31,912 results
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Journal Article
Pimpinella brachycarpa extract attenuates periodontal inflammation by modulating the PI3K/Akt–NF-κB signaling pathway
IntroductionThis study was conducted to investigate the preventive effects of Pimpinella brachycarpa extract (PBE), which has demonstrated anti-inflammatory effects but whose molecular mechanisms and active components are not completely understood, in experimental periodontitis and to elucidate its…
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Journal Article
Development and validation of machine learning models for predicting pancreatic injury observed after tigecycline initiation: a retrospective real-world study
BackgroundTigecycline is widely used for severe infections and infections caused by multidrug-resistant pathogens. Although pancreatic injury observed after tigecycline initiation is relatively uncommon, it may adversely affect patient prognosis. Currently, clinical management mainly relies on…
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Journal Article
Comparative performance of multiple predictive models constructed for budesonide nebulized formulation requirements
BackgroundDeveloping rational demand forecasting plans for National Centralized Volume-Based Procurement (NCVBP) pharmaceuticals is critical to ensuring patient access while avoiding drug inventory surplus, thereby facilitating refined hospital management and reducing operational costs. This study…
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Journal Article
Personalized Boolean network dynamic profiling and machine learning approaches to identify combinatorial treatments for prostate cancer
IntroductionProstate cancer is the most commonly diagnosed non-cutaneous cancer in males and the second leading cause of male cancer death in the United States. Androgen deprivation therapy to block androgen receptor (AR) signaling is part of the standard of care. However, approximately 30%–40% of…
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Journal Article
Zhuyu pill relieves cholestasis in rats by modulating the expression of lncRNAs and circRNAs
BackgroundZhuyu pill (ZYP), a traditional Chinese medicine (TCM) formula composed of Coptis chinensis Franch and Tetradium ruticarpum (A. Jussieu) T. G. Hartley, exhibiting potential anti-cholestatic effects. However, its specific mechanism remains unclear. Long noncoding RNAs (lncRNAs) and…
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Journal Article
Tumor-on-chip and cancer microphysiological platforms: knowledge structure, thematic evolution, and the emergence of organoid-integrated models, 2010–2025
BackgroundCancer microphysiological systems (MPS), including tumor-on-chip platforms, combine engineered microenvironments, controlled fluid transport, and tumor-relevant biological models for cancer modeling, drug testing, and translational research. Organoid-integrated chips represent one…
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Journal Article
Statistical process control within the Six Sigma DMAIC framework for monitoring medication dispensing errors in hospital pharmacies: a Saudi case study
This study employed the Six Sigma DMAIC methodology to monitor and analyze medication dispensing errors in hospital pharmacies in Saudi Arabia, with a focus on Mecca and Jeddah cities. Using aggregated data from the Ministry of Health (MOH) Statistical Yearbook 2024, a synthetic dataset was…
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Journal Article
MolecureAI: an agentic AI platform for autonomous drug discovery
Accelerating the identification of viable drug candidates across therapeutic areas demands autonomous systems for molecular generation that enforce chemical correctness by structural invariants rather than model capability. We present MolecureAI, an autonomous AI agent architecture for closed-loop…
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Journal Article
Gastrodin alleviates mild cognitive impairment and Alzheimer’s disease via candidate targeting of ACHE, S1PR5, SERPINE1, and TOP2A: an integrative computational and cellular study
BackgroundAlzheimer’s disease (AD) and its prodromal mild cognitive impairment (MCI) lack effective disease-modifying therapeutic strategies. Gastrodin (GAS), the major bioactive compound of Gastrodia elata, exhibits pronounced neuroprotective effects. However, the precise candidate molecular…
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Journal Article
Patterns and appropriateness of antipsychotic prescribing in community-dwelling older adults: a retrospective study
BackgroundAntipsychotics carry substantial risk in older adults, yet their use among community-dwelling outpatients remains insufficiently characterized in Saudi Arabia, where most prior work examined potentially inappropriate medications broadly or within psychiatric services. This study assessed…
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Journal Article
Berberine and celecoxib synergistically suppress non-small cell lung cancer with EGFR/AKT/COX-2-related signaling: network pharmacology, molecular docking and experimental validation
BackgroundNon-small cell lung cancer (NSCLC) remains a major cause of cancer-related mortality, and safer combination strategies with improved antitumor efficacy are still needed. Berberine (BBR), a natural isoquinoline alkaloid with multi-target pharmacological activity, and celecoxib (CXB), a…
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Journal Article
Navigating neonatal thrombosis: contemporary insights into a complex disorder in a unique population
Neonatal thromboembolic disease (TE) is an increasingly recognized clinical condition associated with significant morbidity, despite its relatively low incidence in the general paediatric population. Neonates-especially those in Neonatal Intensive Care Units (NICUs)-are at the highest risk for TE…
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Journal Article
Placental alkaline phosphatase promotes lipid accumulation and fibrosis in ligamentum flavum hypertrophy and represents a potential target for statin repurposing
Background and objectiveLumbar spinal stenosis is a prevalent degenerative disorder driven primarily by ligamentum flavum hypertrophy. Emerging evidence links ectopic lipid accumulation to fibrotic remodeling and suggests a potential contribution of immune dysregulation. However, the molecular…
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Journal Article
Potential role of resveratrol in abdominal cocoon syndrome: targeting inflammation, oxidative stress, and fibrosis via food-derived bioactive compounds resveratrol for treatment of abdominal cocoon syndrome
Abdominal cocoon syndrome (ACS) is a rare refractory peritoneal fibrotic disease marked by intestinal encapsulation by dense fibrous membranes. Its pathogenesis involves chronic inflammation, oxidative stress, pathological angiogenesis, immune dysregulation and peritoneal fibrosis, and targeted…
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Journal Article
Thioredoxin system: mechanisms and therapeutic potential in mental disorders
Mental disorders, including depression, schizophrenia (SCZ), autism spectrum disorders (ASD), and substance use disorders (SUD), impose a substantial global disease burden. The pathogenesis of these diseases is complex and not fully understood, which limits the therapeutic efficacy of existing…
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Journal Article
From respiratory viral infection to persistent cough hypersensitivity: neuroimmune regulation and therapeutic implications of P2X3/TRP ion-channel targets
Respiratory viral infections are increasingly recognized as important drivers of persistent airway symptoms and exacerbations in chronic lung disease. Post-infectious cough (PIC), particularly after upper respiratory tract infection, represents one of the most frequent causes of subacute cough and…
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Journal Article
Targeting the secretory autophagy–extracellular vesicle interface: fate decisions and translational opportunities
Autophagy preserves cellular homeostasis through lysosomal degradation, but its machinery also participates in extracellular release. This creates a pharmacological problem: changing autophagy or extracellular vesicle (EV) output can alter intracellular disposal, inflammatory signaling and…
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Journal Article
Innate immunity and hypertension: unveiling inflammatory pathways for novel therapies
Hypertension is a leading cause of global cardiovascular morbidity and mortality, yet its primary etiology remains poorly defined. Accumulating evidence increasingly positions inflammation as a key determinant of disease progression, with both innate and adaptive immune mechanisms playing central…
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Journal Article
Indication-specific adverse event profiles of semaglutide and liraglutide: a FAERS disproportionality analysis
ObjectiveBy 2021, regulatory agencies had approved two glucagon-like peptide-1 receptor agonists (GLP-1RAs), semaglutide and liraglutide, for the treatment of type 2 diabetes and obesity. Since then, concerns have emerged about whether adverse events (AEs) differ by GLP-1RA or indication.Research…
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