31,912 results
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Journal Article
Multi-target neuroprotective mechanisms of epigallocatechin-3-gallate (EGCG) in stroke: from molecular pathways to nanomedicine delivery and clinical translation
Stroke ranks among the leading global causes of mortality and permanent disability. Its secondary brain injury arises from multiple interrelated pathological cascades, including oxidative stress, neuroinflammation, disrupted autophagy-apoptosis balance, excitotoxicity, iron dyshomeostasis, and…
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Journal Article
Anisodamine hydrobromide reduces 28-day mortality in septic shock: a randomized controlled
BackgroundThis randomized controlled trial evaluated whether anisodamine hydrobromide reduces 28-day mortality in septic shock and whether this effect is mediated by lactate and lactate clearance.MethodsIn this prospective randomized controlled trial, 296 patients with septic shock were randomly…
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Journal Article
Association between post procedural parenteral anticoagulation therapy and clinical outcomes in ST-elevation myocardial infarction patients with high thrombotic risk
BackgroundCurrent guidelines advise against routine use of parenteral anticoagulation therapy (PACT) for ST-segment elevated myocardial infarction (STEMI) patients after percutaneous coronary intervention (PCI). However, the effectiveness of PACT in such patients with high thrombotic risk remains…
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Journal Article
Bioactive compounds from Tetradenia riparia and Tetracera poggei: antioxidant activity, UPLC-QTOF-MS phytochemical profiling, and in silico targeting of the RNA-binding protein DRBD18 of Trypanosoma brucei
Oxidative stress has been implicated in the pathogenesis of African trypanosomiasis. Therefore, plant-derived antioxidants have been investigated as potential therapeutic agents, as they may not only reduce oxidative damage by scavenging reactive oxygen species but also impair parasite survival…
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Journal Article
Differential functions of ROCK1 and ROCK2 in liver fibrosis and advances in targeted therapeutic strategies
Liver fibrosis, driven by metabolic dysfunction-associated steatohepatitis (MASH) and other chronic injuries, represents a global health crisis without approved pharmacological therapies. The Rho-associated coiled-coil kinases (ROCK1 and ROCK2), the principal effectors of Rho GTPases, have emerged…
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Journal Article
Efficacy of plant extracts for metabolic dysfunction-associated steatotic liver disease: a network meta-analysis
BackgroundMetabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of chronic liver disease worldwide, affecting approximately 38% of the global population. This network meta-analysis systematically compared the effects of different plant extracts on liver biochemical and…
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Journal Article
Safety signals and CMV-related events reported during letermovir therapy: a FAERS database study
BackgroundLetermovir is an antiviral agent approved for CMV infection prophylaxis in transplant recipients. This study aimed to evaluate safety signals reported during letermovir treatment, using data from the FDA Adverse Event Reporting System (FAERS).MethodsData from October 2017 to September…
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Journal Article
Knowledge graph and machine learning-guided virtual screening prioritizes putative blockers of the PSMD11/Rpn6-EBOV glycoprotein interface
IntroductionHost-directed antiviral discovery requires a traceable route from host-factor identification to testable molecular hypotheses. This study developed such a workflow around a host factor associated with Ebola virus glycoprotein (EBOV GP).MethodsGFP-GP pulldown coupled with…
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Journal Article
Efficacy and safety of P2X3 receptor antagonists in refractory or unexplained chronic cough: an updated systematic review and meta-analysis
BackgroundRefractory chronic cough and unexplained chronic cough are increasingly understood as clinical expressions of cough hypersensitivity. P2X3 receptor antagonists have been developed to reduce ATP-mediated airway sensory nerve activation, but their benefit must be balanced against…
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Journal Article
Intranasal hydrogels for Alzheimer’s disease: from nasal-interface engineering to brain targeting and translational readiness
Intranasal hydrogels offer a strategy to address rapid mucociliary clearance, limited nasal residence, difficult payload properties, and insufficient brain exposure in Alzheimer’s disease (AD). This Review evaluates hydrogel and hydrogel-associated systems across formulation architecture…
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Journal Article
Case report: Butylphthalide-associated severe thrombocytopenia, a rare adverse drug reaction
IntroductionButylphthalide (DL-NBP) is a widely used neuroprotective agent for acute ischemic stroke. Although generally well-tolerated, severe thrombocytopenia as a rare adverse reaction has not been fully recognized. Herein, we report a severe case of probable DL-NBP-associated thrombocytopenia…
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Journal Article
Plant-derived modulators of the hemostasis-wound healing axis: mechanisms, evidence, and translational potential
Medicinal plants are widely used to control bleeding and support wound care, but the hemostatic and reparative evidence attributed to a species often derives from different plant parts, extracts, or formulations. This critical narrative review examines the ethnomedicinal, experimental, clinical…
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Journal Article
Advances in androgenetic alopecia model research
Androgenetic alopecia (AGA) is the most prevalent form of non-scarring hair loss, and its pathogenesis is quite complex, involving androgen metabolism, follicular microenvironment imbalance, oxidative stress, and inflammatory responses. Understanding these multifactorial mechanisms is critical for…
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Journal Article
A review of protective effects of Withania somnifera and its bioactive component withaferin A in organ ischemia-reperfusion injury
Withania somnifera (WS) is an Ayurvedic botanical which has been extensively studied for thousands of years. Withanolides are the main pharmacologically active ingredients isolated from WS and withaferin A (WA) is the most extensively studied and therapeutically effective withanolide compound. WS…
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Journal Article
Targeting the NLRP3 inflammasome in rheumatoid arthritis fibroblast-like synoviocytes: pathogenic mechanisms, therapeutic strategies, and translational perspectives
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by persistent synovitis, pannus formation, cartilage degradation, and bone erosion. Although conventional synthetic, biologic, and targeted synthetic disease-modifying antirheumatic drugs have improved disease control…
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Journal Article
Circular RNAs in cancer: from biomarkers to vaccine-based immunotherapy
Circular RNAs (circRNAs) are endogenous, covalently closed RNA molecules generated through back-splicing that exhibit exceptional stability, evolutionary conservation, tissue-specific expression and diverse regulatory functions. Compared with conventional RNA-based therapeutic platforms, such as…
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Journal Article
AI-driven multi-omics biomarkers in precision breast cancer therapeutics: from discovery to clinical translation
Breast cancer is biologically heterogeneous, yet conventional clinical decisions rely on static, single-marker proxies (ER, PR, HER2, and Ki-67) that capture only a narrow slice of tumor biology. This mini-review argues that AI-driven multi-omics biomarkers offer a valuable shift toward…
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Journal Article
The role of sitagliptin in modifying metabolic, hormonal and clinical parameters in polycystic ovarian syndrome patients: a randomized controlled trial
BackgroundPolycystic ovarian syndrome (PCOS) is a disease that is not limited to reproductive symptoms; it is also significantly linked to metabolic problems such as obesity, insulin resistance, and dyslipidemia. Sitagliptin, a DPP-4 inhibitor, may play a significant role in metabolic…
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