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Artikel Jurnal
Functional-genomic prioritization identifies MED12 as a candidate RNAi vulnerability in acute myeloid leukemia: evaluation of a T22 peptide-functionalized LNP-siRNA formulation
BackgroundAcute myeloid leukemia (AML) depends in part on transcriptional and epigenetic programs that can be difficult to target with conventional small molecules. RNA interference provides a potential approach to perturb such vulnerabilities, but target selection and intracellular siRNA delivery…
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Artikel Jurnal
Comparative hepatic safety between tegoprazan and esomeprazole: a real-world cohort study
IntroductionTegoprazan is a newer P-CAB with favorable tolerability, yet data on hepatic safety remain limited. We compared the incidence of laboratory-defined hepatic events between tegoprazan and esomeprazole, a PPI with a well-established safety profile.MethodsWe conducted a retrospective…
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Artikel Jurnal
Optimal prophylaxis for perioperative drug-induced delayed neurocognitive recovery: a Bayesian network meta-analysis of 18 interventions with mechanism-based stratification
BackgroundPostoperative delayed neurocognitive recovery (dNCR) is a common and serious perioperative complication. Although there are various drugs available for prevention, there is a lack of efficacy comparison and significant controversy exists.MethodsSystematic searches were conducted in…
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Artikel Jurnal
Circulating serotonin is associated with calcific aortic valve stenosis: a two-phase metabolomics study
BackgroundCalcific aortic valve stenosis (CAVS) is the most prevalent valvular heart disease in the elderly, yet no pharmacological therapy can halt its progression, partly due to incomplete understanding of disease-associated metabolic alterations and the lack of circulating biomarkers for disease…
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Artikel Jurnal
Protectin DX alleviates lumbar radicular pain in rats by suppressing RIP3/MLKL-associated necroinflammation through restoration of autophagic function
BackgroundLumbar radicular pain (LRP) is a prevalent neuropathic pain disorder driven by nucleus pulposus (NP)-induced inflammation. Protectin DX (PDX), a novel specialized pro-resolving lipid mediator (SPM), exerts pro-resolving and analgesic effects in LRP. However, the underlying molecular…
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Artikel Jurnal
Regulation on the metabolic synaptic pathway in the dorsal raphe nucleus in a rat model chronic olanzapine-induced body weight gain
ObjectiveTo explore the proteomic difference and mechanism in the dorsal raphe nucleus (DRN) of rats with body weight gain induced by long-term olanzapine administration.MethodsThirty-six female Sprague-Dawley rats were randomly divided into two groups: an olanzapine treatment group (2.4 mg/(kg·d)…
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Artikel Jurnal
Incidence, burden, and associated factors of severe potential drug–drug interactions in intensive care unit patients: a real-world retrospective study
IntroductionSevere potential drug-drug interactions (pDDIs) in intensive care unit (ICU) patients remain insufficiently characterized. This study investigated the incidence, patterns, burden, and associated factors of severe pDDIs.MethodsThis single-center retrospective cohort included ICU…
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Artikel Jurnal
Efficacy and safety of Compound Danshen Dripping Pills as an adjunct to conventional therapy for stable angina pectoris: an updated systematic review and meta-analysis of randomized controlled trials
ObjectiveTo systematically evaluate the efficacy and safety of Compound Danshen Dripping Pills (CDP) in the treatment of stable angina pectoris (SAP) and provide updated evidence regarding its clinical application.MethodsA comprehensive literature search was conducted in eight electronic databases…
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Artikel Jurnal
Detection of adverse event signals associated with key immunosuppressants for autoimmune hepatitis: insights from the food and drug administration adverse event reporting system database
BackgroundAutoimmune hepatitis (AIH) requires long-term immunosuppressive therapy, yet the comparative safety profiles of key drugs remain incompletely characterized. The objective of this study was to conduct a systematic evaluation of the adverse drug event (ADE) signals associated with…
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Artikel Jurnal
Targeting the AcrAB-TolC efflux pump by small molecules selectively addressing the outer membrane factor TolC
