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Artikel Jurnal
Targeting DPP9 attenuates podocyte injury by regulating NRF2 antioxidant signaling
IntroductionPodocyte injury is a critical event in the progression of chronic kidney disease (CKD), with oxidative stress as a central pathogenic mechanism. Despite the efficacy of finerenone in mitigating CKD progression, its precise cytoprotective mechanisms within podocytes remain incompletely…
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Systematic review and meta-analysis of the antidepressant-like effects of ginsenosides in animal models: comparative behavioral profiles and exploratory dose-stratified analysis
ObjectivesThis study systematically evaluated the antidepressant-like effects of individual ginsenoside monomers and total ginsenosides in animal models of depression, compared pooled behavioral profiles across components, and summarized the principal mechanisms proposed in the included studies…
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Artikel Jurnal
Long-acting RNAi therapeutics in hypertension: limitations of single-target AGT silencing and rational multi-target synergistic strategies
Hypertension affects over 1.3 billion people worldwide, fewer than 20% achieve adequate blood pressure (BP) control. Poor long-term BP management accelerates irreversible damage to target organs, highlighting the urgent need for novel therapeutic approaches. Small interfering RNAs (siRNAs) are…
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Palmitoylation reprograms the intestinal mucosal barrier microenvironment: potential mechanisms and promising therapeutic targets
Homeostasis of the intestinal mucosal barrier microenvironment is contingent upon the coordinated interplay among mechanical, chemical, and immunological barriers. Recent studies have demonstrated that protein S-palmitoylation, a dynamic and reversible lipid modification, holistically reprograms…
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Artikel Jurnal
Case Report: Massive sustained-release valproate overdose with prolonged gastric tablet retention and partial pharmacobezoar formation managed by endoscopic removal and delayed extracorporeal therapy
BackgroundValproate poisoning is a potentially life-threatening condition that may result in central nervous system depression, hyperammonemia, metabolic disturbances, and multiorgan dysfunction. Management of massive sustained-release valproate overdose remains challenging because delayed…
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Dimethyl malonate suppresses succinate dehydrogenase to alleviate ischemia/reperfusion-induced acute lung injury
BackgroundIschemia/reperfusion (IR) injury is a pivotal contributor to acute lung injury (ALI) for which effective treatment options are currently lacking. Following ischemia, succinate accumulation and reoxidation by succinate dehydrogenase (SDH) during reperfusion induce excessive reactive oxygen…
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Artikel Jurnal
Icariside II protects against neuronal injury by modulating PI3K/AKT-dependent mitochondrial dynamics and apoptosis in Alzheimer’s disease models
IntroductionIcariside II (ICS II), a major bioactive flavonoid metabolite from Epimedium, has been reported to exert neuroprotective effects, but its role in regulating mitochondrial dysfunction-related neuronal injury in Alzheimer’s disease (AD) has not been fully clarified.MethodsIn this study…
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Artikel Jurnal
Cost-effectiveness of pembrolizumab plus weekly paclitaxel for PD-L1–positive platinum-resistant recurrent ovarian cancer in the United States and China
BackgroundPembrolizumab plus weekly paclitaxel, with or without bevacizumab, improves survival in programmed death ligand 1 (PD-L1)–positive platinum-resistant recurrent ovarian cancer, but its economic value remains uncertain. This study evaluated the cost-effectiveness of pembrolizumab plus…
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Artikel Jurnal
ADAM17 as a proteolytic rheostat linking inflammation, tissue repair, and failure of inflammatory resolution in liver injury and fibrosis
A disintegrin and metalloproteinase 17 (ADAM17) is a membrane-bound sheddase that regulates inflammatory signaling, tissue repair, and fibrotic remodeling by converting cell-surface proteins into soluble forms. Rather than viewing ADAM17 simply as a proinflammatory enzyme, this review frames it as…
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Rhenium(I) tricarbonyl complexes with 1,10-phenanthroline derivatives: potential anticancer agents for hepatocellular carcinoma
BackgroundHepatocellular carcinoma (HCC) is a highly lethal malignancy with limited therapeutic options for advanced disease, motivating the development of metal-based agents that can bypass resistance and improve tumor selectivity.PurposeThis study aimed to evaluate rhenium(I) tricarbonyl…
