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Artikel Jurnal
Postmarketing reporting patterns of Candida-related events associated with bimekizumab and selective IL-17A inhibitors in psoriasis: a FAERS and JADER pharmacovigilance study
BackgroundCandida-related events are established labelled events during IL-17 pathway inhibition. The remaining pharmacovigilance question is how Candida phenotypes are represented in spontaneous reports for bimekizumab and selective IL-17A inhibitors within psoriasis, while accounting for the…
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Artikel Jurnal
Needle extracts of Pinus squamata X.W. Li ameliorate obesity and modulate cecal microbiota in high-fat diet-induced obese mice
Obesity is closely associated with excessive adipose accumulation, chronic low-grade inflammation, and gut microbiota dysbiosis. Although needle extracts from several Pinus species have been reported to attenuate body weight gain and modulate the gut microbiota, the pharmacological properties of…
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Artikel Jurnal
Neuroprotective effects and mechanistic insights of sinomenine in ischemic stroke: a systematic review and meta-analysis of preclinical animal studies
BackgroundIschemic stroke is a leading cause of long-term disability and mortality worldwide. Despite substantial advances in reperfusion therapy, effective neuroprotective strategies remain limited. Sinomenine, a bioactive alkaloid derived from plants of the Menispermaceae family, has shown…
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Artikel Jurnal
Sacituzumab govitecan combined with anlotinib in metastatic triple negative breast cancer patient with repeated pleural effusion: a case report
Metastatic triple-negative breast cancer (mTNBC) is an aggressive malignancy with limited targeted therapeutic alternatives and dismal long-term prognosis. Sacituzumab govitecan (SG) is a Trop-2-directed antibody-drug conjugate (ADC) conjugated to the topoisomerase I inhibitor SN-38. SG has…
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Artikel Jurnal
Kaempferol in inflammatory bowel disease: regulating intestinal epithelial-fibroblast crosstalk
IntroductionInflammatory bowel disease (IBD) has an intricate pathophysiology that greatly impacts patients’ quality of life. Wumei Wan, a traditional Chinese medicinal formulation, exhibits specific therapeutic effects on IBD. Kaempferol (KF), an active ingredient in Wumei Wan, may significantly…
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Artikel Jurnal
From molecular correction to functional rescue: delivery, tissue state, and immunobiology as the principal constraints on dystrophin-restoring therapy in Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) arises from thousands of distinct mutations at a single X-linked locus that converge on loss of functional dystrophin, and this convergence on one molecular endpoint—rather than any genetic uniformity—has long made the disease appear a candidate for straightforward…
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Artikel Jurnal
Codonopsis pilosula inulin-type fructan CPA ameliorates diarrhea-predominant irritable bowel syndrome via regulation of ER stress-induced autophagy and modulation of gut microbiota
Diarrhea-predominant irritable bowel syndrome (IBS-D) is characterized by diarrhea, abdominal pain, and recurrent symptoms, posing significant clinical challenges. This study utilized the GSE36701 dataset from the Gene Expression Omnibus (GEO) and applied weighted gene co-expression network…
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Artikel Jurnal
A preliminary study of a machine-learning prediction model for lung cancer diagnosis based on routine blood indicators and traditional chinese medicine diagnostic parameters
BackgroundEarly identification of lung cancer remains challenging in clinical practice, especially in patients who cannot undergo advanced imaging or invasive examinations. Traditional Chinese Medicine (TCM) provides distinctive diagnostic insights, but the potential role of its objective features…
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Artikel Jurnal
Angiogenesis inhibitors and the risk of peripheral artery aneurysm and dissection: a cross-database study
BackgroundAnti-angiogenic inhibitors (AI) have transformed cancer treatment but are associated with vascular toxicities. The specific association with peripheral artery aneurysm and dissection (PAAD) remains uncharacterized. This study aimed to evaluate the association between AI exposure and PAAD…
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Artikel Jurnal
Immune checkpoint inhibitor-related myotoxicity in lung cancer: a decade-long real-world pharmacovigilance analysis of the FAERS database
BackgroundImmune checkpoint inhibitor therapy has revolutionized the treatment of several malignancies, with improved survival, yet the accompanying myotoxicity has often been underestimated. We aimed to comprehensively and comparatively analyze the risk of myotoxicity associated with various ICIs…
