31,912 results
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Journal Article
The vegetable section of Běncaˇo Gāngmù: classification architecture, taxonomic logic, and nomenclatural practice
The Běncaˇo Gāngmù (Compendium of Materia Medica, 1596) by Lıˇ Shízhēn (1518–1593) introduced a five-class botanical classification and nomenclature system for its vegetable section (Cài Bù, volumes 26–28), replacing the three-grade quality hierarchy that had organized all earlier Chinese…
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Journal Article
The HO-1/bilirubin axis in cardiovascular protection: critical evidence for modulation by plant metabolites and traditional multi-component formulations used in Chinese medicine
Bilirubin was long regarded primarily as a waste product of haem catabolism, but accumulating experimental and epidemiological evidence suggests that, within an appropriate concentration range, it may contribute to cardiovascular protection through antioxidant, anti-inflammatory, endothelial…
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Journal Article
AI-guided ethnopharmacology for cardiovascular drug discovery: from biomedical data to experimental validation
Despite substantial advances in pharmacological therapy, cardiovascular disease remains the leading cause of mortality worldwide. Botanical drugs represent a rich source of structurally diverse bioactive metabolites, yet their translation into modern cardiovascular therapeutics remains limited by…
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Journal Article
Neuroprotective effects of rutin, sodium selenite, and rutin-conjugated selenium nanoparticles in a social isolation model
BackgroundSocial isolation (SI) is a long-standing experimental paradigm that models schizophrenia-like behavioural and neurobiological changes caused by the action of oxidative stress, neuroinflammation, apoptosis, and neurotransmitter imbalance. The scope of this paper was to comparatively assess…
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Journal Article
Predictive biomarkers for precision treatment in rheumatoid arthritis: are we there yet?
Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting approximately 1% of the global population and is associated with a substantial reduction in both life expectancy and quality of life. Although current treatments, primarily disease-modifying antirheumatic drugs, have been shown to…
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Journal Article
Sanguinarine ameliorates rheumatoid arthritis by activating the Hippo-YAP/TAZ pathway to induce apoptosis and suppress inflammation in fibroblast-like synoviocytes
IntroductionRheumatoid arthritis (RA) is a chronic autoimmune disease with progressive joint damage, functional disability and systemic comorbidity. Available therapies are not satisfactory, including low rates of remission and about 30% of patients with poor response to first-line treatment. Thus…
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Journal Article
Microbiota-based PBPK model: new approach methodology for assessing the kinetics of drugs and chemicals
Gut microbiota plays an important role in metabolising environmental chemicals and drugs. It affects the susceptibility of the host to toxicity by modifying metabolism, which can be captured by in-vitro assays and translated using in silico models. In-silico models like physiologically based…
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Journal Article
Case Report: Dasatinib-associated chylothorax and occult Bartonella henselae infection in pediatric leukemia: a case report and systematic review
Dasatinib is a second-generation tyrosine kinase inhibitor (TKI) used in Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL), and chylothorax is one of its rare but serious lymphatic complications. We encountered a 14-year-old boy with Ph + acute lymphoblastic leukemia (ALL)…
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Journal Article
Comparative efficacy of Traditional Chinese Medicine classical prescriptions for angina pectoris: a network meta-analysis
ObjectiveTo evaluate the efficacy and safety of classical prescriptions from Shang han Lun (Treatise on Febrile Diseases) and Jin gui Yao lue (Synopsis of the Golden Chamber) combined with conventional biomedicine in the treatment of angina pectoris of coronary heart disease.Materials and…
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Journal Article
Mechanistic insights into the potential role of botanical drugs and plant-derived metabolites in mitigating oxidative stress in varicocele
Varicocele (VC) is a prevalent male urogenital disorder associated with scrotal discomfort, impaired semen quality, and endocrine dysregulation, in which oxidative stress (OS) is repeatedly implicated as a key pathogenic axis linking venous stasis, hypoxia, hyperthermia, inflammation, mitochondrial…