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Artikel Jurnal
Differential effects of nAChR modulators on impulsive action in a nicotine self-administration Go/No-Go task in rats
IntroductionTobacco use disorder is a chronic condition characterized by compulsive nicotine use, withdrawal, and relapse following abstinence. Impulsivity contributes to persistent nicotine use and poor cessation outcomes. This study examined whether nicotinic acetylcholine receptor (nAChR)…
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Case Report: zanidatamab-based regimen as a potential later-line therapeutic option in HER2-amplified metastatic colorectal cancer
BackgroundOverexpression human epidermal growth factor receptor 2 (HER-2) has been identified as a key oncogenic driver in metastatic colorectal cancer (mCRC), detected in between 2% and 5% of the overall mCRC population, with a higher prevalence identified in RAS/RAF/PI3KCA wild-type patients…
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Artikel Jurnal
Association of carvedilol with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study
ObjectiveTo evaluate the association between carvedilol use and mortality in patients with sepsis.MethodsAll adult critically ill patients with sepsis were retrospectively identified from the MIMIC-IV database. Patients who received carvedilol between sepsis diagnosis and Intensive Care Unit(ICU)…
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Artikel Jurnal
Curcumin alleviates diabetic encephalopathy by attenuating cerebral microvascular ferroptosis: involvement of KEAP1/Nrf2 signalling
BackgroundCerebral microvascular injury and ferroptosis are increasingly implicated in diabetic encephalopathy (DE). This study investigated whether curcumin (Cur) alleviates DE by attenuating cerebral microvascular ferroptosis and examined the involvement of KEAP1/Nrf2-related…
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Artikel Jurnal
3-hydroxyanthranilic acid suppresses colorectal cancer growth and enhances 5-fluorouracil sensitivity via the YY1-p53 and YY1-DKK4 axes
IntroductionThe tryptophan metabolite 3-hydroxyanthranilic acid (3-HAA) has been reported to exert tumor-growth-inhibitory activity; however, its functional role and underlying mechanisms in colorectal cancer (CRC) remain largely unexplored.MethodsWe measured 3-HAA levels in CRC tissues and…
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Intranasal dexmedetomidine for procedural sedation in preschool children aged 2–6 years undergoing emergency gastric lavage for acute poisoning: a propensity score-matched single-center retrospective cohort study
ObjectiveThis study aimed to evaluate the sedative efficacy and peri-procedural safety of preemptive intranasal dexmedetomidine in preschool children receiving emergency gastric lavage due to acute poisoning. Satisfactory procedural compliance rate was predefined as the primary efficacy outcome…
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Artikel Jurnal
Efficacy and safety of oxiracetam for cognitive and functional outcomes after acute traumatic brain injury in Chinese populations: a systematic review and meta-analysis of randomized controlled trials
BackgroundOxiracetam is used in China for cognitive dysfunction after traumatic brain injury (TBI), but its efficacy and safety remain uncertain. We assessed oxiracetam in adults with acute TBI.MethodsWe searched six bibliographic databases and trial registries from inception through 28 February…
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Artikel Jurnal
Renin–angiotensin system inhibitor use and survival outcomes in lung cancer: a systematic review and meta-analysis
BackgroundRenin-angiotensin system inhibitors (RASi) have been associated with favorable survival outcomes across various cancers, but their association with survival in lung cancer remains uncertain. We conducted a systematic review and meta-analysis to evaluate the association between RASi use…
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Artikel Jurnal
Isobavachalcone attenuates experimental periodontitis by suppressing PTGS2-associated macrophage ferroptosis and restoring periodontal immune homeostasis
BackgroundPeriodontitis (PD) is a destructive inflammatory disease driven by the collapse of immune homeostasis and alveolar bone resorption. Isobavachalcone (IBC) is a naturally occurring prenylated chalcone belonging to the plant flavonoid family, mainly enriched in the mature seeds of Cullen…
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Artikel Jurnal
Determinants of off-label drug acceptance in pregnancy: insights from an extended UTAUT model
BackgroundOff-label drug use (OLDU) is prevalent in obstetrics due to the scarcity of medications approved for pregnancy, raising potential risks and ethical challenges, particularly concerning informed consent. In this study, we aimed to identify the key determinants of OLDU acceptance among…
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