31.912 hasil
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Artikel Jurnal
Regional absorption of talinolol mediated by intestinal transporters: insights from PBPK modeling analysis
Intestinal transporters play a pivotal role in oral absorption dynamics to shape the plasma or blood concentration-time curves of drugs, influencing interindividual pharmacokinetic (PK) variability and drug-drug or drug-food interactions. Plasma concentration-time profiles of several drugs, such as…
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Artikel Jurnal
Network pharmacology, bioinformatics and in vitro/in vivo validation elucidate the anti-lung cancer activities and potential targets of Rhoifolin
BackgroundRhoifolin (ROF), a naturally occurring flavonoid, exhibits broad bioactivities, but its therapeutic potential and underlying mechanisms in lung cancer remain largely unknown. This study was designed to systematically investigate the anti-tumor effects of ROF and identify its key molecular…
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Resveratrol reduces muscle atrophy and stress pathway activation in a combined disuse-hypoxia-mouse model
IntroductionMechanical disuse and hypoxia synergistically worsen muscle atrophy by activating apoptosis, necroptosis, and ER stress pathways. While resveratrol, a natural polyphenol, has shown protective effects in isolated disuse or hypoxia models, its efficacy under combined conditions remains…
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Artikel Jurnal
Impaired adenosine pathways in HFpEF: insights into cardiorenal alterations and endothelial responses
IntroductionHeart failure with preserved ejection fraction (HFpEF) accounts for nearly half of all heart failure cases and lacks effective therapies. Key features of HFpEF include endothelial dysfunction, fibrosis, and oxidative stress. Adenosine signaling, regulated by enzymes and receptors, is…
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Artikel Jurnal
Multitarget mechanisms of the herb pair Achyranthes bidentata and Paeonia lactiflora Pall. in ameliorating hypertensive cardiomyopathy: combining network pharmacology and functional exploration
The herb pair Achyranthes bidentata Blume and Paeonia lactiflora Pall. (AB-PL) has demonstrated significant efficacy in the treatment of hypertensive cardiomyopathy; however, its underlying mechanisms remain unclear. In this study, we established an integrated framework combining predictive network…
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Artikel Jurnal
Analysis of risk factors for herb-induced liver injury: a retrospective study from China
ObjectiveTo analyse the clinical and laboratory characteristics of patients experiencing liver injury following herbal medication use, and to identify herb-induced liver injury in patients with risk factors.MethodsThis retrospective study included patients admitted to Nanjing Hospital of Chinese…
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Artikel Jurnal
Asiaticoside promotes intestinal epithelial proliferation and barrier function in ischemia/reperfusion injury by activating FoxM1
The most important component of intestinal ischemia/reperfusion (II/R) injury is damage to the intestinal mucosal barrier. In II/R injury, damage and restoration occur simultaneously. To develop a treatment for II/R injury, further knowledge about the restoration of intestinal barrier function is…
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Artikel Jurnal
In vitro digestion and fermentation of ginseng pectic polysaccharide GPS-1 and attenuation of its product on oleic acid-induced oxidative stress in HepG2 cells
BackgroundBased on prior evidence that red ginseng pectin GPS-1 ameliorates T2DM in rats and modulates gut microbiota, we report for the first time that GPS-1 interacts with the gut microbiota of T2DM rats, as demonstrated through an in vitro digestion-fermentation model. This study reports for the…
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Artikel Jurnal
Temporal trends in stroke-prevention medication use in patients with atrial fibrillation and chronic obstructive pulmonary disease
BackgroundPatients with atrial fibrillation (AF) and concomitant chronic obstructive pulmonary disease (COPD) have been reported to exhibit a higher risk of stroke, particularly among those with a history of COPD exacerbations. However, the prescription patterns of stroke-prevention medications in…
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Global knockout of VEGFB improves lipoprotein lipase activity leading to an improved lipid profile during diabetes
Diabetes affects over half a billion people worldwide, with cardiovascular disease being its leading cause of death, either occurring secondary to atherosclerosis or due to an intrinsic defect in heart muscle (diabetic cardiomyopathy, DbCM). One instigator for DbCM is impaired cardiac metabolism…
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Artikel Jurnal
The effect of scheduled metamizole on opioid consumption after cardiac surgery
This retrospective study evaluates the impact of implementing a standardized scheduled metamizole dosing protocol within a multimodal analgesia approach after cardiac surgery. The results showed that scheduled metamizole administration was associated with lower opioid consumption, while maintaining…
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Artikel Jurnal
Zebrafish: a key model for unraveling endocrine-disrupting effects on thyroid development and function
The zebrafish (Danio rerio) has emerged as a crucial vertebrate model for studying thyroid physiology and toxicology, owing to its high genomic homology with mammals, external embryogenesis, transparent development, and the availability of advanced genetic manipulation techniques. Moreover, this…
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Artikel Jurnal
Profibrotic predictive toxicology in the lung
IntroductionFibrosis in the gossamer alveolar capillary membranes of the lung can lead to abnormalities in gas exchange, hypoxemia and death of the individual. These interstitial lung diseases (ILDs) of known or yet undefined etiologies (such as Idiopathic pulmonary fibrosis) highlight the need for…
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Artikel Jurnal
Exploring the anti-fibrotic effects of safflower in systemic sclerosis based on metabolomics and gut microbiota analyses
BackgroundSystemic sclerosis (SSc) is a complex autoimmune disease characterized by inflammation, fibrosis, and multi-organ involvement. Traditional botanical drugs have long been used empirically to manage fibrotic and inflammatory conditions, yet their pharmacological effects remain incompletely…
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Artikel Jurnal
Interplay between flaviviruses and the interferon response: mechanisms of immune evasion and therapeutic implications
The genus Orthoflavivirus encompasses a group of medically significant arthropod-borne viruses, such as dengue virus (DENV), Japanese encephalitis virus West Nile virus Zika virus (ZIKV), and others, which pose persistent global public health threats. The host interferon (IFN) system constitutes a…
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Artikel Jurnal
Modulation of tocotrienol’s bone effects by osteocytes: a perspective
Osteocytes function as central regulators of skeletal health by acting as mechanosensors that control bone remodelling mediated by osteoblasts and osteoclasts. Disrupted osteocyte function, often driven by oxidative stress and linked to ageing and osteoporosis, contributes to pathological bone…
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Artikel Jurnal
Anjiang formula inhibits PVN microglial activation and lowers blood pressure by targeting RhoA/ROCK2 pathway: a retrospective clinical and experimental study
BackgroundNeuroinflammation in the hypothalamic paraventricular nucleus (PVN) drives sympathetic overactivity in hypertension. The Anjiang Formula (AJ) shows clinical antihypertensive potential; however, the precise molecular targets mediating its central neuroprotective effects remain…
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Artikel Jurnal
Regulatory mechanisms of deer antler extracellular vesicles in multilevel tissue repair: a state-of-the-art review
Extracellular vesicles (EVs) are defined as key nanoscale messengers that mediate intercellular communication, demonstrating immense potential in tissue repair and regenerative medicine. As the only organ in mammals capable of complete, cyclical regeneration, deer antlers provide EVs with…
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