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Artikel Jurnal
Cannabinoids in oncology: pharmacology, clinical applications, and translational perspectives
Cannabis and cannabinoid products are increasingly used by patients with cancer for symptom management and supportive care. Although cannabis is widely used to alleviate cancer- and treatment-related symptoms, many patients also believe that it possesses direct anticancer activity. This review…
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Artikel Jurnal
A review of advances in research on mechanisms inhibiting kidney stone formation from a network pharmacology perspective
Nephrolithiasis is a prevalent, highly recurrent urological disorder affecting 1%–15% of the global population, with 5-year recurrence rates reaching up to 50%. While surgical interventions achieve acute stone clearance, they do not resolve underlying metabolic derangements, crystal-induced tubular…
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Artikel Jurnal
Extracellular vesicle-mediated preconditioning of osteoblasts by ER+ breast cancer cells: implications for the bone metastatic niche
Breast cancer metastasis to bone most commonly occurs in late-stage disease and remains a major contributor to morbidity, reduced quality of life, and mortality, particularly in estrogen receptor-positive (ER+) tumors. Intercellular communication between tumor cells and bone-resident cells plays a…
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Artikel Jurnal
The postantibiotic effect-like effect of photothermal agents: evidence from IR780 nanoparticles and indocyanine green
IntroductionPostantibiotic effect (PAE) refers to the temporary suppression of bacterial growth after transient antimicrobial treatment. In recent years, due to the spread of antibiotic resistance, photothermal agents (PTAs) have been broadly studied for infection treatments. However, the PAE-like…
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Artikel Jurnal
Mapping the antileishmanial structure-activity relationship of eugenol
Leishmaniasis is a neglected tropical disease with a devastating global impact. The current medications on the market for treating this protozoan parasitic infection are insufficient to fit the global need, with long durations of therapy, growing resistance rates, and severe adverse effects. This…
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Artikel Jurnal
MitoQ in sepsis-associated acute lung injury: redox pharmacology, mechanistic evidence, and translational perspectives
Sepsis-associated acute lung injury (SALI) is characterised by mitochondrial oxidative stress, bioenergetic dysfunction, dysregulated inflammation, and disruption of the alveolar–capillary barrier. MitoQ is a mitochondria-targeted redox modulator with experimental evidence of mitochondrial and…
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Artikel Jurnal
Handling missed dose of riluzole by population pharmacokinetic model informed remedial regimen
BackgroundPatients with amyotrophic lateral sclerosis (ALS) frequently exhibit nonadherence characterized by delayed or missed doses while taking riluzole. This study aimed to provide a population pharmacokinetic (PPK) model informed individualized remedial regimens for patients who experience…
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Artikel Jurnal
Personalized anticoagulant therapy in venous thromboembolism: current role of direct oral anticoagulants, unmet clinical needs, and future perspectives on Factor XI inhibition
Venous thromboembolism (VTE), encompassing deep vein thrombosis and pulmonary embolism, remains a major cause of morbidity and mortality worldwide. The introduction of direct oral anticoagulants (DOACs) has transformed the management of VTE by providing effective and convenient alternatives to…
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Artikel Jurnal
Multimodal molecular representation and property prediction based on structured complementary feature fusion
In this work, we propose Molrep-SCF, a multimodal self-supervised pretraining framework for molecular representation learning using SMILES sequences, 2D molecular graphs, and 3D geometric structures. The three modalities are encoded using a Transformer, a graph neural network, and an invariant 3D…
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Artikel Jurnal
Chicoric acid-rich extract of Cichorium intybus seeds (CAREOCI) preserves pancreatic β-cell function under glucotoxic stress through modulation of MAFA, DYRK1A, cell cycle, apoptosis, and mitochondrial dysfunction
IntroductionProgressive decline in functional pancreatic β-cell mass is a key pathological feature of type 2 diabetes mellitus (T2DM), highlighting the need for therapies that preserve and regenerate β-cells. This study investigated the preservative effects of a chicoric acid-rich aqueous extract…
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Artikel Jurnal
Apelin aggravates inflammatory response and hepatic steatosis in alcohol-associated liver disease via ERK signaling pathway
BackgroundThough apelin is involved in cardiovascular, metabolic, and homeostasis disorders, its role in alcohol-associated liver disease (ALD) remains unclear. This study aimed to investigate the mechanism of apelin in promoting hepatic inflammation in ALD.MethodsRAW 264.7 macrophages and a…
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Artikel Jurnal
Protective effects of cannabidiol against acute stress: behavioral responses and corticosterone concentrations in female Wistar rats
BackgroundCannabidiol (CBD) has been widely investigated for its potential anxiolytic and stress-modulating effects. This study evaluated whether CBD reduces the stress response induced by acute restraint stress in rats.MethodsThirty-six female Wistar rats were randomly assigned to six groups. Four…
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Artikel Jurnal
Antispasmodic and analgesic strategies for renal colic in pregnancy: a comprehensive analysis
BackgroundAnalgesia remains the paramount priority in the clinical management of gestational renal colic, yet established protocols are frequently constrained by contraindications. While antispasmodic intervention emerges as a viable alternative, the definitive pharmacological choice remains…
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Artikel Jurnal
Monoclonal antibodies associated IgA nephropathy or other nephropathies
The use of monoclonal antibodies (mAbs) has revolutionized the treatment of autoimmune, inflammatory, and neoplastic diseases. However, accumulating evidence indicates that biologic therapies may be associated with renal adverse events, including various types of glomerulonephritis. The aim of this…
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Artikel Jurnal
A meta-analysis of berberine combined with brain-gut axis-targeted agents for diarrhoea-predominant irritable bowel syndrome
BackgroundThe prevalence of diarrhoea-predominant irritable bowel syndrome (IBS-D) is high and significantly impairs patient quality of life. Berberine, a naturally occurring isoquinoline alkaloid, shows promise in combination with brain-gut axis-targeted drugs for relieving abdominal pain…
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Artikel Jurnal
Chemically modified gelatin derivatives: synthetic strategies, physicochemical properties, biodegradation, drug delivery and biomedical applications
Gelatin, the hydrolysate of collagen, has been used as a food ingredient as well as a pharmaceutical excipient since ancient times. Of late, it has attracted renewed interest as a constituent of drug delivery systems (DDS) because of its amicability to easily transform into various structural forms…
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Artikel Jurnal
Teaching the true cost of medicines: white paper for a green and sustainable pharmacology curriculum
The drug lifecycle imposes a growing environmental burden, evident in pharmaceutical pollution, escalating consumption of finite resources (energy, water, and raw materials) and a substantial carbon footprint. Meeting these challenges requires more than technological fixes; it demands a workforce…
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Artikel Jurnal
Efficacy and safety of first- versus second-generation fibroblast growth factor receptor (FGFR) inhibitors in advanced or metastatic urothelial carcinoma with FGFR alterations: a systematic review and meta-analysis
IntroductionWe reviewed the clinical studies on fibroblast growth factor receptor (FGFR) inhibitors for the treatment of urothelial carcinoma to conduct the meta-analysis of clinical efficacy and safety, aiming to provide more precise treatment options for patients with FGFR alterations.MethodWe…
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Artikel Jurnal
Emerging insights of bile acids in cardiovascular physiology and disease: from molecular mechanisms to therapeutic potential
Cardiovascular diseases (CVDs) are among the leading causes of mortality and morbidity globally, with diverse etiologies including hypertension, diabetes mellitus, and hyperlipidemia. In recent years, increasing evidence highlights that abnormal metabolism serves as a significant part in the…
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