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Journal Article
Effect of compound kushen injection on immune function in patients with primary liver cancer: a systematic review and meta-analysis
BackgroundPrimary liver cancer (PLC) is the third leading cause of cancer mortality worldwide. The heterogeneity of PLC and the complex immunosuppressive microenvironment make it difficult for single treatment regimens to meet patient needs. Therefore, it is crucial to find effective combination…
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Journal Article
Rhabdomyolysis secondary to chlorpheniramine maleate toxicity: a case report
BackgroundChlorpheniramine maleate is a commonly used antiallergic drug; excessive ingestion can cause adverse effects such as hallucinations, tachycardia, central nervous system depression, and organ dysfunction. However, rhabdomyolysis induced by this drug is rarely reported. This study presents…
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Journal Article
Historical texts as a potential resource for plant-based antiviral agents against SARS-CoV-2: the example of the Receptarium of Burkhard III von Hallwyl from 16th-century Switzerland
BackgroundIn search for effective prophylactic and possibly curative therapeutics against SARS-CoV-2, an historical-ethnopharmacological approach was used to select plants described in the Receptarium of Burkhard III von Hallwyl (RBH), a recipe text from 16th century Switzerland. Ten plant species…
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Journal Article
Comprehensive dose-dependent hepatorenal protective effects of Ziziphus nummularia leaf extract against quinolphos-induced toxicity in Wistar rats
Quinolphos pose considerable hepatorenal toxicity risks, potentially necessitating the investigation of natural protective agents. This study assessed the pharmacological effects of Z. nummularia leaf extract in mitigating quinolphos-induced toxicity in male Wistar rats (n = 30) through…
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Journal Article
Progress in the research and development of oncolytic virus therapies
Oncolytic viruses (OVs) are a class of viral preparations with selective replication capability in tumor cells and the ability to activate systemic anti-tumor immunity. They have emerged as an important breakthrough in cancer treatment following chemotherapy, targeted therapy, and immune checkpoint…
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Journal Article
Neurocysticercosis in transition: expanding clinical spectrum, evolving diagnostics, and emerging therapies
Neurocysticercosis (NCC) infection of the central nervous system by Taenia solium larvae, remains a leading cause of acquired epilepsy in endemic regions and an increasingly recognized imported disease elsewhere. The traditional view of NCC as a solitary parenchymal cyst causing seizures has…
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Journal Article
Efficacy and safety of camrelizumab-based regimens in advanced squamous cell carcinoma patients: a prospective multicenter study
ObjectiveCamrelizumab-based regimens show promising efficacy in esophageal cancer patients, according to previous pivotal trials. Given the strict eligibility criteria in pivotal trials, real-world studies are essential to evaluate the efficacy and safety of camrelizumab-based regimens in a broader…
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Journal Article
Pharmacological potential of Chinese botanical drugs in managing chronic kidney disease by targeting mitochondrial quality control
Chronic kidney disease (CKD) is a multifactorial health issue characterized by structural and functional impairments of the kidneys, with significant incidence and mortality rates in global populations. Mitochondrial quality control (MQC) comprises cellular mechanisms that maintain mitochondrial…
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Journal Article
The mechanism of Vicenin-2 in ameliorating skin photoaging: involvement of m6A-modified macrophage polarization
BackgroundSkin photoaging is primarily induced by ultraviolet radiation and is closely associated with chronic inflammation and degradation of the extracellular matrix, with an imbalance in macrophage polarization (elevated M1/M2 ratio) being a key factor.MethodsThis study first conducted…
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Journal Article
Effects of sleeve gastrectomy on rivaroxaban pharmacokinetics, efficacy, and safety
BackgroundThromboembolic events are potentially serious complications in patients undergoing bariatric surgery. Several studies have investigated the use of rivaroxaban in patients undergoing bariatric surgery. Further evidence is required to determine whether postsurgical anatomical and…
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Journal Article
