31,912 results
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Journal Article
Effects of the glucagon-like peptide-1 receptor agonist liraglutide on retinal endothelial function and oxidative stress during sepsis
PurposeTo test the hypothesis that the glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide improves retinal vascular function in mice with polymicrobial sepsis.MethodsThree groups of mice were studied. Two groups underwent cecal ligation and puncture to induce polymicrobial sepsis. One…
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Journal Article
Comparative cardiovascular outcomes of renin–angiotensin system inhibitors in patients receiving maintenance hemodialysis: a large real-world cohort study
BackgroundThe comparative cardiovascular effectiveness of different renin–angiotensin system (RAS) inhibitors in patients receiving maintenance hemodialysis remains uncertain, and current guideline recommendations largely assume therapeutic equivalence between angiotensin-converting enzyme…
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Journal Article
Glucosamine/platelet-rich plasma/bone marrow MSC–loaded GelMA hydrogel supports cartilage endplate repair in mice and is associated with reduced inflammation- and oxidative stress–related readouts
ObjectiveIn this study, we developed a gelatin methacryloyl (GelMA) hydrogel composite for the simultaneous delivery of glucosamine (GlcN), platelet-rich plasma (PRP), and bone marrow–derived mesenchymal stem cells (BMMSCs). We systematically investigated its effects on cartilage endplate (CEP)…
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Journal Article
Soyeom-Jetong mixture attenuates NLRP3 inflammasome-mediated inflammation
Background. Soyeom-Jetong (SJ) is a traditional East Asian polyherbal formulation composed of Paeonia lactiflora Pallas, Glycyrrhiza inflata Batal, and Corydalis yanhusuo W.T. Wang, traditionally used for treating inflammatory disorders. Given the central role of the NLRP3 inflammasome in…
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Journal Article
Zebrafish as a translational platform for investigating multi-organ pharmacological interactions of traditional Chinese medicine
The advancement of Traditional Chinese Medicine (TCM) requires model systems capable of dissecting its multi-component, multi-target pharmacology in a rapid and systematic manner. This review presents the zebrafish as a versatile in vivo pharmacological platform for modern TCM research, not merely…
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Journal Article
TRAF6 promotes pulmonary hypertension by enhancing K63-linked ubiquitination and activation of STAT3
BackgroundPulmonary hypertension (PH) is a severe, progressive pulmonary vascular disease characterized by a sustained elevation of pulmonary vascular resistance, in situ thrombosis, and progressive vascular remodeling, with limited therapeutic options. In the present study, we aimed to determine…
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Journal Article
Nanomaterial-enabled delivery of plant-derived bioactive metabolites for diabetic retinopathy: from evidence appraisal to preclinical translation
As a leading cause of preventable blindness globally, diabetic retinopathy (DR) requires innovative treatments beyond conventional anti-VEGF therapies, which face limitations in efficacy, administration burden, and multifactorial targeting. Plant-derived bioactive metabolites (e.g., quercetin…
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Journal Article
Exposure prediction and dose optimization of polymyxin B based on bayesian and machine learning
ObjectivesTo explore the application scenarios of maximum a posteriori Bayesian estimation (MAP-BE) and eXtreme Gradient Boosting (XGBoost) in the prediction of polymyxin B (PMB) exposure.MethodsTwo sets of simulations based on the population pharmacokinetic (PopPK) model developed for PMB were…
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Journal Article
Xinnaoxin tablets ameliorate high-altitude polycythemia-associated cardiac injury by regulating the NF-κB, MAPK, and PI3K/AKT signaling pathways
Background and ObjectiveHigh-altitude polycythemia (HAPC) and its associated cardiac complications, induced by hypobaric hypoxia (HH), pose significant clinical challenges. Xinnaoxin (XNX) tablets are clinically utilized for these conditions; however, their integrated multi-target mechanisms remain…
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Journal Article
From intracellular processing to renal phenotypes: a mechanism-informed framework for interpreting kidney injury and electrolyte patterns with antibody–drug conjugates in solid tumors
BackgroundAntibody–drug conjugates (ADCs) have transformed solid-tumor therapy and are increasingly benchmarked directly against physician’s-choice chemotherapy. However, kidney adverse events and electrolyte disturbances remain inconsistently captured across trials and are often interpreted…
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Journal Article
Activation of Nrf2 signaling and suppression of oxidative stress-induced neuronal apoptosis: mechanisms for baicalin capsules relieving diabetic encephalopathy
IntroductionBaicalin is the most abundant flavonoid in the traditional Chinese heat-clearing botanical drug Scutellaria baicalensis Georgi. and has been demonstrated to exert a protective role in various brain diseases. Baicalin capsules (BC), a preparation composed primarily of baicalin, have been…
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Journal Article
Sirolimus excretion in breast milk: a preliminary investigation
BackgroundSirolimus is a mammalian target of rapamycin inhibitor that has been used in solid organ transplantation and is now increasingly being administrated to treat various manifestations of Tuberous Sclerosis (TSC). Lack of data regarding its safety during breastfeeding has led to its…
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Journal Article
Post-marketing safety surveillance and signal characterization of the novel dissociative steroid Vamorolone in Duchenne muscular dystrophy: a comparative disproportionality analysis based on FAERS data
ObjectiveTo comprehensively evaluate the real-world post-marketing safety profile of the novel dissociative steroid Vamorolone and perform a comparative analysis against the traditional glucocorticoid deflazacort.MethodsVamorolone-associated adverse event reports were extracted from the FAERS…
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Journal Article
Study on the anti-inflammatory effects and mechanisms of gentisic acid based on the LPS-induced RAW264.7 cell inflammation model and the oxazolone-induced zebrafish inflammation model
BackgroundGentisic acid (GA), a natural polyphenolic compound, possesses significant anti-inflammatory activity, but its molecular mechanism, particularly its association with the intestinal microbiota and specific signaling pathways, remains unclear.PurposeIn this study, we aimed to clarify…
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Journal Article
Antagonism of β-klotho signaling by peptide 19 impairs wheel running in male mice and potentiates the cisplatin-induced decrease in wheel running
BackgroundCancer-related fatigue results from competition between the metabolic demands of the tumor and those of skeletal muscles. This competition leads to an energy metabolism deficit, which is worsened by the detrimental effects of cancer therapy on mitochondrial function. Mitokines, such as…
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