31,912 results
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Journal Article
PMEPA1 attenuates myocardial ischemia-reperfusion injury via interaction with NEDD4 and involvement of the TGF-β/SMAD pathway
IntroductionMyocardial ischemia-reperfusion injury (MIRI) remains a significant challenge in cardiovascular medicine, and its molecular mechanisms are not yet fully elucidated.MethodsIn the present study, integrated transcriptomic analysis combined with machine learning identified PMEPA1 as a key…
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Journal Article
Targeting glial modulation: molecular mechanisms of Polygonatum in neurological disorders
Neurological disorders arise from interconnected pathological processes, including oxidative stress, neuroinflammation, mitochondrial dysfunction, impaired proteostasis, synaptic injury and blood brain barrier disruption. Increasing evidence indicates that glial cells are not passive bystanders in…
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Journal Article
Outcomes reported in randomized controlled trials of traditional Chinese medicine for chronic pharyngitis: a scoping review
PurposeEvidence synthesis of traditional Chinese medicine (TCM) interventions for chronic pharyngitis is hindered by substantial variation in the outcomes selected and reported across clinical trials. This scoping review aimed to systematically map the outcomes reported in randomized controlled…
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Journal Article
Clinical evaluation of compound jinji granules in the treatment of primary premature ejaculation: a multicenter, randomized, double-blind, double-dummy, controlled trial
BackgroundPrimary premature ejaculation (PPE) affects men’s sexual confidence, impairs couple relationships, and may lead to anxiety and depression. Compound Jinji Granule (CJG) is a traditional Chinese medicine (TCM) formula for treating PPE. Preliminary rat experiments suggested its potential in…
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Journal Article
Timing dictates efficacy: evaluating the prophylactic and therapeutic potential of dimethyl fumarate against LPS-induced shock
BackgroundAcute kidney injury (AKI) is a serious and often fatal condition that is caused by endotoxemia as a result of systemic inflammation and uncontrolled oxidative stress. Although dimethyl fumarate (DMF) has shown to have immunomodulatory and antioxidant activity, its specific prophylactic…
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Journal Article
Comparative efficacy and safety of four immunomodulatory agents for acute spinal cord injury: a systematic review and Bayesian network meta-analysis
Study DesignSystematic review and Bayesian network meta-analysis.ObjectiveTo compare the efficacy and safety of methylprednisolone (MP), erythropoietin (EPO), granulocyte colony-stimulating factor (G-CSF), and minocycline for the treatment of acute spinal cord injury (ASCI).MethodsMEDLINE, Embase…
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Journal Article
The future of brain tumor treatment: integrating platelet-based liquid biopsy, advanced drug delivery systems, and eicosanoid inhibition
Despite extensive research, brain tumors still have some of the lowest survival rates among cancers. Their marked resistance to both conventional and emerging therapies stems from the unique properties of neural cells and their microenvironment, including the blood-brain barrier, cellular…
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Journal Article
Efficacy and safety of nafamostat mesilate for anticoagulation during ECMO/CRRT: insight from the integrated meta-analysis and FAERS pharmacovigilance study
BackgroundExtracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT) require a balance between maintaining circuit patency and minimizing bleeding risk. Nafamostat mesilate (NM) is a short-acting anticoagulant with distinctive pharmacokinetic properties, including…
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Journal Article
Pharmacometabolomic signatures as individualised biochemical response evidence: towards a precision jurisprudence framework for forensic toxicology and criminal responsibility
Precision medicine is transforming drug response from a population level assumption into an individualised biochemical event. Pharmacometabolomics, which profiles metabolic signatures associated with drug exposure and response, offers a mechanistic basis for explaining interindividual variability…
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Journal Article
Revolutionizing transdermal drug delivery evaluation: the evolution from traditional models to skin organoids and the integration of artificial intelligence
This review examines the evolution of evaluation systems for transdermal drug delivery systems (TDDS) alongside recent advances in skin organoids (SkOs). We discuss the potential of SkOs as in vitro models, with particular attention to their structural complexity and their ability to recapitulate…
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Journal Article
Machine-learning phenotyping and exploratory medication-outcome associations in heart failure with preserved ejection fraction: a multicohort retrospective study
BackgroundThe marked clinical and pathophysiological heterogeneity of HFpEF has repeatedly undermined uniform treatment strategies. Consequently, identifying distinct phenotypes and medication-associated patterns across phenotypes may inform future precision-medicine research.MethodsIn this…
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Journal Article
Integrated proteomic and metabolomic analysis reveals the mechanism of astragalus complanatus flavonoids against liver fibrosis in rats
ObjectiveAstragali Complanati Semen (ACS) is a traditional Chinese medicinal herb conventionally applied to tonify the liver and kidney. As the primary bioactive ingredients of ACS, Astragalus complanatus flavonoids (ACF) exert hepatoprotective and anti-fibrotic effects. This study aimed to…
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Journal Article
A non-destructive methodological framework for modernizing legacy clinical reporting systems for AI-driven pharmacoinformatics: a SAS case study
Legacy clinical reporting pipelines bottleneck drug development and pharmacovigilance: they encode regulatory-grade analytical logic but produce opaque output with no machine-readable intermediate layer, resisting integration with artificial intelligence (AI). Existing modernization approaches…
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Journal Article
Hepatoprotective Formula 919 ameliorates hepatic steatosis and metabolic disturbance in NAFLD with involvement of AMPK signaling
BackgroundNon-alcoholic fatty liver disease (NAFLD) is characterized by hepatic lipid accumulation and metabolic dysregulation, while effective therapeutic options remain limited. Hepatoprotective Formula 919 (HF919), a traditional Chinese herbal formulation, has shown hepatoprotective effects, but…
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Journal Article
Natural product-derived interventions for reversing multidrug resistance in resistant K562 leukemia cells: a systematic review and meta-analysis
BackgroundMultidrug resistance remains a major barrier to effective chemotherapy for leukemia. Natural product-derived interventions have been widely investigated as modulators of drug resistance in adriamycin- or doxorubicin-resistant K562 cell models, but their quantitative reversal effects…
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Journal Article
Targeting the PCSK9–PR–IL-17 axis for psoriasis therapy
IntroductionPsoriasis is a chronic, immune-mediated inflammatory dermatosis characterized by keratinocyte hyperproliferation and systemic metabolic comorbidities. Although proprotein convertase subtilisin/kexin type 9 (PCSK9) is a well-established regulator of lipid metabolism, its role in the…
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Journal Article
Rituximab with low-dose glucocorticoids for treating refractory membranous nephropathy: a prospective single-center cohort study
BackgroundRituximab (RTX) is the first-line treatment for primary membranous nephropathy (pMN), yet approximately one-third of patients exhibit refractory disease. Evidence supporting RTX combined with low-dose glucocorticoids for refractory pMN remains limited. This study aimed to evaluate the…
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Journal Article
Ocular safety signals of sphingosine-1-phosphate receptor modulators in postmarketing surveillance
BackgroundSphingosine-1-phosphate (S1P) receptor modulators are used for immune-mediated diseases, and macular oedema is an established ocular adverse effect. However, ocular-focused, class-wide postmarketing reporting across all five approved agents remains incompletely characterized.MethodsWe…
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Journal Article
ALKBH5 inhibitors for cancer therapy: molecular docking, challenges and future prospects
N6-Methyladenosine (m6A), the most abundant internal modification of eukaryotic mRNA, is dynamically reversed by the FeII/α-ketoglutarate-dependent dioxygenase ALKBH5, a key m6A “eraser” that regulates target mRNA fate through demethylation. ALKBH5 is aberrantly overexpressed in acute myeloid…
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