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Artikel Jurnal
Research trends of nanotechnology in coronary heart disease: a bibliometric analysis from 2012 to 2025
BackgroundCoronary heart disease (CHD) remains a leading cause of mortality worldwide, with conventional therapeutic strategies limited by non-specific targeting, low bioavailability, and systemic off-target effects. Nanomaterials, leveraging their unique physicochemical properties, have shown…
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Artikel Jurnal
A pathway to next-generation mast cell stabilizers identified through the novel Phytomedical Analytics for Research Optimization at scale data platform
IntroductionMast cell stabilizers (MCS) have the potential to address unmet therapeutic need in allergy and inflammation management. MCS chronically suppress all arms of the pro-inflammatory mast cell response to stimulation (e.g., histamine, protease, lipid mediators, cytokines and chemokines)…
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Artikel Jurnal
Phenolic metabolites from Ceratonia siliqua L. pods: chemical characterization, soybean lipoxygenase-1 inhibition, and in vitro gallstone-dissolving capacity
IntroductionCarob (Ceratonia siliqua L., Fabaceae) is a Mediterranean tree whose pods are rich in phenolic metabolites and are credited with antioxidant, anti-inflammatory,hypolipidemic and antimicrobial properties.MethodsThe chemical composition of MECp was determined by high-performance liquid…
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Artikel Jurnal
Stroboscopic light stimulation as a controllable probe of the psilocybin state: a mechanistic framework and a falsifiable prediction
Stroboscopic light stimulation (SLS) and psilocybin each induce altered states whose phenomenology and neurophysiology partly overlap, including posterior alpha-band changes and visual imagery. The two states engage the alpha band through different operations - pharmacological suppression under…
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Artikel Jurnal
Dynamic kinetics of graft-derived cell-free DNA and personalized tacrolimus target ranges for acute rejection monitoring in pediatric liver transplantation
IntroductionAcute rejection remains the most common complication during the early post-transplantation period for pediatric patients. Given the limitations of current diagnostic strategies, there is an urgent need to develop accurate and noninvasive biomarkers for allograft monitoring…
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Artikel Jurnal
Jaungo-based herbal complex regulates psoriasis-associated macrophage–keratinocyte inflammatory axis
Background/ObjectivesPsoriasis is a chronic inflammatory skin disease characterized by dysregulated cross-talk between macrophages and keratinocytes, resulting in excessive cytokine signaling and impaired epidermal barrier function. Traditional Jaungo has long been used as a topical remedy for…
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Artikel Jurnal
Epithelial cell–based multi-omics integration identifies SPINK5 and SRI as novel diagnostic biomarkers for ulcerative colitis
ObjectivesUlcerative colitis (UC) is a chronic inflammatory bowel disease characterized by epithelial barrier dysfunction, yet reliable epithelial-derived diagnostic biomarkers remain elusive.MethodsWe employed an integrative multi-omics approach, combining single-cell RNA sequencing (scRNA-seq)…
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Artikel Jurnal
Research progress on Bergenia purpurascens: a narrative review
Bergenia purpurascens (Hook.f.et Thoms.) Engl., a perennial herb belonging to the genus Bergenia (family Saxifragaceae), is primarily distributed in southwestern China and mountainous regions of Nepal, Bhutan, and northeastern India, where it has a long history of medicinal use. A systematic…
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Efficacy and neuroprotective effects of tetramethylpyrazine in animal models of spinal cord injury: a systematic review, meta-analysis, and exploratory machine-learning study
BackgroundSpinal cord injury (SCI) is a severe neurological disorder characterized by persistent motor dysfunction and complex secondary injury processes. Tetramethylpyrazine (TMP) has shown potential neuroprotective effects in experimental SCI; however, the overall efficacy and factors associated…
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Adjunctive Acorus tatarinowii essential-oil ear-canal packing for idiopathic sudden sensorineural hearing loss: study protocol for a single-center, randomized, double-blind, placebo-controlled clinical trial
BackgroundIdiopathic sudden sensorineural hearing loss (ISSNHL) is an acute otologic emergency, and hearing recovery remains highly variable and frequently unsatisfactory. Acorus tatarinowii Schott has long been used in traditional Chinese medicine to treat hearing impairment and related auditory…
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Artikel Jurnal
Case Report: Pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome misdiagnosed as ovarian malignancy
BackgroundHepatic Sinusoidal Obstruction Syndrome (HSOS), formerly known as Hepatic Veno-Occlusive Disease (HVOD), is a rare and life-threatening liver condition. It is often caused by the ingestion of pyrrolizidine alkaloids (PAs), which are found in plants such as Gynura segetum (Tusanqi)…
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Artikel Jurnal
Four-week supplementation with a blackcurrant formulation enhances cognitive performance, reduces mental fatigue and modulates peripheral monoamine metabolism in older adults: a randomized, double-blind, placebo-controlled, crossover study
IntroductionAge-related cognitive decline is an increasing concern in older adults. While blackcurrants (Ribes nigrum) have shown promise in improving cognitive outcomes in younger adults, their efficacy in supporting cognitive function in older adults is largely unexplored.MethodsIn this…
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Artikel Jurnal
The selective SIK2/3 inhibitor GLPG3970 exhibits antidepressant-like effects via the hippocampal SIK2-CRTC1-CREB-BDNF pathway in chronic stress models
IntroductionDepression is a common mental disorder driven by biopsychosocial factors. Although traditional antidepressants serve as first-line therapies, they face clinical challenges, underscoring the need for novel therapeutic agents with improved efficacy. Our previous studies have identified…
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Soluble guanylate cyclase modulation in heart failure and chronic kidney disease: mechanisms, clinical evidence, and translational boundaries
Heart failure (HF) and chronic kidney disease (CKD) frequently coexist and amplify one another through hemodynamic, neurohormonal, inflammatory, oxidative, and microvascular mechanisms. Impaired nitric oxide (NO)–soluble guanylate cyclase (sGC)–cyclic guanosine monophosphate (cGMP)–protein kinase G…
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Online adaptive E-tutorials for development of critical appraisal skills
Critical appraisal of research literature is an important skill for graduates yet science graduate employers report dissatisfaction with skill levels. As scaffolding can assist in critical appraisal development, we aimed to develop and evaluate 2 adaptive e-tutorials for critical appraisal…
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Artikel Jurnal
Early disease control with a biochemical response to aumolertinib after postoperative recurrence of EGFR-Mutant stage IIIA lung adenocarcinoma after icotinib, with EGFR T790M detected at recurrence: a Case Report
BackgroundEpidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are a standard treatment for EGFR-mutant non-small cell lung cancer (NSCLC). However, acquired resistance commonly develops after treatment with first- or second-generation EGFR-TKIs. Aumolertinib, a third-generation…
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Artikel Jurnal
Ensemble signal detection reveals target-specific temporal risk of hypokalemia after immune checkpoint inhibition: a translational pharmacology framework
IntroductionImmune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, but traditional pharmacovigilance lacks a translational computational framework capable of resolving target-specific nonlinear temporal risks of adverse events such as hypokalemia.MethodsWe integrated 3,243…
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Artikel Jurnal
Emerging links between TLR4 signaling and ferroptosis in heart failure
Iron is an essential nutrient for living organisms, and the maintenance of its homeostatic balance within the body is a critical factor in ensuring normal physiological functions. Cardiomyocyte ferroptosis has emerged as a potential contributor to heart failure progression, involving complex…
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