31,912 results
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Journal Article
Calcium channel blocker-associated pulmonary toxicity: epidemiology, mechanisms, and clinical management
Calcium channel blockers are first-line medications for the treatment of hypertension, angina pectoris, and arrhythmias, and are generally well-tolerated. However, in recent years, there have been reports indicating that CCBs may cause severe pulmonary toxicity, such as non-cardiogenic pulmonary…
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Journal Article
Evaluating a large language model (ChatGPT-5) for detecting potential drug–drug interactions in intensive care: a cross-sectional comparative study with a clinical decision support system
Background/ObjectivesPolypharmacy in intensive care units (ICUs) substantially increases the risk of potential drug–drug interactions (pDDIs), which may lead to adverse drug events and worsen clinical outcomes. Conventional rule-based clinical decision support systems (CDSSs), although widely used…
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Journal Article
Indobufen-based dual antiplatelet therapy in patients undergoing PCI: a systematic review and meta-analysis
BackgroundConventional dual antiplatelet therapy (DAPT) post percutaneous coronary intervention (PCI) comprises aspirin and a P2Y12 inhibitor. However, aspirin increases gastrointestinal and bleeding risks. Indobufen, a reversible COX-1 inhibitor, may offer a safer alternative.ObjectivesTo evaluate…
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Journal Article
Ivermectin exposition during neurulation induces neural tube defects and neuromuscular alterations in Xenopus laevis through purinergic P2X4-signaling
BackgroundNeurulation is a fundamental process in the formation of the central nervous system (CNS). The process begins with the folding and fusion of the neural plate to form the neural tube which subsequently gives rise to the development of the brain and spinal cord. Environmental and genetic…
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Journal Article
Integrative proteomic and metabolomic analysis reveals that ouabain inhibits DLBCL proliferation by reprogramming arginine-driven metabolic networks
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma (NHL), with an increasing incidence in recent years. Ouabain, a cardiotonic steroid, has demonstrated anti-tumor effects in various cancers including DLBCL, but its mechanism of action is not yet fully…
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Journal Article
Review Areca Thirteen Pill (GY-13) for depression: a ConPhyMP-Informed critical review of material definition, pharmacological evidence, and translational Heyi-neuroplasticity-stress hypotheses
Previous summaries of GY-13 have lacked transparent literature-search methods, reproducible material definitions, chemical-characterization status, or critical evidence grading, limiting their scientific utility.ObjectiveThis review critically evaluates what the published GY-13 literature shows and…
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Journal Article
Hantavirus as a persistent zoonotic risk: epidemiology and current pharmacological management
BackgroundHantaviruses are emerging rodent-borne zoonotic viruses that continue to pose a public health concern despite their relatively low incidence in humans. The 2026 Andes virus outbreak linked to the MV Hondius cruise ship renewed international attention on these pathogens, highlighting…
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Journal Article
Elucidating the role of medicinal plants in melanoma treatment: a review on metastatic progression and phytochemical intervention
Metastatic melanoma remains one of the most highly aggressive and treatment-resistant cancers, highlighting the need for enhanced understanding of its progression and novel therapeutic strategies. The metastatic cascade is an intricate, dynamic, and coordinated series of events which initiates with…
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Journal Article
The crotonylation reader DPF2 promotes the development and progression of colon adenocarcinoma through cell-type-specific immune regulation and metabolic reprogramming
BackgroundThe crotonylation reader DPF2 has been implicated in tumor progression, but its role in colon adenocarcinoma (COAD), especially in cell-type-specific immune regulation and metabolic reprogramming, remains unclear.MethodsWe conducted an integrative multi-omics study combining genetic…
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Journal Article
Mechanism of BaP- regulated hepatic lipid metabolism via AhR activation and AR modulation
ObjectiveBenzo[a]pyrene (BaP) is a ubiquitous environmental pollutant that disturbs hepatic lipid metabolism. The androgen receptor (AR) protects hepatic lipid homeostasis, but whether BaP interferes with AR nuclear translocation through aryl hydrocarbon receptor (AhR) activation to cause metabolic…
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Journal Article
The abundance of gut bacterial families as an early marker of diet-induced metabolic shift: a study in young pre-obese rats and a hint to a potential prophylactic window
The occurrence of overweight-obesity in youth has increased globally, with growing evidence supporting the relevance of the gut microenvironment as a pathophysiological factor. The time preceding obesity consolidation is particularly relevant to therapeutic management; therefore, we evaluated gut…
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Journal Article
Experimental screening and structure-informed engineering of peptide-fused bacteriophage lysins with enhanced activity against Gram-negative bacteria
The increasing prevalence of antibiotic-resistant bacteria necessitates the development of novel antimicrobial strategies. Bacteriophage-derived lysins are promising options, but lysins against Gram-negative bacteria lose their activity under physiological conditions. Peptide fusion strategies have…
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Journal Article
Evaluation of a multi-component AI-guided mechanistic reasoning practical in experimental pharmacology: a single-group pre-post study
Background. Experimental pharmacology requires students to interpret laboratory findings, identify affected physiological pathways, and infer underlying drug mechanisms. While artificial intelligence (AI) is increasingly explored in health professions education, concerns remain regarding passive…
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Journal Article
Targeting heparanase-associated epithelial glycocalyx remodeling attenuates Akt/NF-κB–related barrier dysfunction in experimental COPD
BackgroundChronic obstructive pulmonary disease (COPD) is characterized by persistent airway inflammation, epithelial barrier dysfunction, and progressive structural remodeling. Although glycocalyx impairment has been implicated in COPD pathogenesis, the mechanisms linking glycocalyx degradation to…
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Journal Article
2′-deoxyinosine ameliorates multiple sclerosis through modulating Th1/Th2 and Th17/Treg cell balance with potential involvement of AMPK phosphorylation
BackgroundMultiple sclerosis (MS) is an autoimmune and neurodegenerative disease characterized by T lymphocyte infiltration and demyelination that can lead to severe disability without treatment. However, effective treatment for MS remains an unmet need. 2′-deoxyinosine (2′-DI), an endogenous…
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Journal Article
Combined Taraxacum mongolicum and Astragalus polysaccharides attenuate CCl4-induced hepatic fibrosis through modulation of the TLR4/MyD88/NF-κB signaling pathway and gut microbiota composition
BackgroundHepatic fibrosis represents a critical pathological stage in the progression of chronic liver diseases, yet clinically effective and low-toxicity therapeutic options remain limited. Taraxacum mongolicum and Astragalus form a classic hepatoprotective herbal pair, and their derived…
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Journal Article
High-throughput phenotypic screening identifies the phytochemical melissic acid that mitigates SHED cellular senescence via the ADCY5/cAMP/CREB axis
IntroductionCellular senescence drives aging and age-related diseases, posing a critical barrier to stem cell-based regeneration. While selective elimination of senescent cells (senolysis) remains a theoretically promising strategy, safe natural senotherapeutic agents are limited. Human exfoliated…
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Journal Article
Drug-induced hyperglycemia in obstetrics: key offending drugs, mechanisms, and practical management
IntroductionDrug-induced hyperglycemia is an important metabolic complication that may arise when medications disrupt insulin secretion, insulin sensitivity, or glucose homeostasis. In obstetric practice, several commonly used drugs, including glucocorticoids, progesterone, antihypertensive agents…
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