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Artikel Jurnal
Incidence and characteristics of eravacycline-associated increase in serum bilirubin levels: a retrospective study
ObjectivesTo compare the effects of eravacycline and tigecycline on serum bilirubin levels and investigate the incidence and clinical characteristics of total bilirubin increase associated with eravacycline.MethodsWe conducted a retrospective study in critically ill patients receiving eravacycline…
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Artikel Jurnal
Risk perception and influenza vaccine hesitancy among university students in Saudi Arabia
IntroductionUniversity campuses are high-risk environments for influenza transmission, yet vaccine coverage among students often remains suboptimal. This study aimed to identify the determinants of vaccine hesitancy among university students in Saudi Arabia using the Health Belief Model (HBM)…
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Artikel Jurnal
Clinical trial characteristics and intervention profiles for mild cognitive impairment: a systematic analysis of WHO ICTRP registry
IntroductionMild cognitive impairment (MCI) is a cognitive decline syndrome that represents an intermediate stage between normal aging and dementia, with a high risk of progression to dementia. The World Health Organization’s International Clinical Trials Registry Platform (WHO ICTRP) is the…
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Artikel Jurnal
Rivaroxaban versus warfarin: differential effects on oxidative stress and fibrinolytic markers in atrial fibrillation
BackgroundAtrial fibrillation (AF) is a cardiac arrhythmia characterized by disorganized atrial electrical activity, resulting in ineffective mechanical contraction and a heightened propensity for intra-atrial thrombus formation. The underlying pathophysiology is multifactorial, involving a complex…
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Artikel Jurnal
Urolithin A regulates gut: liver axis to ameliorate alcohol-associated liver disease
Background and AimsExcessive alcohol consumption poses a significant global health concern, ranking as the world’s third-largest risk factor for diseases and disabilities, contributing to 5.9% of all deaths worldwide. Among various disorders linked to alcohol misuse, alcohol-associated liver…
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Artikel Jurnal
Long-term nitric oxide exposure induces cough hypersensitivity via non-inflammatory activation of the HIF1α–TRPV1 pathway
BackgroundChronic cough hypersensitivity is common across respiratory diseases and often occurs without airway inflammation, yet effective treatments remain limited. Nitric oxide (NO), an important endogenous signaling molecule and environmental pollutant, has been implicated in respiratory…
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Artikel Jurnal
Comparative efficacy and safety of mesalazine-based regimens with traditional Chinese medicines in mild-to-moderate ulcerative colitis
BackgroundTraditional Chinese medicine (TCM) formulations are increasingly used in combination with mesalazine to treat mild-to-moderate active ulcerative colitis (UC). However, direct comparisons between various TCM regimens are limited.MethodsWe performed a frequentist network meta-analysis of 34…
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Artikel Jurnal
EMMPRIN deficiency alleviated metabolic-associated steatohepatitis progression via regulation of the UBA52–MCT1 axis
BackgroundMetabolic dysfunction-associated steatohepatitis (MASH) is characterized by a lipid overload-induced pathological cascade featuring hepatocyte injury, inflammation, and progressive fibrosis. This study aims to systematically investigate the role of EMMPRIN in MASH progression, and to…
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Artikel Jurnal
Silent inflammation: a hidden cause of liver fibrosis
Systemic inflammation induced by adipose tissue is common in obese individuals and is often overlooked due to its subclinical nature. The constant secretion of proinflammatory factors shifts the balance toward inflammation, affecting the body’s homeostasis and facilitating the development of…
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Artikel Jurnal
Multi-omics reveals the protective mechanisms of Gastrodia elata ethyl acetate extract in vascular dementia
ObjectiveThis study aimed to investigate the ameliorative effect of the ethyl acetate extract of Gastrodia elata (EEGE) on vascular dementia (VD) and its underlying mechanisms.MethodsA VD rat model was established using the two-vessel occlusion method, while an in vitro cerebral ischemia injury…
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Artikel Jurnal
Effects of Kang’ai injection combined with chemotherapy on immune function in advanced non-small cell lung cancer: a meta-analysis
BackgroundSystematically evaluate the effects of Kang’ai Injection (KAI) combined with platinum-based chemotherapy on immune function, clinical efficacy, and safety in patients with advanced non-small cell lung cancer.Materials and methodsRelevant literature published from the inception of each…
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Artikel Jurnal
Integrative multi-omics and experimental analyses implicate PTK2 as a lorazepam-associated biomarker and potential therapeutic target in ovarian cancer
BackgroundOvarian cancer remains one of the most lethal gynecologic malignancies, characterized by high recurrence rates and chemoresistance. Recent advances suggest that neuroactive drugs such as lorazepam may exert off-target molecular effects beyond the central nervous system. However, their…
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Artikel Jurnal
Development and characterization of a novel B7-H3 rabbit monoclonal antibody for glioma diagnosis
BackgroundGlioma is the most common primary brain tumor of the central nervous system and is associated with poor clinical outcomes, particularly in high‐grade diease. The immune checkpoint protein B7‐H3 (CD276) is significantly overexpressed in glioma and multiple other solid tumors, highlighting…
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Artikel Jurnal
Cerebrolysin, hemorrhagic transformation, and anticoagulation timing after reperfusion therapy in stroke: post hoc secondary analysis of the CEREHETIS trial
BackgroundThe optimal timing of anticoagulation resumption after acute ischemic stroke remains uncertain, particularly in patients at elevated risk of hemorrhagic transformation (HT). Although Cerebrolysin reduces HT incidence, its influence on dynamic HT risk and the safe anticoagulation window…
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Artikel Jurnal
Very low enalapril and enalaprilat exposure via human milk: a case report from the ConcePTION project
IntroductionOngoing maternal and clinical hesitancy in breastfeeding-related shared decision-making is driven by limited safety data on maternal pharmacotherapy. Theoretical exposure to maternal enalapril and its active metabolite enalaprilat in breastfed infants has previously been reported in two…
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Artikel Jurnal
Knowledge domain and evolutionary trends of P2Y receptors in cardiovascular diseases: a bibliometric and altmetric analysis
ObjectiveThis study employs a dual-metric framework integrating bibliometric and altmetric analyses to systematically map the knowledge domain and structural evolution of P2Y receptor research in cardiovascular diseases (CVDs) from 2005 to 2025.MethodsData were systematically retrieved from the Web…
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Artikel Jurnal
Mechanistic insights into Shenqi Dihuang decoction in the treatment of immunoglobulin a nephropathy
BackgroundImmunoglobulin A nephropathy (IgAN) is among the most prevalent glomerular disorders. Shenqi Dihuang decoction (SQD) has demonstrated therapeutic efficacy in various renal conditions, but its effects on IgAN remain insufficiently explored. The present investigation was designed to explore…
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Artikel Jurnal
Traditional herbal medicine for obesity-related polycystic ovary syndrome: a meta-analysis and data mining study
ObjectiveTo systematically evaluate the clinical efficacy of traditional herbal medicine (THM) as an adjunctive therapy for obesity-related polycystic ovary syndrome (PCOS) and to identify core botanical drug combinations using evidence synthesis and data mining approaches.MethodsWe searched six…
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Artikel Jurnal
The effect of plant active substances on cognitive function in healthy older adults: a systematic review and network meta-analysis of randomized controlled trials
BackgroundWith the accelerating global population aging, age-related cognitive decline has become a significant health concern for the older adults. The limited efficacy and common side effects of pharmacological interventions have made the exploration of safe non-pharmacological strategies an…
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