Eliglustat prevents acute kidney injury caused by Shiga toxin 2 in lethal and sublethal rat models of hemolytic uremic syndrome
BackgroundShiga toxin-producing Escherichia coli is the main cause of post-diarrheal hemolytic uremic syndrome (HUS), which produces acute kidney injury mainly in children. Shiga toxin exerts its action by binding to the glycolipid globotriaosylceramide (Gb3) on the cell surface of target tissues…
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Journal Article
Signaling network inhibition by selected traditional Chinese medicine preparations: a novel multi-target paradigm for colorectal cancer therapy
Colorectal cancer (CRC) remains a significant global health burden, with drug resistance, recurrence, and metastasis posing major therapeutic challenges. Traditional Chinese Medicine (TCM), employing a holistic “multi-component, multi-target, multi-pathway” strategy, offers a promising…
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Journal Article
Changes in youth public psychiatric service utilization during the COVID-19 pandemic in Italy: an observational study
IntroductionSocial restrictions due to the COVID-19 pandemic have impacted the lives of children and adolescents worldwide. In this study, we aim to evaluate the impact of lockdown periods implemented in Italy during the SARS-CoV-2 waves on the mental health of minors.MethodsA population-based…
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Journal Article
DPYD genotyping in patients receiving capecitabine: an exploratory analysis from the D-TORCH study
Introduction: Deficiency of the dihydropyrimidine dehydrogenase enzyme can result in capecitabine-related toxicity due to genetic alterations in the DPYD gene, leading to complete or partial DPD deficiency and poor or intermediate metabolizer phenotypes. The distribution of DPYD variants varies…
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Journal Article
Thalamic distribution and effects of 5-HT2C receptors on tonic GABAA inhibition and absence seizures: implications for treatment
IntroductionChildhood absence epilepsy (CAE) is associated with abnormal thalamocortical oscillations and enhanced GABAergic function in the ventrobasal (VB) thalamus, including increased extrasynaptic GABAA receptor–mediated tonic currents in thalamocortical (TC) neurons. Serotonin signaling…
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Journal Article
A highly specific fluorescent probe with facile pretreatment for rapid and accurate detection of sulfur dioxide residues in wolfberry (Lycium barbarum L.)
IntroductionSulfur fumigation is a traditional technique for drying, pest control and mildew prevention in traditional Chinese medicine (TCM). However, excessive sulfur fumigation significantly impairs drug safety and clinical efficacy, rendering sulfur dioxide (SO2) residues in sulfur-fumigated…
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Journal Article
Aspirin use and risk of depression: a cross-sectional study
BackgroundThe association between aspirin use and depression risk remains controversial.MethodsBased on the National Health and Nutrition Examination Survey (NHANES) database from the 2011 to 2018, a cross-sectional study was designed. Depression was estimated using Patient Health Questionnaire-9…
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Journal Article
QT-related adverse events with ondansetron and olanzapine: a real-world FAERS analysis with implications for oncology anti-emetic practice
PurposeQT prolongation remains an important safety concern for antiemetic regimens, especially in oncology where polypharmacy and metabolic stress often intersect. Ondansetron and olanzapine are now used side by side in many chemotherapy and perioperative settings, yet their comparative real-world…
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Journal Article
Therapeutic relevance of an EU-GMP certified Cannabis sativa L. strain in a dual in vivo model of cognitive impairment and chronic neuropathic pain
BackgroundAlzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and frequently co-occurs with chronic pain. Worldwide, over 55 million people are affected by AD, with nearly half experiencing persistent pain. Chronic pain has been linked to…
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Journal Article
Globulol from Alpinia oxyphylla Miq. Enhances the pharmacological effects of anti-PD-1 drugs in combination by reducing PD-L1 expression in hepatocellular carcinoma
IntroductionGlobulol is a terpenoid metabolite isolated from Alpinia oxyphylla Miq. Previous studies have demonstrated that terpenoid metabolites exhibit anti-inflammatory, antioxidant, and antitumor activities. However, the exact mechanisms by which Globulol impacts HCC remain obscure.Materials…
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