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Artikel Jurnal
Integrated network toxicology and multi-omics profiling reveal cell cycle, DNA damage repair, and metabolic alterations in cyclophosphamide-induced premature ovarian insufficiency
BackgroundCyclophosphamide (CTX)-induced chemotherapy injury is a leading iatrogenic cause of premature ovarian insufficiency (POI) and a major barrier to fertility preservation. Yet the systems-level mechanisms underlying its reproductive toxicity remain poorly defined.MethodsAn integrated network…
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Artikel Jurnal
Toxicoproteomics of APAP-exposed HepG2 cells identifies candidate translational biomarkers of liver injury and recovery
IntroductionDrug‐induced liver injury (DILI) is a leading cause of acute liver failure (ALF) and a major obstacle in drug development, reflecting the lack of robust, mechanism‐based biomarkers. Human in vitro systems, coupled with unbiased omics, provide controlled, human‐relevant and…
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Artikel Jurnal
Tirzepatide versus other anti-diabetic agents for the prevention of diabetic foot complications in patients with type 2 diabetes
BackgroundDiabetic foot complications affect up to 25% of patients with type 2 diabetes (T2D) and represent a major cause of morbidity. The dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist - tirzepatide (TZP) has demonstrated superior glycemic control…
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Artikel Jurnal
Exposure-driven tolerance modeling of efpeglenatide-induced nausea or vomiting using repeated time-to-event analysis: implications for dose-escalation strategies
IntroductionNausea or vomiting are common adverse events (AEs) associated with glucagon-like peptide-1 receptor agonists and often decline over time despite continued exposure, suggesting tolerance development. However, the longitudinal dynamics of recurrent events and tolerance have not been…
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Artikel Jurnal
Acute psilocybin or ethocybin leads to a sustained increase in Pavlovian aversion memory in male mice
There is considerable interest in the concept that psychedelic compounds might facilitate reorganization of emotional processing with therapeutic benefit; in particular, amelioration of excessive focus on past, current and potential-future aversive events, a dominant emotional-cognitive state in…
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Artikel Jurnal
Pasteurized Akkermansia muciniphila as a candidate multi-effector pharmacological system in the gut-liver axis: evidence, unresolved causality, and translational priorities
Pasteurized Akkermansia muciniphila is a clinically tractable postbiotic candidate, but its activity cannot be assigned to a single principle. Heat-stable Amuc_1100 is demonstrably retained in pasteurized cells, whereas the GLP-1-inducing protein P9, extracellular vesicles (AmEVs), membrane lipids…
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Artikel Jurnal
Host-directed therapeutics against antimicrobial-resistant bacterial infections: emerging roles of multi-omics and systems biology
The rapid emergence and global dissemination of antimicrobial resistance (AMR), coupled with the limited development of new antimicrobial agents, have intensified concerns regarding a major global public health crisis. Although antibiotic resistance is primarily driven by microbial mechanisms, host…
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Artikel Jurnal
Smart nanodelivery systems targeting tumor-associated macrophage reprogramming to potentiate cancer immunotherapy: pharmacological mechanisms, delivery strategies and translational perspectives
Cancer immunotherapy, particularly immune checkpoint blockade, has substantially changed the treatment landscape for multiple malignancies, but clinical benefit remains limited by low response rates, primary tolerance, and acquired resistance. Tumor-associated macrophages (TAMs) are abundant and…
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Artikel Jurnal
Cenobamate in Dravet syndrome with electrophysiologically confirmed SCN1A loss-of-function variants: long-term real-world follow-up
Dravet syndrome (DS) is a severe developmental and epileptic encephalopathy (DEE) characterized by seizures and developmental delay/regression, primarily caused by loss-of-function (LoF) variants in the SCN1A gene, which encodes the Nav1.1 sodium channel. Hyperexcitability in DS results from…
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Artikel Jurnal
Targeting UAP1 with rabeprazole: a novel repurposed therapeutic strategy for multiple myeloma
BackgroundDespite significant advancements in proteasome inhibitors and immunomodulatory drugs, multiple myeloma (MM) remains largely incurable due to persistent drug resistance and frequent relapse, highlighting an urgent need for novel therapeutic targets.MethodsWe analyzed Multiple Myeloma…
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Artikel Jurnal
Efficacy and safety of ropeginterferon in myeloproliferative neoplasms: a systematic review and meta-analysis
BackgroundRopeginterferon alfa-2b (ropegIFN-α2b or ropeginterferon) has emerged as a therapeutic option for patients with myeloproliferative neoplasms, particularly polycythemia vera (PV), with potential disease-modifying effects. This systematic review aimed to evaluate the efficacy and safety of…
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Artikel Jurnal
Effects of andrographolide on cellular metabolism and mitochondrial function: current evidence and insights into its anticancer mechanisms
Andrographolide, a labdane diterpenoid derived from Andrographis paniculata, has demonstrated anticancer activity across multiple preclinical models. Accumulating evidence indicates that andrographolide acts as a multitarget modulator of signaling and metabolic pathways, including PI3K/Akt, MAPK…
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Artikel Jurnal
Research progress in clinical utilization of H2 as a pleiotropic agent
H2 is a fundamental environmental factor for the origin of life, providing an energetic basis for the emergence of primitive life. Through its selective antioxidant, anti-inflammatory, and anti-apoptotic activities, as well as its regulatory effects on cell signaling pathways and gene expression…
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Artikel Jurnal
Depleted before the dose: the mitochondrial vulnerability threshold hypothesis for fluoroquinolone-associated multisystem toxicity
Fluoroquinolone (FQ) antibiotics have an established capacity for mitochondrial injury, yet only a subset of exposed patients develop severe or persistent toxicity. We propose the Mitochondrial Vulnerability Threshold (MVT) hypothesis: that whether a standard therapeutic FQ dose produces clinically…
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Artikel Jurnal
Carnosic acid alleviates high-altitude cerebral edema by suppressing oxidative stress and microglia activation-induced neuroinflammation
BackgroundOxidative stress and neuroinflammation constitute key pathological contributors to high-altitude cerebral edema (HACE). Carnosic acid (CA) exerts important roles in neurodegeneration and brain injury, but its function in HACE remains elusive.MethodsHigh-altitude hypobaric hypoxic…
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Artikel Jurnal
Biologic therapy for Crohn’s disease (2015–2025): a bibliometric analysis of global research trends and current status
BackgroundCrohn’s disease (CD) is a chronic inflammatory bowel disease with rising global prevalence. Biologic agents have become the cornerstone of treatment for moderate-to-severe CD, yet the rapidly expanding literature makes systematic tracking of research trends challenging. This study…
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