BackgroundGram-negative bacteria express several efflux pump complexes extruding a broad spectrum of antibiotics. The major efflux pump in E. coli is the AcrAB-TolC complex that expels a broad spectrum of antibiotics from the bacterium, resulting in impaired efficacy of these drugs. Therefore, the…
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Artikel Jurnal
Hepatoprotective action of Dendrobium officinale polysaccharide against MAFLD: modulation of gut microbiota-metabolite cascade controls TLR4/NF-κB inflammatory response
IntroductionMetabolic dysfunction-associated fatty liver disease (MAFLD) threatens public health worldwide, and Dendrobium officinale polysaccharide (DOP) exhibits promising hepatoprotective potential, yet its regulatory mechanism targeting the gut microbiota-metabolite-TLR4/NF-κB inflammatory axis…
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Artikel Jurnal
N-salicyloyl tryptamine derivatives as potential therapeutic agents for doxorubicin-induced hepatotoxicity via PI3K/AKT/HO-1 signaling pathway
Doxorubicin (DOX) is a broad-spectrum antineoplastic agent with remarkable efficacy against various malignant tumors. However, its clinical application is severely limited by profound hepatotoxicity, wherein oxidative stress acts as a pivotal mechanism underlying DOX-induced hepatotoxicity…
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Artikel Jurnal
Research landscape and emerging themes of ferroptosis in sepsis-associated acute kidney injury: a bibliometric and science-mapping analysis (2016–2025)
BackgroundFerroptosis has received increasing attention as a regulated cell-death process potentially involved in sepsis-associated acute kidney injury (SA-AKI). However, the structure, development, and thematic evolution of the SA-AKI–ferroptosis literature have not been clearly characterized…
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Artikel Jurnal
A retrospective analysis of adverse drug reaction case reports for PARP inhibitors: a comparative study of olaparib and niraparib
BackgroundOlaparib and niraparib are the most widely used poly (ADP-ribose) polymerase inhibitors (PARPis) in clinical practice. However, clinical trial data inadequately capture rare and delayed adverse drug reactions (ADRs) in real-world settings, and a systematic comparison of their ADR profiles…
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Artikel Jurnal
Omalizumab for pediatric allergic asthma: evidence-based insights on efficacy and safety from a meta-analysis of randomized trials
ObjectivesThis meta-analysis aimed to synthesize data from English-language randomized controlled trials (RCTs) to evaluate the efficacy and safety of omalizumab in patients aged 6–20 years with allergic asthma, with specific attention to age-stratified outcomes where feasible.MethodsConducted in…
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Artikel Jurnal
Treatment effects and safety of Chinese herbal medicine in gastroesophageal reflux disease: a systematic review of randomized controlled trials and a network meta-analysis with component analysis
BackgroundGastroesophageal reflux disease (GERD) is commonly treated with proton pump inhibitors (PPIs) despite their adverse effects and risk of recurrence. Chinese herbal medicine (CHM) has long been used to alleviate reflux-related symptoms and reduce relapse through multi-component and…
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Artikel Jurnal
Benzyl isothiocyanate alleviates neural damage in experimental autoimmune uveitis by modulating the TREM-1/PI3K/AKT signaling pathway
Purpose: To investigate whether Benzyl isothiocyanate (BITC) can improve experimental autoimmune uveitis (EAU) and explore its potential mechanism. Methods: To evaluate the therapeutic efficacy of BITC, EAU was induced in C57BL/6 mice via immunization with IRBP651-670. Clinical scores and…
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Artikel Jurnal
Case Report: Treatment of fulminant paraquat poisoning in a 32-week pregnant patient: a case report exploring the potential role of estrogen
Paraquat (PQ) poisoning is a life-threatening condition characterized by severe toxicity and the absence of a specific antidote. Prognosis is strongly correlated with the ingested dose, with high-dose exposure frequently resulting in multi-organ failure and fatal outcomes. This case report presents…
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Artikel Jurnal
Disproportionality analysis of adverse event signals associated with seven Alzheimer’s drugs: insights from the FAERS database
ObjectiveTo compare adverse event reporting patterns for seven Alzheimer’s disease (AD) drugs (aducanumab, donanemab, lecanemab, donepezil, galantamine, rivastigmine, and memantine) using the FDA Adverse Event Reporting System (FAERS), and to explore potential reporting signals.MethodsFAERS reports…
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