor-1⍺-mediated mast cell activation
BackgroundLeonurus japonicus Houtt. has been traditionally used as a gynecological remedy and is now recognized for its anti-inflammatory and immunomodulatory properties. But its potential therapeutic role in allergic asthma is unclear. This study aimed to investigate the anti-asthmatic effects of…
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Artikel Jurnal
3D-QSAR study for the development of chalcone-based inhibitors targeting ovarian cancer cells with experimental validation
BackgroundOvarian cancer remains one of the most lethal gynecological malignancies, mainly due to late-stage diagnosis and frequent chemoresistance.PurposeThis study sought to develop 3D-QSAR models—Comparative Molecular Field and Similarity Index Analysis (CoMFA and CoMSIA)—to predict the…
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Artikel Jurnal
Metabolic profiling of the TME uncovers the contrasting impacts of CKMT2 and PDE2A in CRC progression and therapeutic response
BackgroundColorectal cancer (CRC) remains a major cause of cancer-related morbidity and mortality, with high recurrence rates and limited treatment options for metastatic disease. The tumor microenvironment (TME) and metabolic reprogramming are critical drivers of CRC progression, influencing…
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AP39 alleviates HHCY-induced myocardial remodeling by regulating FUNDC1-mediated mitochondrial dynamics via S-sulfhydration of NEDD8/CUL4B
IntroductionHyperhomocysteinemia (HHCY) is a well-recognized risk factor for cardiovascular diseases; however, the molecular mechanisms underlying HHCY-induced myocardial remodeling remain unclear. This study aimed to investigate the role of mitochondrial dysfunction and cardiomyocyte senescence in…
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Artikel Jurnal
Price transparency of cancer medicines: a crucial step towards informed pricing negotiations in the European region
BackgroundThe increasing cost of cancer medicines is a growing concern for hospitals in the European region, leading to cost reduction strategies, such as price negotiations. The objective of this study is to compare actual prices and discounts of cancer medicines at hospital level across the…
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Artikel Jurnal
Enhancing the rational use of sodium valproate in neurosurgery: a pharmacist-led PDCA intervention
Background and ObjectiveInappropriate use of sodium valproate (VPA) for seizure prophylaxis in neurosurgery poses clinical risks and increases healthcare costs. This study aimed to evaluate the effectiveness of a clinical pharmacist-led intervention, integrated with the Plan-Do-Check-Act (PDCA)…
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Artikel Jurnal
In silico and in vitro investigations of the drug–drug interaction mechanisms between fludarabine and busulfan
BackgroundUnderstanding drug interactions in hematopoietic stem cell transplantation (HSCT) is crucial given the narrow therapeutic index of busulfan (BU), which is a key conditioning agent. In this study, we investigate the potential impacts of fludarabine (Flu) as a frequently co-administered…
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Artikel Jurnal
Risk factors for drug-related gastrointestinal ulcer:a retrospective pharmacovigilance study
ObjectiveDespite the fact that many medications have been linked to gastrointestinal ulcers, the extent to which most of these drugs contribute to such ulcers is not well understood. This study investigates the risk factors linked to gastrointestinal ulcers caused by drugs by analyzing large…
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Artikel Jurnal
Vicenin-2 attenuates rosacea-like inflammation by inhibiting IL-17RA signaling
IntroductionRosacea is a persistent inflammatory dermatosis with a multifactorial etiology that significantly impairs patients’ daily life and wellbeing. Vicenin-2, a natural flavonoid, has shown anti-inflammatory potential; however, its therapeutic mechanism in rosacea remains unclear. We seek to…
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Artikel Jurnal
AI-driven identification of nutrition-modulated biomarkers and drug targets for cardiovascular therapeutic mechanisms
Cardiovascular diseases (CVD) remain the leading cause of disease burden and mortality worldwide. Despite significant progress in drug treatment, this situation indicates that persistent residual risks still exist even after all feasible risk control measures have been implemented. Nutrition is…
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Artikel Jurnal
Cluster of differentiation 38 monoclonal antibody therapy in the treatment of multiple myeloma: a systematic review and meta-analysis
BackgroundCluster of differentiation 38 (CD38) monoclonal antibodies, including daratumumab and isatuximab, have demonstrated clinical activity in relapsed or refractory multiple myeloma (MM). This study aims to systematically evaluate the efficacy and safety of CD38-targeted monoclonal antibodies…
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Artikel Jurnal
The therapeutic potential of Myoki, a novel peptide in muscle atrophy: mechanisms and applications
BackgroundWith the global population rapidly aging, the prevalence of sarcopenia, referring to a progressive loss of skeletal muscle mass and strength, is increasing, highlighting the need for effective preventive and therapeutic strategies. In this study, we evaluated the efficacy of Myoki, a…
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Artikel Jurnal
Clinical efficacy and safety of icaritin in patients with hepatocellular carcinoma: a real-world study
BackgroundIcaritin, a natural compound extracted from Epimedium, has demonstrated efficacy and a favorable safety profile in treating hepatocellular carcinoma (HCC), providing an option for patients intolerant to conventional treatment. However, real-world data remain limited. To assess the…
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Artikel Jurnal
Dimethyl fumarate and mitochondrial physiology: implications for neurological disorders
Dimethyl fumarate (DMF; C6H8O4) is an ester of fumaric acid widely used in clinical practice for the treatment of relapsing forms of multiple sclerosis and plaque psoriasis. Beyond its established immunomodulatory actions, DMF is increasingly recognized as a small molecule capable of reshaping…
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Artikel Jurnal
ACT001 synergizes with temozolomide-based chemoradiotherapy to cure refractory glioblastoma by targeting TNF-CXCL10-CD8+ T-cell immunity
Glioblastoma multiforme (GBM), a highly invasive brain tumor, is severely restricted in T-cell infiltration and anti-tumor activity due to its immunosuppressive microenvironment. However, commonly used preclinical GBM mouse models cannot fully recapitulate the refractoriness of human GBM or…
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