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Artikel Jurnal
The role of pharmacists in quality management of venous thromboembolism: a retrospective, observational, single-center study in the cardiothoracic surgery department
BackgroundVenous thromboembolism (VTE) prophylaxis frequently falls short of ideal standards in current clinical practice. Based on China’s policy-oriented quality evaluation indicators for VTE management, this study explored the role of pharmacists in VTE prophylaxis quality management and…
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Artikel Jurnal
Wulingsan alleviates cisplatin-induced acute kidney injury and inhibits renal tubular epithelial cell apoptosis in association with the CaSR/CaMKKβ/AMPK pathway
IntroductionThe calcium-sensing receptor (CaSR), a G protein-coupled receptor (GPCR), plays a critical role in kidney injury by promoting inflammation and apoptosis when activated. Whether Wulingsan (WLS), a traditional Chinese herbal formula used for kidney disorders, exerts its protective effects…
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Artikel Jurnal
Regulation of doxorubicin resistance and cellular metabolism by miR-203a-3p via p53 and TAp63 signaling in hepatocellular carcinoma
Doxorubicin (DOX) is a cornerstone chemotherapeutic drug in the treatment of hepatocellular carcinoma (HCC). However, its efficacy is often limited by the development of drug resistance linked to increased cellular capacity to repair DNA damage. Altered tumor metabolism allows cancer cells to meet…
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Artikel Jurnal
Modulation of NF-κB and cytokine signaling by Cordia dichotoma and Cordia myxa attenuates methotrexate-induced pulmonary inflammation and oxidative injury in rats
BackgroundMethotrexate (MTX) is a widely used anticancer and immunosuppressive agent, but its clinical use is limited by lung injury associated with oxidative stress, inflammation, and fibrosis. Leaves of Cordia dichotoma and Cordia myxa traditionally have been used for respiratory disorders…
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Artikel Jurnal
Pharmacist-led management of suspected drug-provoked seizures and sequential antiseizure medication adverse reactions: a case report
BackgroundDrug-provoked seizures constitute a clinically significant yet frequently underappreciated complication of pharmacotherapy, particularly among patients receiving antimicrobial agents with established seizurogenic potential. The subsequent management of sequential adverse drug reactions…
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Artikel Jurnal
Impact of the national centralized volume-based procurement policy on antihypertensive drug procurement, price, and volume in Guangxi: an interrupted time series analysis of procurement data
IntroductionThe impact of China’s national centralized volume-based procurement (NVBP) policy on antihypertensive drug procurement in underdeveloped, multi-ethnic regions remains understudied. This study evaluated changes in procurement prices, volumes, and costs for four antihypertensive drugs…
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Artikel Jurnal
The potential role of lily polysaccharide in mitigating radiation-induced pneumonitis via the gut-lung axis: a comprehensive review
Radiation-induced pneumonitis (RIP) is a common and severe complication of thoracic irradiation, for which effective clinical treatments remain limited. Lily polysaccharide (LP), a natural polysaccharide derived from Lilium bulbs, exhibits various biological activities, including anti-inflammatory…
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Artikel Jurnal
Circadian rhythm disruption impairs time-dependent dentine regeneration and reprograms the late-stage dental proteome in a mouse pulp injury model
Circadian rhythms coordinate metabolic and regenerative programs, yet their contribution to pulp healing and tertiary dentinogenesis remains unclear. Here, we investigated whether chronic circadian rhythm disruption (CRD) alters time-dependent dentine repair and proteomic remodeling after dental…
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Artikel Jurnal
Complement-targeted therapies for transplant-associated thrombotic microangiopathy: recent advances
Transplant-associated thrombotic microangiopathy (TA-TMA) is a life-threatening complication of hematopoietic stem cell transplantation in which systemic complement activation induces endothelial injury, leading to microangiopathic hemolytic anemia, thrombocytopenia, and organ dysfunction. TA-TMA…
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Artikel Jurnal
Knowledge, attitudes, and practices of community pharmacists regarding the management of diabetes during Ramadan in the Aseer Region, Saudi Arabia
BackgroundFasting during Ramadan causes challenges for diabetes treatment, necessitating tailored counseling and adjustments for medication. Community pharmacists play a vital role in enhancing fasting safety, although their readiness has not been well investigated in southern Saudi Arabia. This…
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Artikel Jurnal
