31.912 hasil
Menampilkan 681–700 · 0,22 detik · RSS
-
Artikel Jurnal
Preclinical effects of naringin on bone outcomes in animal models of osteoporosis: a systematic review and meta-analysis
BackgroundNaringin, a flavanone glycoside derived from citrus plants and other botanical sources, has shown potential skeletal protective effects in preclinical studies. However, quantitative evidence regarding its effects across different osteoporosis models and skeletal outcomes remains…
-
Artikel Jurnal
Carvacrol exhibits potent anti-Klebsiella activity, whereas the multicomponent composition of essential oils may contribute to their enhanced antibacterial activity
Multidrug-resistant (MDR) Klebsiella infections represent an increasing therapeutic challenge, underscoring the need for complementary antimicrobial strategies. Essential oils (EOs) are complex mixtures of bioactive compounds, and their antibacterial effects may not be fully explained by their…
-
Artikel Jurnal
Total flavonoids of Desmodium styracifolium attenuate nephrolithiasis via reducing calcium oxalate crystallization and renal inflammation
IntroductionDesmodium styracifolium, known as Guangjinqiancao in Chinese, is a widely used traditional medicinal herb in Southern China for clearing heat and excreting dampness. It has been historically prescribed for the treatment of urological disorders, particularly urolithiasis (Shi Lin). While…
-
Artikel Jurnal
Scutellarin attenuates high glucose-induced edema and inflammation in retinal Müller cells via AQP4/Kir4.1 restoration and TLR4/MyD88/NF-κB inhibition
BackgroundDiabetic retinopathy (DR) is a metabolic eye disease closely linked to inflammation and oxidative stress, potentially causing vision decline or blindness. Scutellarin (SCU), a major flavonoid extracted from Erigeron breviscapus, possesses anti-inflammatory and antioxidant properties…
-
Artikel Jurnal
Early socially isolated rats of both sexes reduce alcohol consumption and seeking by the Galanin (1–15) and naltrexone combination
BackgroundAlcohol Use Disorder (AUD) is a psychiatric condition whose severity can be amplified by social factors, such as social isolation, particularly during adolescence, which exacerbates development of AUD in adulthood. Our previous studies have demonstrated that the Galanin (1–15) fragment…
-
Artikel Jurnal
Squalene alleviates DSS-induced colitis by restoring Nrf2-dependent redox balance and gut microbiota homeostasis
BackgroundUlcerative colitis (UC) is a chronic inflammatory disorder characterized by excessive oxidative stress, intestinal epithelial barrier dysfunction, and gut microbiota dysbiosis; despite expanding therapeutic options, achieving durable disease control remains challenging. Squalene (SQ), a…
-
Artikel Jurnal
Clinical research progress of esketamine in perioperative neuroprotection: from mechanisms to therapeutic neuroprotection
During the perioperative period, factors such as ischemia-reperfusion injury, neuroinflammation, and cognitive dysfunction not only significantly affect postoperative recovery, but also are the main causes of postoperative disability and perioperative death. Esketamine is the R-enantiomer of…
-
Artikel Jurnal
Integrating network analysis and machine learning to explore the pharmacological targets and associations of oleanolic acid in lung adenocarcinoma
BackgroundLung adenocarcinoma (LUAD), a major type of non-small cell lung cancer, has high incidence and mortality rates. Oleanolic acid (OA), a natural pentacyclic triterpene compound, has demonstrated potential anti-tumor effects but its pharmacological effects in LUAD remain unclear.PurposeThis…
-
Artikel Jurnal
A novel provocation protocol to identify nocebo effects in clinical practice—a proof-of-concept n-of-1 study
IntroductionNocebo effects, driven by negative expectations rather than pharmacological mechanisms, are an under-recognized cause of adverse effects in clinical practice. Although experimental studies have used expectation manipulation to explore these phenomena, translation into clinical…
-
Artikel Jurnal
Occurrence, variability and evolutionary relations of efflux pump determinants across five pathogenic Staphylococcus species
Multidrug efflux pumps (MDR EPs) play a major role in the emergence of antimicrobial resistance in Staphylococcus aureus. Among these, the native NorA is the most well-studied MDR EP in this species. However, efflux-mediated resistance is only scarcely characterized in other staphylococci. The aims…
-
Artikel Jurnal
SIRT7 upregulation protects against TKI-induced cardiotoxicity by inhibiting MCU-mediated mitochondrial calcium overload
BackgroundTyrosine kinase inhibitors (TKIs) are potent anticancer agents; however, their clinical application is often restricted because of cardiotoxic effects. The mechanisms underlying cardiotoxicity that are shared across different TKIs remain inadequately understood.PurposeThis study aimed to…
-
Artikel Jurnal
Microplastic exposure is associated with enhanced PI3K-Akt signaling in DSS-induced colitis: integrated bioinformatics analyses and in vivo validation
BackgroundMicroplastics (MPs) are widely distributed in the environment and may aggravate ulcerative colitis (UC), but the underlying molecular mechanisms remain unclear.MethodsWe integrated network toxicology, RNA-seq-based differential expression analysis, molecular docking, GeneMANIA-based…
-
Artikel Jurnal
Timing of nebulized colistimethate sodium following bronchodilator airway conditioning in hospital-acquired pneumonia: a target trial emulation study
BackgroundEvidence for nebulized colistimethate sodium (CMS) in hospital-acquired pneumonia (HAP) remains inconsistent, potentially due to heterogeneity in airway conditions and delivery timing. We evaluated whether timely initiation of nebulized CMS following bronchodilator airway pre-treatment…
-
Artikel Jurnal
Sodium nitrite reduces circulating asymmetric dimethylarginine in a reduced uterine perfusion pressure rat model of preeclampsia
IntroductionPreeclampsia (PE) is characterized by hypertension, endothelial dysfunction, and reduced nitric oxide (NO) bioavailability. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of endothelial NO synthase, is elevated in PE and contributes to vascular dysfunction. NO may regulate…
-
Artikel Jurnal
Celastrol ameliorates ulcerative colitis by inhibiting HSP90-mediated necroptosis of intestinal epithelial cells
IntroductionUlcerative colitis (UC) is a chronic inflammatory bowel disease characterized by intestinal barrier dysfunction and epithelial cell death. Necroptosis of intestinal epithelial cells (IECs) mediated by the RIPK1/RIPK3/MLKL pathway has emerged as a key driver of UC progression. Celastrol…
-
Artikel Jurnal
uPAR-directed immunotherapies in solid tumors: current advances and future perspectives
In cancer, elevated expression of the urokinase-type plasminogen activator receptor (uPAR) is a well-established adverse prognostic factor associated with enhanced tumor invasion, metastatic dissemination, cellular proliferation, and resistance to conventional therapies. Genetic ablation or…
-
Artikel Jurnal
Lipid metabolism as a cell-state determinant in pulmonary fibrosis: from epithelial failure to ferroptosis-driven amplification
Despite 2 decades of mechanistic progress, pulmonary fibrosis still progresses in many patients, and established scar rarely resolves. Lipid metabolism has emerged as a unifying lens on this disease, but a useful synthesis requires recognizing that the relevant abnormalities are…
-
Artikel Jurnal
Targeted delivery platforms for in vivo immune cell engineering: emerging strategies for cancer immunotherapy
Cancer immunotherapy is a transformative technology allowing for the elimination of malignant cells through immune system stimulation; however, the large-scale clinical application of adoptive cellular therapy technologies is limited due to difficulties in ex vivo immune cell engineering, high…
Menampilkan maksimal 50 halaman. Persempit pencarian dengan filter untuk hasil yang lebih spesifik.