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Artikel Jurnal
Artificial cerebrospinal fluid preserves neuronal viability and attenuates apoptosis and oxidative stress in HT22 cells
IntroductionArtificial cerebrospinal fluid (ACSF) is critical for maintaining neuronal function during surgical procedures, yet its specific neuroprotective advantages over commonly used irrigation solutions like physiological saline and phosphate-buffered saline (PBS) remain unclear.MethodsThis…
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Morusin targeting GDF15 enhances ferroptosis and overcomes cisplatin resistance in NSCLC
BackgroundThe natural compound morusin (Mor) acts as a potent tumor suppressor in non-small cell lung cancer (NSCLC), but its potential to sensitize DDP and its direct targets are less understood. This work aims to investigate the DDP-sensitizing effects of Mor and the underlying…
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Hepatoprotective effects of astaxanthin and kokum on lipid peroxidation and fatty acid profile in mice with diet-induced NAFLD
IntroductionAmong adults, there is a constant increase in the incidence of non-alcoholic fatty liver disease (NAFLD). The significant limitations of available pharmacological therapies for this condition have led to intensive research into natural bioactive compounds with hepatoprotective…
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Applying molecular dynamics simulations to validate OCT1 substrates uncovers vitamin K1 as a high-affinity ligand
OCT1 is a hepatic membrane uptake transporter of clinical importance in drug metabolism and pharmacokinetics. OCT1 exhibits broad substrate specificity, mediating uptake of diverse compounds, including the neurotransmitter serotonin and the antidiabetic drug metformin. Numerous compounds have been…
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Voriconazole therapeutic drug monitoring and safety in HIV-infected patients with invasive fungal disease
ObjectiveTo characterize the distribution of voriconazole (VRC) trough concentrations (Ctrough), identify factors associated with VRC exposure in HIV-infected patients complicated by invasive fungal disease (IFD), and determine the Ctrough threshold associated with an increased risk of adverse drug…
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Cepharanthine improves blood glucose levels and mitigates renal injury in streptozotocin-induced diabetic rats via restoring pancreatic β-cell integrity and reducing inflammation
Background/ObjectivesWe have previously demonstrated that the natural alkaloid Cepharanthine (Ceph) reduces renal injury in streptozotocin (STZ)-induced insulin-deficient diabetic rats via antioxidant and anti-inflammatory mechanisms. However, the hypoglycemic mechanism of Ceph remains unclear. We…
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Artikel Jurnal
Decoding chemotherapy-induced peripheral neuropathy: ion channels, disease models, and future directions
Chemotherapy-induced peripheral neuropathy (CIPN) is a significant side effect of cancer treatments like paclitaxel and oxaliplatin, impacting patient quality of life (QoL). Despite much research, its underlying mechanisms remain unclear and effective therapies are lacking. This review evaluates…
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Artikel Jurnal
Meta-analysis of plant-derived exosome-like nanoparticles for the treatment of ulcerative colitis: efficacy and mechanisms insights
BackgroundPlant-Derived Exosome-Like nanoparticles (PELNs) are vital bioactive vesicles from medicinal plants, containing protective flavonoids, polyphenols, alkaloids, terpenoids, saponins, polysaccharides, and microRNAs. These compounds play crucial roles in PELNs’ anti-inflammatory and other…
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Artikel Jurnal
Bisphenols-enhanced platelet aggregation via TP, P2Y12, PAR1 and PAR4 receptors: a thrombotic legacy in a plastic-ubiquitous world
BackgroundCardiovascular diseases remain an urgent global health concern addressed by multiple clinical guidelines. Atherothrombosis is characterised by thrombus formation following disruption of atherosclerotic plaque, leading to major adverse cardiovascular events, such as myocardial infarction…
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Aconitum carmichaelii: a clinical-regulatory synthesis of traditional use, toxicological evidence, and global safety governance
Aconitum carmichaelii Debeaux (Ranunculaceae), commonly used as Aconiti Lateralis Radix Praeparata (Fuzi), is a clinically important but highly toxic herb in traditional Chinese medicine. Despite long-standing use for cardiovascular, rheumatologic, gastrointestinal, and pain-related conditions, its…
