31.912 hasil
Menampilkan 761–780 · 8,33 detik · RSS
-
Artikel Jurnal
Development of an adult whole-body PBPK model of irinotecan and its metabolites for predicting UGT1A1/CYP3A-mediated drug-drug interactions
BackgroundIrinotecan (CPT-11) is a prodrug that is bioactivated to SN-38, which is primarily cleared via UGT1A1-mediated glucuronidation. Its complex metabolism, which also involves CYP3A-mediated oxidation, makes irinotecan highly susceptible to enzyme-mediated drug-drug interactions (DDIs). This…
-
Artikel Jurnal
Triptolide clears Staphylococcus aureus infection by targeting XIAP to induce host apoptosis while maintaining gut microbiota homeostasis
BackgroundStaphylococcus aureus (SA) remains a global health threat due to its increasing drug resistance and intracellular persistence, which compromise the conventional antibiotic efficacy. Host-directed therapy (HDT) has emerged as a promising alternative by modulating host immunity. With…
-
Artikel Jurnal
Luteolin and neuroinflammation: a multi-target therapeutic strategy for central nervous system disorders
Neuroinflammation is a fundamental pathological hallmark driving the initiation and progression of various neurological disorders. Luteolin, a natural flavonoid abundant in medicinal plants, fruits, and vegetables, exerts multifaceted neuroprotective effects across diverse experimental disease…
-
Artikel Jurnal
Evaluating the association between intravenous immunoglobulin and thromboembolic events in patients with autoimmune diseases: a retrospective real-world study
BackgroundIntravenous immunoglobulin (IVIG), a cornerstone in the management of autoimmune diseases (ADs), entails a concerning risk of thromboembolic events (TEEs). Current risk-stratification models, however, suffer from a critical omission, as they do not include dynamic biomarkers such as…
-
Artikel Jurnal
Pharmacological effects of Salvia miltiorrhiza-derived interventions on osteoporosis in animal models: a systematic review and meta-analysis
PurposeThis systematic review and meta-analysis aimed to evaluate the pharmacological effects of Salvia miltiorrhiza-derived interventions, including extracts and bioactive metabolites, in treating osteoporosis in animal models.MethodsA comprehensive literature search was conducted across seven…
-
Artikel Jurnal
Melatonin suppresses abnormal hyperexcitability of hippocampal CA1 neurons in early-stage oxygen-glucose deprivation
Excitotoxicity in the early stages of ischemia is a primary trigger of neuronal injury. Literature has indicated the potential neuroprotective effects of melatonin against ischemic hypoxic injury, but the direct electrophysiological mechanisms underlying its regulation of neuronal excitability…
-
Artikel Jurnal
Comparative risk of arrhythmias associated with systemic antifungal agents: a disproportionality analysis of the FAERS database
ObjectiveThe real-world cardiac safety profile of systemic antifungal agents has not been thoroughly investigated. Based on the US Food and Drug Administration Adverse Event Reporting System FDA Adverse Event Reporting System database, this study analyzed the arrhythmogenic toxicity of nine…
-
Artikel Jurnal
Chronic simultaneous inducible nitric oxide synthase (iNOS) and peripheral cannabinoid CB1 receptors blockade ameliorates pulmonary hypertension in monocrotaline-induced rat model
BackgroundPulmonary arterial hypertension (PAH) is a severe multifactorial disease associated with impaired pulmonary hemodynamics, leading to right ventricular (RV) hypertrophy and failure. Induction of inducible nitric oxide synthase (iNOS) and/or activation of cannabinoid CB1 receptor (CB1R) is…
-
Artikel Jurnal
Multi-target mechanisms and therapeutic potential of Dahuang Zhechong pill in lower extremity peripheral artery disease: a structured narrative review
Lower extremity peripheral artery disease (PAD) is a chronic ischemic disorder primarily driven by atherosclerosis (AS) and characterized by endothelial injury, lipid deposition, inflammation, oxidative stress, and hemorheological abnormalities. From the perspective of traditional Chinese medicine…
-
Artikel Jurnal
Molecular mechanisms of polysaccharide components of kidney-tonifying traditional Chinese medicine in regulating osteoporosis
Osteoporosis, a prevalent systemic skeletal disorder, poses a significant health risk to the elderly population, arising from a multitude of factors that disrupt bone homeostasis. This delicate balance is primarily regulated by the dynamic interplay between osteoblasts and osteoclasts. When this…