Safety and efficacy of the MNK/VEGFR inhibitor JDB153 combined with the anti-PD-1 antibody serplulimab in patients with advanced pancreatic cancer refractory to standard treatment: a single-arm, phase Ib/II study protocol
IntroductionPancreatic cancer remains a leading cause of death with poor prognosis. Current standard chemotherapies offer limited survival benefits, and no standard treatment exists for patients failing two lines of therapy. Preclinical evidence suggests that targeting MNK and VEGFR pathways can…
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Artikel Jurnal
A two-phase randomized study of oliceridine versus sufentanil for gastrointestinal endoscopy
BackgroundOliceridine is a novel G protein-biased μ-opioid receptor (MOR) agonist. It provides analgesic effects and reduces opioid-related adverse events (ORAEs). It has shown good efficacy in acute pain management. However, compared with traditional opioids, its optimal dosage and safety in…
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Artikel Jurnal
Targeting PTP4A3 with KVX-053 mitigates alcohol-amplified SARS-CoV-2 spike protein–induced acute lung injury
IntroductionChronic alcohol exposure is associated with increased vulnerability to acute respiratory distress syndrome (ARDS), and emerging evidence suggests that this susceptibility extends to the severe respiratory manifestations of COVID- 19. The SARS-CoV-2 Spike Protein S1 subunit (S1SP) can…
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Artikel Jurnal
A decade of clinical trials in Italy (2016–2025): trends, regulatory transformation and biotechnological evolution
IntroductionItaly represents one of major hubs for clinical research in Europe, nevertheless comprehensive long-term analyses of its clinical trial landscape under evolving regulatory frameworks remain limited. This study examines the trends of clinical trials submitted to the Italian Medicines…
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Artikel Jurnal
Long-term efficacy and safety of solifenacin, mirabegron, and their combination for overactive bladder: a systematic review
BackgroundCurrent clinical guidelines recommend either muscarinic receptor antagonists or β3-adrenoceptor agonists for overactive bladder (OAB) treatment. These recommendations, however, are primarily based on short-term (12-week) clinical trials, leaving a critical gap in evidence regarding their…
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Artikel Jurnal
Modified sini powder for the management of postoperative depression in non-small cell lung cancer patients: a multicenter, randomized, double-blind, placebo-controlled trial protocol
BackgroundPostoperative depression is a common complication following non-small cell lung cancer (NSCLC) resection, which adversely affects quality of life and may impede long-term survival. Modified Sini Powder (MSNP), a modified traditional Chinese medicine formula derived from classical Sini…
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Artikel Jurnal
Integrative management of gastric cardia cancer and precancerous lesions: prospects and mechanistic rationale for Banxia Xiexin Tang
Gastric cardia cancer is a biologically heterogeneous malignancy arising at the gastroesophageal junction that is, the upper opening of the stomach rather than the heart. It develops along an inflammation-metaplasia-dysplasia-carcinoma sequence and remains clinically challenging because early…
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Artikel Jurnal
Chronic inhibition of receptor protein tyrosine phosphatase β/ζ reduces amyloid plaque load and modulates pleiotrophin-expressing glial cells, glial-plaque interactions and genes related to amyloid beta clearance
Alzheimer’s disease (AD) is the most common cause of dementia. Pleiotrophin (PTN) is a neurotrophic factor relevant for central nervous system repair, neuron differentiation and survival. It is upregulated in different neuroinflammatory conditions. PTN is an endogenous inhibitor of Receptor Protein…
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Artikel Jurnal
Real-world pharmacovigilance of drug-related bone metabolism disorders: integrating FAERS and VigiAccess with a Bradford Hill-based causal plausibility assessment
BackgroundMetabolic bone diseases (MBDs) are a group of conditions characterized by imbalanced bone remodeling, including osteoporosis, osteomalacia, and rickets. In recent years, drug-induced secondary MBDs have emerged as a major clinical concern. However, systematic drug risk assessment studies…
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Artikel Jurnal
Transporter gene variants influencing metformin pharmacokinetics and pharmacodynamics common in European populations: a pharmacogenetic narrative review
Metformin is a widely used drug with a relatively good efficacy in diabetes treatment, a good safety profile, and the potential for use in other indications. The variability in the individual responses to metformin therapy is partially determined by genetic factors. This narrative review aimed to…
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