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Artikel Jurnal
Real-world pharmacovigilance analysis of the association between multiple sclerosis disease-modifying therapies and intervertebral disc herniation
BackgroundThis study aims to investigate the potential association between 13 disease-modifying immunosuppressive drugs used to treat multiple sclerosis and intervertebral disc herniation, thereby filling a gap in pharmacovigilance research in this field.Materials and methodsWe extracted adverse…
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Enhancing diabetes treatment by targeted nucleic acid and drug delivery using cell-penetrating peptides, peptide nucleic acids, and receptor targeting
Precise regulation of gene expression and drug delivery is required to maximize therapeutic efficacy and minimize adverse side effects. Several studies indicate a potential role for targeted gene and drug delivery in the precision therapy of type 2 diabetes and other diseases. This review…
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Artikel Jurnal
Risk factors for Post-PCI cardiovascular events in coronary artery disease patients treated with clopidogrel combined with aspirin
BackgroundCytochrome P450 family two subfamily C member 19 (CYP2C19) loss-of-function (LOF) variants may influence clopidogrel response after percutaneous coronary intervention (PCI), but their prognostic relevance within combined clinical and procedural risk assessment remains incompletely…
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Phytochemical properties of Curcuma caesia Roxb. improve sperm quality, testosterone levels, and testicular histology in male mice
BackgroundMedicinal plants used in traditional systems of medicine are a valuable source of bioactive compounds with therapeutic potential against oxidative stress–related disorders, including male infertility. Curcuma caesia Roxb. is an ethnomedicinally important species known for its antioxidant…
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Artikel Jurnal
Awareness, attitudes, and self-reported clinical management of antimicrobial-associated neurocognitive adverse effects among healthcare providers in Saudi Arabia
BackgroundAntimicrobials are among the most frequently prescribed medications worldwide, yet their neurocognitive adverse effects remain underrecognized. The adverse effects range from mild symptoms to serious effects and unrecognized adverse effects may influence prescribing behaviors and…
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Artikel Jurnal
The role of mitochondria in the gut-kidney axis: implications for kidney health
Mitochondria, multifunctional organelles that regulate cellular energy metabolism and signaling pathways, play a pivotal role in maintaining the physiological functions of the gut and kidneys, as well as influencing the progression of chronic kidney disease (CKD). Through the gut-kidney crosstalk…
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HER2-mutated lung squamous cell carcinoma responding to trastuzumab deruxtecan followed by pyrotinib: a Case Report
IntroductionHER2 (ERBB2) alterations are recognized oncogenic drivers in non-small cell lung cancer, but they are uncommon and poorly characterized in lung squamous cell carcinoma (LSCC).Case PresentationWe report a patient with initially resected stage IA2 LSCC who subsequently developed…
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Artikel Jurnal
Natural products reshape osteosarcoma cell fate: promoting cell death
Osteosarcoma is the most prevalent primary malignant bone tumor in children and adolescents. Despite advancements in adjuvant chemotherapy and surgical techniques, the overall survival rate of osteosarcoma patients remains suboptimal, particularly in cases of metastatic or recurrent disease…
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Artikel Jurnal
Reversal of ABCG2-mediated MDR by VEGFR3 inhibitor (S)-SAR131675
Multidrug resistance (MDR) remains a major challenge in cancer treatment, as it is a significant factor contributing to chemotherapy failure and cancer recurrence. Among various resistance mechanisms, the overexpression of the breast cancer resistance protein (BCRP/ABCG2) has been identified as a…
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Artikel Jurnal
Durable responses to long-term selumetinib in Chinese pediatric NF1 patients with inoperable plexiform neurofibromas
BackgroundThis study provides the first long-term efficacy and safety data of selumetinib in Chinese pediatric patients with inoperable symptomatic plexiform neurofibromas (PN) associated with neurofibromatosis type 1 (NF1).MethodsIn this single-center Phase I clinical trial(NCT04590235), we…
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