-
Artikel Jurnal
Omega-3 polyunsaturated fatty acids are associated with microbiota-related 18β-glycyrrhetinic acid alterations and M2 macrophage polarization in type 1 diabetes mellitus
IntroductionOmega-3 polyunsaturated fatty acids (PUFAs) have been widely reported to exert beneficial effects in type 1 diabetes mellitus (T1DM). However, the mechanisms by which Omega-3 PUFAs influence pancreatic islet function through the gut-islet axis remain incompletely understood. This study…
-
Artikel Jurnal
Pharmacological mechanisms and clinical impacts of antidiabetic drugs on colorectal cancer risk: a systematic review
Type 2 diabetes mellitus (T2DM) significantly increases colorectal cancer (CRC) risk, driven by shared metabolic and inflammatory pathways. As lifelong glucose-lowering medications are routinely used in T2DM, their pharmacological activities and associated oncological effects have become critical…
-
Artikel Jurnal
Neutrophil extracellular traps contribute significantly to vascular dysfunction in sepsis
Sepsis is a systemic inflammatory condition triggered by severe infection, frequently resulting in multi-organ dysfunction. Vascular dysfunction, as its core pathological mechanism, involves a vicious cycle of inflammation, coagulation, and endothelial injury. The mechanism of vascular damage…
-
Artikel Jurnal
Hyper-inflammation and immunosuppression: redefining sepsis therapy using modern approaches
BackgroundSepsis is a life-threatening condition characterized by simultaneous hyperinflammation and immunosuppression, which leads to organ dysfunction and mortality. It is a global health concern, which is estimated to be approximately 166 million cases and 21.4 million global deaths in…
-
Artikel Jurnal
Clinodiside A, an active metabolite in Clinopodii herba, alleviates dextran-sulfate-sodium-induced ulcerative colitis
IntroductionClinodiside A is a natural bioactive component of Clinopodii herba, a genuine regional herb from Anhui Province (China) with multiple biological activities. This study aimed to explore the therapeutic potential of Clinodiside A in ulcerative colitis (UC).MethodsDextran sulfate sodium…
-
Artikel Jurnal
β-Caryophyllene protects against ischemic stroke by inhibiting H3K9 and H3K18 lactylation-mediated cellular pyroptosis
BackgroundIschemic stroke is a common and severe cerebrovascular disease with high mortality and disability. Accumulating evidence indicates that β-caryophyllene (BCP) exerts neuroprotective effects against cerebral ischemic injury; however, the precise underlying mechanisms remain largely…
-
Artikel Jurnal
GLP-1 receptor agonists in obesity-related knee osteoarthritis: from weight loss to therapeutic pathway reconstruction
Obesity is a major modifiable contributor to knee osteoarthritis (KOA), but excess adiposity has often been managed as a background risk factor rather than as a therapeutic target. In obesity-related KOA, adiposity may aggravate pain and disability through increased joint loading, low-grade…
-
Artikel Jurnal
Liquiritin restores metabolic homeostasis in NAFLD by modulating AKT1/FOXO1 signaling
BackgroundNon-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver condition with a complex and multifactorial pathogenesis.PurposeThis study aimed to investigate the mecha-nism of liquiritin (LQ) in NAFLD for its treatment.MethodsThis study integrates bioinformatics analysis with in…
-
Artikel Jurnal
Dose-dependent protective effects of theophylline on testicular endocrine function in a rat model of ischemia-reperfusion injury
IntroductionTesticular torsion (TT) induces ischemia–reperfusion (I/R) damage, frequently resulting in inflammatory responses, oxidative stress, and compromised spermatogenesis. This study investigated the potential therapeutic role of theophylline—a methylxanthine with established antioxidant and…
-
Artikel Jurnal
Lessons from the STOPPCog criteria: prevalence of potentially inappropriate medications for cognition and their association with a cognitive status - a cross-sectional study
IntroductionPotentially inappropriate medications (PIMs), are common among residents of long-term care institutions (LTCIs) and may contribute to cognitive impairment (CIm). STOPPCog criteria, developed in 2025, support the identification of PIMs relevant to cognition and accuracy of dementia…
Menampilkan maksimal 50 halaman. Persempit pencarian dengan filter untuk hasil yang lebih spesifik.