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Artikel Jurnal
Age and gender disparities in oral anticoagulant use: a nine-year nationwide drug utilization analysis
BackgroundCardiovascular diseases remain the leading cause of mortality in Europe, responsible for one-third of all deaths in 2021. In Hungary, the standardized death rate from cardiovascular diseases reached 722.8 per 100,000 individuals, more than double the EU average. Oral anticoagulants (OACs)…
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Artikel Jurnal
Remdesivir in COVID-19: pros and cons
BackgroundBeginning in late 2019, the COVID-19 pandemic caused by SARS-CoV-2 rapidly evolved into a global health crisis. High rates of severe illness, hospitalizations, and long-term complications highlighted an urgent need for effective therapeutic agents. This necessity drove unprecedented…
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Artikel Jurnal
Inhibiting the pathological changes of PASMCs is an effective approach for medicinal plants or secondary metabolites in treating pulmonary hypertension
Pulmonary hypertension (PH) is a progressive cardiovascular disease characterized by increased pulmonary vascular resistance and structural remodeling of pulmonary vessels, leading to poor clinical outcomes and high mortality. pulmonary artery smooth muscle cells (PASMCs) migration, apoptosis and…
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Artikel Jurnal
Parabrachial calcitonin gene-related peptide neurons sex-specifically modulate behavior in anxiety assays during alcohol withdrawal
Parabrachial nucleus (PBN) neurons expressing Calcitonin Gene-Related Peptide (CGRP) modulate fear- and anxiety-like behavior. It is unknown if PBN(CGRP) neurons play a role in anxiety during withdrawal from alcohol or after repeated stress. First, to investigate the anxiogenic role of activating…
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Artikel Jurnal
AUM-302, a novel triple PIM/PI3K/mTOR inhibitor, synergizes with RAS inhibition and impedes the growth of pancreatic ductal adenocarcinoma spheroids and organoids
Pancreatic ductal adenocarcinoma (PDAC) is a significant contributor to cancer-related deaths in the United States. The limited number of well-defined, druggable targets in PDAC has hindered the development of effective treatments. The PIM/PI3K/mTOR pathways, which regulate cell growth, apoptosis…
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Artikel Jurnal
Review of neuroprotective potential of natural products against hypoxia-induced neuronal injury
Neurological disorders such as neurodegenerative diseases (NDDs) and stroke have become a major global health burden. Evidences from several studies suggest that their pathogenesis is related to hypoxia. However, there are certain limitations and adverse effects associated with the current…
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Artikel Jurnal
LYVE-1 identifies asthma and drives PDGF-BB-induced proliferation, migration, and oxidative stress in airway smooth muscle cells via the PI3K/Akt pathway
BackgroundAsthma is a chronic inflammatory airway disease characterized by airflow limitations, airway remodeling, and immune dysregulation. Lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) has recently been implicated in inflammatory and remodeling processes in the body. However, its…
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Artikel Jurnal
Efficacy and safety of traditional Chinese classic prescriptions combined with metformin in the treatment of type 2 diabetes mellitus: a Bayesian network meta-analysis
BackgroundType 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by chronic hyperglycemia. While biomedicine (e.g., metformin) serves as the first-line treatment, combination therapies involving botanical drugs are increasingly utilized. However, the comparative efficacy of different…
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Artikel Jurnal
Plant polysaccharides in neuroprotection: mechanistic insights across central nervous system disorders
Central nervous system (CNS) disorders pose a major global health burden, and the limited efficacy and adverse effects of current pharmacotherapies underscore the need for more effective therapeutic strategies. Plant polysaccharides, as key bioactive metabolites of medicinal plants, have attracted…
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Artikel Jurnal
Miquelianin and spiraeoside from Filipendula ulmaria mitigate α-synuclein accumulation in C.elegans and reduce the expression of neuroinflammatory cytokines in human microglia
IntroductionChronic neuroinflammation and impaired proteostasis are increasingly recognized as interconnected drivers of Parkinson’s disease (PD). Due to their pleiotropic character, multicomponent herbal remedies combining anti-inflammatory and proteostatic activity may counteract these…
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Artikel Jurnal
Use of genetics in the prediction of success in male pattern hair loss therapy and mechanistic studies
Male pattern hair loss, the clinical manifestation of androgenetic alopecia in men, is a highly prevalent chronic condition associated with significant psychosocial burden, yet current therapies show heterogeneous efficacy and tolerability between individuals. Over the past decade, genome wide…
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Artikel Jurnal
Platelet-rich plasma for the treatment of postoperative anastomotic fistula of the gastrointestinal tract: a case report
IntroductionAnastomotic fistulas are a possible complication of local digestive tract resections, and their main symptoms include abdominal pain, peritonitis, and infections. Currently, the treatment of anastomotic fistulas is primarily conservative or involves surgical repair. Platelet-rich plasma…
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Artikel Jurnal
Innate immune signalling, neuroinflammation and network plasticity in temporal lobe epilepsy
Temporal lobe epilepsy emerges from a cascade of molecular, cellular, and structural disturbances triggered by heterogeneous cerebral insults—including convulsive status epilepticus, viral encephalitis, traumatic brain injury, and blood–brain barrier disruption—that converge on progressive…
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Artikel Jurnal
Advances in pharmacokinetic-pharmacodynamic modeling for anesthesia, 1987–2024: a review
In the field of individualized anesthesia, pharmacokinetic-pharmacodynamic (PKPD) models are crucial as they assist in determining the appropriate dosage for various patient groups. This research reviews the development of primary PKPD anesthetic models proposed in the literature from 1987 to 2024…
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Artikel Jurnal
Research progress on mechanisms and applications of Chinese herbal pairs in treating hyperplasia of mammary gland
Hyperplasia of Mammary gland (HMG), a common gynecological disorder with potential malignant transformation risk, has been effectively treated using Traditional Chinese Medicine (TCM) herbal pairs. This systematic review explores the therapeutic effects and underlying mechanisms of eight classic…
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Artikel Jurnal
Oleaceae plants: a source of metabolites with atheroprotective potential
Atherosclerosis is a leading cause of cardiovascular morbidity and mortality, driven by chronic inflammation, oxidative stress, lipid imbalance, and plaque instability. Bioactive metabolites found in plants of the Oleaceae family, particularly olives (Olea europaea L.), have emerged as promising…
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Artikel Jurnal
From dopamine to muscarine: xanomeline-trospium (KarXT) as a novel direction in the psychopharmacotherapy of schizophrenia
Schizophrenia is a severe chronic mental disease with considerable prevalence and social load. Its treatment relies on both typical and atypical antipsychotics, whose primary mechanism of action involves dopamine D2 receptor blockade, with atypical agents additionally modulating serotonergic…
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Artikel Jurnal
Yttrium-90 radioembolization as an in vivo immune modulator: clinical evidence and pharmacologic implications
Yttrium-90 (Y-90) transarterial radioembolization (TARE) is widely used for the treatment of primary and metastatic liver tumors and has traditionally been viewed as a purely locoregional radiotherapeutic modality. However, accumulating clinical evidence supports the concept that Y-90 TARE can…
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Artikel Jurnal
A retrospective clinical analysis of inappropriate Xiangdan Injection use: clinical risk profiling and computational hypothesis generation
PurposeXiangdan Injection, a traditional Chinese medicine preparation, is extensively utilized in clinical settings. Nevertheless, frequent instances of inappropriate administration pose significant safety concerns. The clinical findings were supplemented with in silico analyses (network…
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