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Journal Article
A smart MMP-9-responsive hydrogel releasing quercetin for psoriasis therapy
IntroductionPsoriasis is an autoimmune disease characterized primarily by chronic inflammation, with suboptimal clinical therapeutic outcomes. Quercetin, a bio-safe plant secondary metabolite, exerts anti‐inflammatory effects by modulating multiple signaling pathways and holds promise as a…
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Journal Article
Efficacy, mechanisms, and influence factors of small molecule targeted therapy in treating rheumatoid arthritis: a multi-dimensional clinical, immunological, and ultrasonographic study
BackgroundTargeted synthetic disease-modifying antirheumatic drugs (tsDMARDs) show promise for rheumatoid arthritis (RA), but multi-dimensional efficacy evaluation needs further study.ObjectiveThis study aimed to comprehensively assess tsDMARDs’ efficacy in RA and explore factors linked to…
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Journal Article
Efficacy and safety of lecanemab monoclonal antibody in the treatment of mild to moderate Alzheimer’s disease: a systematic review and meta-analysis
BackgroundLecanemab is a novel therapy for Alzheimer’s disease (AD), but comprehensive evidence is lacking. This systematic review and meta-analysis evaluated the efficacy and safety in AD.MethodsRegistered in PROSPERO (CRD420251146867). PubMed, Embase, Cochrane Library, Web of Science, and Scopus…
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Journal Article
Immune checkpoint inhibitors across neoadjuvant, perioperative, and adjuvant settings for resectable non-small-cell lung cancer: a systematic review and meta-analysis of randomized trials
BackgroundRandomized evidence for immune checkpoint inhibition in resectable non-small-cell lung cancer has progressed from pathological response to mature survival outcomes. We examined exploratory directional alignment across endpoints and quantified clinical yield, treatment burden, and the…
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Journal Article
Frequency, causes, and duration of drug shortages in South Korea, 2018–2024: a nationwide descriptive analysis of regulatory reporting data and temporal patterns across the COVID-19 pandemic
BackgroundDrug shortages threaten treatment continuity and health-system resilience, yet empirical evidence from South Korea remains limited.MethodsWe conducted a nationwide, retrospective descriptive analysis of 868 drug products (1,054 shortage reports) officially reported to the Ministry of Food…
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Journal Article
LKB1 promotes lung adenocarcinoma cell senescence by suppressing the O-GlcNAc glycosylation-mediated activation of telomerase
BackgroundTelomeres are crucial for maintaining genomic integrity and stability, making them promising anticancer therapy targets. O-GlcNAc glycosylation is unique and involved in most cellular functions. In most cancers, there is a positive correlation between the degree of tumor malignancy and…
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Journal Article
Emerging nanotechnological strategies for delivering bioactive components from botanical drugs and traditional Chinese medicine in atherosclerosis therapy: from formulation to mechanism
Atherosclerosis (AS), the primary pathological basis of global cardiovascular disease mortality, is undergoing a paradigm shift in treatment strategy, from risk factor management toward precise plaque intervention. Nano-formulations are a major research focus in pharmaceutics. The “nanoization” of…
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Journal Article
Platycodin D alleviates cardiac hypertrophy in the treatment of heart failure by inhibiting p53-dependent BCL-2/Bax/caspase-3 signaling pathway
IntroductionCardiac hypertrophy drives heart failure progression, with cardiomyocyte apoptosis playing a central role. Platycodin D (PLD), a bioactive saponin derived from Platycodon grandiflorum, exhibits cardioprotective properties, but its therapeutic potential and mechanisms in heart failure…
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Journal Article
Amanita muscaria in the evolving novel psychoactive substances landscape - toxicological risks and clinical implications: a narrative review
The rapid evolution of the novel psychoactive substances market has blurred the boundaries between synthetic “designer drugs” and other emerging psychoactive products distributed outside traditional regulatory frameworks. Recently, increasing recreational and self-therapeutic interest in Amanita…
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