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Artikel Jurnal
Beyond angiogenesis: the paradoxical emerging pro-tumorigenic role of Thrombospondin-2
The tumor microenvironment is a complex ecosystem where the extracellular matrix serves as a dynamic signaling hub and regulates tumorigenesis. Thrombospondin-2 (THBS2), a matricellular extracellular matrix protein, has traditionally been regarded as an inhibitor of angiogenesis. However, emerging…
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Artikel Jurnal
Targeting the Correa’s cascade of gastric cancer: the potential role of phytochemicals and autophagy modulation
Gastric cancer (GC) development follows a sequential and complex pathophysiological process known as Correa’s cascade, progressing from chronic gastritis (active or inactive) to precancerous lesions (intestinal metaplasia (IM) and dysplasia) and ultimately to adenocarcinoma. Current GC therapies…
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Artikel Jurnal
Astragaloside IV in hepatocellular carcinoma: repolarizing macrophages to reprogram the tumor microenvironment
The establishment of an immunosuppressive tumor microenvironment (TME) represents a central mechanism underlying the failure of conventional therapies and resistance to immunotherapy in hepatocellular carcinoma (HCC). Tumor-associated macrophages (TAMs), as the most abundant immune cell population…
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Artikel Jurnal
Targeting lysosomal ion channels to overcome cancer treatment resistance: emerging mechanisms and therapeutic opportunities
Lysosomes are critical cellular organelles that not only regulate metabolic regulation but also play pivotal roles in cell death, signal transduction, and tumorigenesis. The various ion channels expressed on the lysosomal membrane are central to these physiological functions; they intricately…
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Artikel Jurnal
Cannabinoids in hematologic malignancies: mechanisms and therapeutic potential for overcoming drug resistance
Hematologic malignancies are highly heterogeneous diseases in which the emergence of therapy resistance remains a major obstacle to durable clinical benefit. Cannabinoids, acting through the endocannabinoid system, have drawn increasing interest because of their potential to modulate multiple…
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Artikel Jurnal
APOE4 differentially alters lipid composition in extracellular vesicles from hiPSC-derived neurons of Alzheimer’s disease patients
BackgroundThe Apolipoprotein E4 (APOE4) is the most significant genetic risk factor for late-onset Alzheimer’s disease (AD), but the cellular mechanisms by which it increases vulnerability remain poorly understood. Lipids play a crucial role in membrane organization, vesicle trafficking, and…
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Artikel Jurnal
Insights into osteoporosis triggered by common antiepileptic drugs via network toxicology, molecular docking and molecular dynamics simulations
BackgroundAntiepileptic drugs (AEDs), first-line treatments for epilepsy and related seizure disorders, are increasingly recognized as important risk factors for osteoporosis. However, the molecular mechanisms and specific targets underlying AED-induced bone loss remain largely unclear.MethodsWe…
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Artikel Jurnal
Natural metabolites targeting macrophage polarization for non-small cell lung cancer therapy: a review of mechanisms and applications based on chemical classification
Non-small cell lung cancer (NSCLC) accounts for roughly 85% of lung cancer cases and is a leading cause of cancer-related death worldwide. Reprogramming tumor-associated macrophages (TAMs) from a pro-tumor M2 phenotype to an anti-tumor M1 phenotype has emerged as a promising therapeutic strategy…
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Artikel Jurnal
Resistance mechanisms and reversal strategies of PD-1/PD-L1 inhibitors in melanoma
Programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) immune checkpoint inhibitors have redefined the therapeutic landscape of advanced melanoma, establishing a first-line standard of care that markedly prolongs patient survival. Nevertheless, primary and acquired resistance…
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Artikel Jurnal
Bioactive compounds from Perilla frutescens modulate multiple cell death pathways and signaling networks in cancer therapy
Perilla frutescens, an edible medicinal plant from East Asia, produces diverse bioactive phytochemicals with anticancer activity, including perillaldehyde (PAH), rosmarinic acid (RA), luteolin, apigenin, and alpha-linolenic acid (ALA). These compounds exert multi-target anticancer effects through…
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Artikel Jurnal
B7-H3-mediated immune regulation in cancer: biological functions and therapeutic opportunities
B7-H3 (CD276), a member of the B7 family of immunoregulatory ligands, has emerged as an important molecule at the intersection of tumor biology and cancer immunology. Although initially identified as a regulator of T-cell responses, accumulating evidence supports its predominantly immunosuppressive…
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Artikel Jurnal
Traditional Chinese medicine (TCM)-based nanoformulations for cancer therapy: antitumor mechanisms, challenges, and future directions
Background/ObjectivesTraditional Chinese medicine (TCM)-derived compounds have anticancer potential because of their multi-component, multi-target actions and generally favorable toxicity profiles. Clinical translation, however, is limited by poor aqueous solubility, rapid systemic metabolism, and…
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Artikel Jurnal
Selective behavioral and prefrontal transcriptomic correlates of acute clozapine exposure in socially isolated mice
BackgroundClozapine is an effective antipsychotic for treatment-resistant schizophrenia, but acute molecular responses to clozapine remain incompletely characterized. Social isolation rearing produces schizophrenia-relevant behavioral abnormalities and permits joint evaluation of housing and drug…
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Artikel Jurnal
Efficacy and safety of antibody-drug conjugates in pretreated HER2-positive advanced breast cancer: a network meta-analysis of randomized controlled trials
BackgroundAntibody-drug conjugates (ADCs) have become the standard treatment for HER2-positive(HER2+)advanced breast cancer following the failure of trastuzumab or taxane. Nevertheless, there are no direct head-to-head trials comparing different ADCs.MethodsWe searched PubMed, Embase, the Cochrane…
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Artikel Jurnal
Lactylation in liver fibrosis: from molecular mechanisms to targeted therapeutic strategies
Metabolic reprogramming and epigenetic remodeling of hepatic stellate cells (HSCs) represent central driving events in liver fibrosis. Lactylation, a lactate-mediated post-translational modification (PTM), is proposed to converge on histone H3 lysine 18 lactylation (H3K18La) through the HK2-KAT8…
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Artikel Jurnal
Clinical outcomes following a traditional Chinese medicine foot bath preparation for lower-limb edema and sleep disturbance: a single-center retrospective study of 2,000 patients
ObjectiveTo evaluate clinical outcomes and documented adverse events following treatment with a traditional Chinese medicine (TCM) foot bath preparation in patients with lower-limb edema and sleep disturbance.MethodsThis single-center retrospective observational study included 2,000 patients…
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Artikel Jurnal
Integrated counter current separation and omics approaches for discovery of bioactive compounds from medicinal plants
Medicinal plants provide an important source of structurally varied bioactive metabolites with medicinal potential; however, their effective extraction, characterization, and standardization present considerable analytical challenges. Counter-current separation (CCS) methods, such as centrifugal…
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Artikel Jurnal
Screening traditional Chinese medicine monomers for premature ovarian insufficiency: from network meta-analysis to the effects of a promising candidate on oxidative stress biomarkers
BackgroundTherapeutic options for premature ovarian insufficiency (POI) are limited, and the comparative efficacy of traditional Chinese medicine (TCM) monomers remains unclear. This study aimed to systematically evaluate and rank the efficacy of various TCM monomers in animal models of POI and to…
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