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Artikel Jurnal
Ulcerative colitis therapeutic effects and pharmacokinetics of flexible quercetin nanocrystals prepared with geniposide assistance
ObjectiveThis study aimed to improve the oral bioavailability and therapeutic efficacy of quercetin (QUE) against ulcerative colitis (UC) by formulating flexible quercetin nanocrystals (QUE-NCs) with the assistance of geniposide (Gen).MethodsQUE-NCs were prepared via an antisolvent precipitation…
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Artikel Jurnal
Structure-based virtual screening identifies ethyl rosmarinate as a SLC1A6-targeted therapeutic candidate for bladder cancer
ObjectiveSLC1A6 remains poorly characterized in bladder cancer. This study investigated its expression pattern, clinical relevance, cellular localization, functional implications, and potential pharmacological modulation.MethodsBulk transcriptomic cohorts, clinical data, single-cell RNA-seq data…
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Artikel Jurnal
Systems-level analysis uncovers eight hub genes and a resveratrol-based therapeutic strategy for ischemic stroke
Ischemic stroke is a leading cause of mortality and long-term disability worldwide, yet its underlying molecular mechanisms remain incompletely understood. The pathology involves complex interactions between vascular injury, immune dysregulation, metabolic imbalance, and mitochondrial dysfunction…
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Artikel Jurnal
Mesenchymal stem cells: a potential therapeutic strategy for IgA nephropathy
IgA nephropathy (IgAN) is the predominant primary glomerulonephritis worldwide, characterized by the deposition of IgA-containing immune complexes in the glomerular mesangium. Despite advances in supportive care, there is a lack of IgAN-specific therapies capable of halting IgAN progression…
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Artikel Jurnal
Gut dysbiosis in difficult-to-treat rheumatoid arthritis: hypothesized microbial endotypes, persistent inflammation, and pharmacological treatment resistance
Difficult-to-treat rheumatoid arthritis (D2T RA) remains a major clinical problem despite treat-to-target care and an expanding range of disease-modifying antirheumatic drugs (DMARDs). D2T RA includes biologically distinct states, particularly persistent inflammatory refractory rheumatoid arthritis…
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Artikel Jurnal
A pharmacist-led framework for antibiotic-associated liver injury: from pharmacovigilance signals to bedside surveillance with the updated RUCAM and susceptibility markers
Antibiotics account for more cases of idiosyncratic drug-induced liver injury (DILI) than any other drug class. At the bedside, attributing injury to a particular antibiotic is difficult: there is no confirmatory test, and latency and biochemical pattern vary markedly among agents…
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Recent advances in research on novel therapeutic mechanisms and strategies for exosome-based treatment of ischemic stroke
Ischemic stroke (IS) accounts for over 80% of all stroke cases, featuring high disability, mortality, and recurrence rates. Conventional intravenous thrombolysis and mechanical thrombectomy are limited by narrow therapeutic windows, reperfusion injury, and the blood–brain barrier (BBB), which…
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Artikel Jurnal
Chinese botanical drugs for mitigating epidermal growth factor receptor-targeted therapy-associated cutaneous toxicity: immune mechanisms and translational pathways
BackgroundTherapies targeting the epidermal growth factor receptor (EGFR) cause a spectrum of cutaneous toxicities that can compromise quality of life, treatment adherence, and cancer-treatment continuity. Persistent and phenotype-specific toxicities create a need for evidence-based adjunctive…
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Artikel Jurnal
From time-series deep learning to physics-constrained population pharmacokinetics: AI-driven prediction of drug concentrations and exposure for model-informed dosing
Therapeutic drug monitoring (TDM) starts from a single measured concentration, which population pharmacokinetics (PopPK) with Bayesian maximum a posteriori (MAPB) estimation converts into a revised dose. Since roughly 2021, two research lines have been converging. Time-series deep learning models…
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Artikel Jurnal
Traditional Chinese medicine in non-muscle-invasive bladder cancer: a scoping review of syndrome characteristics and critical synthesis of pharmacological and mechanistic evidence
Non-muscle-invasive bladder cancer (NMIBC) is characterized by frequent recurrence and prolonged surveillance. Traditional Chinese medicine (TCM) has been investigated as an adjunct to standard NMIBC management, but its syndrome characteristics and pharmacological evidence remain heterogeneous…
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