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Artikel Jurnal
Profiling crystal engineered ligands for targeting treatment resistant androgen receptors
IntroductionProstate cancer (PCa) is one of the principal contributors to health burden in the aging male population. PCa develops through dysregulation of androgen receptor (AR) signaling pathways. Despite improvements in diagnostic techniques and interventions, no pharmacological measures with…
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Artikel Jurnal
Exploratory pharmacokinetic/pharmacodynamic range of tigecycline for balancing treatment effect and safety in hospital-acquired pneumonia: a retrospective cohort study
IntroductionTigecycline (TGC) is a core antibiotic for treating hospital-acquired pneumonia (HAP) caused by multidrug-resistant (MDR) bacteria, but the absence of individualized dosing guidance that balances treatment effect and safety frequently results in suboptimal efficacy or…
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High-affinity ELR+ CXC chemokines display balanced G protein-, GRK- and β-arrestin-associated transducer engagement at the viral G protein-coupled receptor ORF74
Open reading frame 74 (ORF74) is the single G protein-coupled receptor (GPCR) encoded in the genome of Kaposi’s sarcoma-associated herpesvirus (KSHV). Due to its high constitutive activity and broad chemokine binding profile, ORF74 contributes to KSHV-associated diseases through autocrine and…
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Artikel Jurnal
Interaction of major monoterpenes from Rosmarinus officinalis L. essential oil with the human serotonin transporter: molecular docking, radioligand binding, and functional uptake studies
Major depressive disorder remains a leading cause of disability worldwide, and current antidepressants are limited by delayed therapeutic onset, incomplete efficacy, and adverse effects. Although Rosmarinus officinalis L. essential oil and its major monoterpenes exhibit antidepressant-like and…
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Artikel Jurnal
Berberine suppresses mechanical stretch-induced apoptosis and proliferation in vascular smooth muscle cells via ROS/PDI/Drp1 signaling pathway
BackgroundVascular smooth muscle cells (VSMCs) exhibit heterogeneous responses to mechanical stretch stress (SS), with some undergoing apoptosis and others proliferating. The mechanisms underlying this differential fate decision remain unclear.ObjectiveThis study investigated whether SS-induced…
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Artikel Jurnal
Microbiome-aware oral drug delivery: excipient–microbiome interactions and nanocarrier design rules for predictable formulation performance
Oral drug delivery remains the predominant administration route, but formulation strategies rarely account systematically for the gut microbiome. The microbiome can alter drug metabolism, excipient behavior, nanocarrier interactions, and interpatient variability. This review integrates evidence on…
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Artikel Jurnal
Ciprofol versus propofol for painless gastrointestinal endoscopy: a dose-stratified systematic review and meta-analysis
BackgroundWe compared ciprofol with propofol for painless gastrointestinal endoscopy, focusing on dose, recovery, induction, satisfaction, and adverse events.MethodsPubMed and Embase were searched through May 2026 for randomized controlled trials in adults undergoing painless gastrointestinal…
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Artikel Jurnal
Value-based pricing of brensocatib for frequently exacerbating non-cystic fibrosis bronchiectasis in China: a China-adapted, FEV1-inclusive time-dependent markov analysis
ObjectiveTo estimate a China-specific value-based annual price (P*) for brensocatib 25 mg added to standard care (SC), compared with SC alone, in adults with frequently exacerbating non-cystic fibrosis bronchiectasis, and to assess how strongly the estimate depends on transferred assumptions…
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Artikel Jurnal
Interpretable machine learning classifies β-lactamase subclasses and prioritizes boundary variants for antimicrobial resistance surveillance
IntroductionAntimicrobial resistance is a major global health threat, and β-lactamase-mediated inactivation of β-lactam antibiotics remains a leading cause of treatment failure. Rapid identification of emerging β-lactamase variants and improved understanding of their functional diversity are…
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Artikel Jurnal
Specialized pro-resolving mediators and cancer: news and promises from the other side of the moon
