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Artikel Jurnal
Seawater pearl hydrolysate alleviates perimenopausal syndrome by modulating hypothalamic and uterine ERα/MAPK/CREB signaling in ovariectomized rats
BackgroundPerimenopausal syndrome (PMS), characterised by hormonal imbalance resulting from ovarian aging, causes various symptoms that significantly impair quality of life. Current hormone replacement therapy carries potential risks; thus, safer alternatives are needed. This study investigated the…
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Artikel Jurnal
Evaluation of Andrographis paniculata in a mouse model of influenza A viral infection using oral administration and a translationally relevant dose
IntroductionEthnobotanically, Andrographis paniculata aerial parts have been used to alleviate the symptoms of viral infections, colds, and sore throats. Although the utility of Andrographis for these indications has had widespread acceptance, multiple knowledge gaps, regarding mechanisms and…
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Artikel Jurnal
Comparative analysis of bioactivities of leaf extracts from wild plant species Verbascum sinuatum, Amaranthus spinosus, Carduus getulus, and Heterotheca subaxillaris collected in Gaza Strip, Palestine
Traditional medicinal plants are valuable sources of bioactive compounds, many acting synergistically and their therapeutic uses are increasingly recognized. In this study, we examined the antimicrobial activity, antioxidant potential, and phytochemical constituents of four traditional medicinal…
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Artikel Jurnal
Mesenchymal stem cell-derived exosomes in myocardial infarction repair: therapeutic potential and scaffold-based delivery strategies
Myocardial infarction (MI) remains a leading cause of global mortality, with current therapeutic modalities offering limited capacity for complete myocardial tissue regeneration. Advances in regenerative medicine have introduced stem cell-based approaches, among which mesenchymal stem cells (MSCs)…
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Artikel Jurnal
Sacubitril/valsartan mitigates cisplatin-induced liver injury through modulation of oxidative stress, Caspase-3 activity, and RXR-α signaling in experimental rats
BackgroundCisplatin (CIS) is a highly effective chemotherapeutic agent widely used to treat solid tumors. However, its clinical use is significantly limited by dose-dependent hepatotoxicity, characterized by hepatocellular injury and apoptosis. Despite extensive research efforts, an effective…
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Artikel Jurnal
A novel pyrrolidine-chalcone derivative exhibits synergistic anti-cervical cancer activity by dual-targeting MDM2-p53 axis and ferroptosis pathway
IntroductionCervical cancer remains a serious threat to women’s health, driving the need for effective and low-toxicity therapeutics. This study designed novel pyrrolidine-chalcone derivatives targeting the MDM2-p53 interaction.MethodsA series of compounds were synthesized and evaluated for…
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Artikel Jurnal
GTX-11 attenuates lung fibrosis, inflammation and vascular remodeling in preclinical models of lung fibrotic disease
BackgroundFibrotic interstitial lung diseases (ILDs) are characterized by different degrees of inflammation and fibrosis of the lung parenchyma that are associated with progressive loss of breath, high morbidity and mortality. Current therapeutic options are limited, so there remains a significant…
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Artikel Jurnal
Induction of immunogenic cell death by active components of natural products reshaping the tumor microenvironment for enhanced antitumor immunity
BackgroundThe immunosuppressive tumor microenvironment (TME) is a principal factor limiting the success of current cancer immunotherapies. Immunogenic cell death (ICD), a process whereby dying tumor cells elicit an adaptive immune response through the emission of damage-associated molecular…
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Progress on new drug treatments for hepatic echinococcosis
Echinococcosis: is a zoonotic parasitic disease caused by infection with the larvae of Echinococcus tapeworms. At present, the standardized treatment regimen for this disease consists of radical lesion resection combined with albendazole. For patients who are inoperable or experience postoperative…
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Artikel Jurnal
Wuji Wan ameliorates ulcerative colitis by restoring impaired membrane transport
IntroductionWuji Wan (WJW) is a classical Chinese formula traditionally prescribed for diarrhea/dysentery and abdominal pain. In ulcerative colitis (UC), inflammatory diarrhea reflects not only mucosal inflammation but also inflammation-linked disruption of epithelial electrolyte and water…
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Artikel Jurnal
Safety and efficacy of different JAK inhibitors in the treatment of inflammatory bowel disease: a network meta-analysis
Targeting the Janus kinase (JAK) signaling pathway is a new way to treat inflammatory bowel disease (IBD). This network meta-analysis aimed to compare the efficacy and safety of various JAK inhibitors, including brepocitinib, filgotinib, ivarmacitinib, peficitinib, ritlecitinib, tofacitinib, and…
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Artikel Jurnal
Case Report: A patient harboring rare EGFR S768I/V769L compound mutation benefited from afatinib and osimertinib
BackgroundThe development of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) dramatically altered the treatment for non-small cell lung cancer (NSCLC). The implementation of comprehensive genomic profiling for NSCLC facilitates to identify more uncommon genetic alterations…
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Artikel Jurnal
Spectrum mining of immune checkpoint inhibitor-related cutaneous toxicities and analysis of associated factors based on FAERS
ObjectiveThe study sought to delineate the cutaneous toxicity spectrum of immune-checkpoint inhibitors by using the US FDA Adverse Event Reporting System, and to qualify association with other immune-related adverse events (irAEs).MethodsDisproportionality analyses relied on Reporting Odds Ratio…
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