In physiological settings, inflammation is not passively terminated but actively resolved through coordinated endogenous programs. A central component of this response is the biosynthesis of specialized pro-resolving mediators (SPMs), including lipoxins, resolvins, protectins, and maresins. These…
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Artikel Jurnal
Pharmacological mechanisms of quercetin in liver and intestinal diseases: a gut-liver axis perspective
Hepatic and gastrointestinal disorders share interconnected pathogenic mechanisms, yet their clinical management remains challenging. This has prompted interest in therapeutic approaches targeting the gut-liver axis. Quercetin, a natural flavonoid, has been studied in this context. To assess its…
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Artikel Jurnal
CGRP remodels the acidic microenvironment and promotes pancreatic carcinoma progression by regulating NHE1 and CA9
IntroductionNeurons can regulate cancer cells to modulate their survival and growth, the interplay between calcitonin gene-related peptide (CGRP) and the acidic tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) remains unknown.Methods and ResultsHere, we reported that CGRP…
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Artikel Jurnal
Natural products targeting mitochondrial homeostasis: a four-dimensional framework integrating dynamics, mitophagy, pharmacokinetics, and translational safety
BackgroundDysregulated mitochondrial dynamics, including fission, fusion, biogenesis, and mitophagy, underlie the pathogenesis of many diseases. Natural products have the potential for multi-target therapy, but insufficient understanding of their mechanisms of action and pharmacokinetic limitations…
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Artikel Jurnal
Mechanistic mass transport analysis of dissolution of weak-base drugs considering the influence of surface pH in formulations with and without acidifying agents
At the solid–liquid interface, the dissolution of weakly basic drugs, particularly those exhibiting poor solubility, is highly sensitive to local pH conditions. These compounds frequently show pH-dependent solubility and reduced bioavailability when co-administered with acid-reducing agents, which…
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Artikel Jurnal
Gastrodin inhibits neuronal ferroptosis by regulating mir-455–5p/ACSL4 pathway after stroke via exosome
Recent studies have demonstrated that ferroptosis plays a crucial role in neuronal cell death following cerebral infarction. Our previous research showed that gastrodin (GAS) significantly improved neurological function in rats subjected to middle cerebral artery occlusion (MCAO); however, the…
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Artikel Jurnal
Bedaquiline pharmacokinetics in drug-resistant tuberculosis: from exposure variability to individualized therapy
Bedaquiline has transformed the treatment of multidrug- and rifampicin-resistant tuberculosis (MDR/RR-TB) and is now a core component of contemporary all-oral regimens. However, translating its distinctive pharmacokinetic properties into individualized clinical management remains challenging…
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Artikel Jurnal
Self-reported prescription medication use and polypharmacy following physical combat injury in the UK: the ADVANCE cohort study
IntroductionThe consequences of serious physical traumatic injury may require pharmacological intervention, however long-term use and polypharmacy can increase risk of morbidity/mortality. This study aims to describe prescription medication use in a cohort of UK Armed Forces personnel who sustained…
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Artikel Jurnal
Efficacy and safety of neurokinin-1 receptor antagonist on cough suppression: a systematic review and meta-analysis
IntroductionThe efficacy and safety of neurokinin-1 (NK-1) receptor antagonist in adults with cough remain unclear. Our objective was to systematically assess the efficacy and safety of NK-1 receptor antagonist for cough treatment using the latest available clinical evidence.MethodsA comprehensive…
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Artikel Jurnal
Public knowledge, safety perceptions, and use patterns of ashwagandha (Withania somnifera) among Saudi adults: a mixed-methods study
BackgroundWithania somnifera, commonly known as ashwagandha, is a widely used herbal remedy with reported anxiolytic and adaptogenic properties. Despite its growing use globally and regionally, comprehensive public understanding of its pharmacological benefits, safety, and potential risks remains…
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