31.912 hasil
Menampilkan 841–860 · 0,52 detik · RSS
-
Artikel Jurnal
Low-dose dasatinib in second-line therapy or beyond for the treatment of chronic-phase chronic myeloid leukemia: a real-world cohort study
BackgroundDasatinib is a favorable option for patients with chronic-phase chronic myeloid leukemia (CML-CP) who have an inadequate response, treatment intolerance, or are attempting treatment-free remission (TFR). Dasatinib dose reduction is a strategy to improve tolerability while maintaining…
-
Artikel Jurnal
Use of analgesics during pregnancy: patterns of use and knowledge of medication safety among women in Serbia
BackgroundAnalgesics are commonly used during pregnancy, and their safe use depends on the type of drug, timing of exposure, and appropriateness of use. This study assessed patterns of analgesic use before and during pregnancy and evaluated women’s knowledge and perceptions regarding analgesic…
-
Artikel Jurnal
Differential recovery of ventricular repolarization and hemodynamics following bupivacaine and ropivacaine intoxication: the impact of lipophilicity on lipid emulsion efficacy
IntroductionLocal anesthetic systemic toxicity (LAST) causes significant ventricular repolarization disturbances. While intravenous lipid emulsion (ILE) is the standard treatment, the factors governing the simultaneous recovery of electrical and mechanical functions remain unclear. We evaluated ILE…
-
Artikel Jurnal
Periostin in allergic rhinitis: from pathogenic mediator to predictive biomarker and therapeutic target
Allergic rhinitis (AR) is a common disease around the world, mediated by type 2 immune responses, and some patients don’t respond well to current standard treatments. This shows AR isn’t a single type of disease but a complex syndrome caused by different internal body mechanisms. Periostin is a key…
-
Artikel Jurnal
Choline supplementation protects against sepsis-induced lung injury, potentially through suppression of Prtn3-associated monocyte activation
ObjectiveCholine supplementation has been implicated in the regulation of inflammation and immune responses. This study aimed to investigate the protective effects of choline supplementation in sepsis-induced lung injury (SLI) and to elucidate the underlying mechanisms.MethodsSLI was induced in…
-
Artikel Jurnal
The effectiveness and safety of commercial Chinese polyherbal preparation in treating infantile anorexia: a systematic review and Bayesian network meta-analysis
ObjectiveCommercial Chinese polyherbal preparations (CCPPs) are increasingly used for infantile anorexia (IA), but comparative effectiveness and safety differences among them remain unclear. This Bayesian network meta-analysis compares various CCPPs for IA to inform clinical practice.MethodsWe…
-
Artikel Jurnal
Leonurus japonicus Houtt. extract containing isoquercitrin reduces airway inflammation in mice with allergic asthma
BackgroundLeonurus japonicus Houtt. (Lamiaceae) has traditionally been used to treat respiratory disorders, including cough and dyspnea. The aim of this study was to investigate the therapeutic potential of a standardized hydroalcoholic extract from the aerial parts of L. japonicus in an in vivo…
-
Artikel Jurnal
Efficacy and safety of incretin-based therapies in patients with type 2 diabetes mellitus: a network meta-analysis based on clinical trials
ObjectivesThis study systematically assessed the efficacy and safety of 15 incretin-based therapies (IBTs) for type 2 diabetes mellitus (T2DM), including mono- (GLP-1RA), dual- (GIP/GLP-1RA or GLP-1/GCGR), and triple- (GIP/GLP-1/GCGR) receptor agonists, and explored how dosage and treatment…
-
Artikel Jurnal
The tryptanthrin derivative g2 suppresses tongue squamous cell carcinoma via PI3K/AKT/P53 cathway modulation: evidence from in vitro and in vivo studies
IntroductionTongue squamous cell carcinoma (TSCC) is a prevalent and aggressive oral malignancy with a poor prognosis and limited treatment options, underscoring the need for novel therapeutic agents. Tryptanthrin derivatives have shown promising anticancer potential across various cancers. This…
-
Artikel Jurnal
Safety, tolerability, pharmacokinetics, pharmacodynamics, and immunogenicity of STSA-1002, recombinant anti-human C5a fully human monoclonal antibody, in a randomized, first-in-human phase I study in healthy adults
STSA-1002 is a fully human monoclonal antibody targeting C5a, which plays a critical role in the pathogenesis of virus-induced acute respiratory distress syndrome ARDS (v-ARDS). We investigated safety, pharmacokinetics, pharmacodynamics, and anti-drug antibodies of increasing multiple intravenous…
-
Artikel Jurnal
Case Report: Is it COPD? It is Fabry disease: a case in which bronchodilators were briefly used but not continued, prioritizing enzyme replacement therapy
BackgroundFabry disease, an X-linked lysosomal storage disorder, can present with mixed ventilatory dysfunction on pulmonary function testing. In patients with a smoking history, this finding may trigger a reflexive consideration of COPD and unnecessary bronchodilator use. We report a case where…
-
Artikel Jurnal
The hypoglycemic metabolites and potential mechanisms of Lilium lancifolium (Juandan lily)
In Chinese folk medicine, lily bulbs have traditionally been used to help lower blood glucose levels. Numerous studies have demonstrated that extracts from lily bulbs possess significant hypoglycemic activity. However, the specific active metabolites and their underlying mechanisms remain unclear…
-
Artikel Jurnal
Galactagogue activity of shalukam (Nelumbium speciosum Willd rhizome) compared to domperidone in Wistar albino rats
Breast milk insufficiency is a significant public health concern, as it directly affects infant nutrition and immunity. Inadequate milk production remains a major barrier to effective breastfeeding, and it is reported in approximately 60 -90% of mothers in low- and middle-income countries…
-
Artikel Jurnal
Multidimensional targeting of ischemia-reperfusion injury by genistein: from molecular crosstalk to clinical translation
Ischemia-reperfusion injury (IRI) is a convergent pathology driven by oxidative stress, sterile inflammation, mitochondrial dysfunction, and regulated cell death (apoptosis, necroptosis, pyroptosis, ferroptosis), yet validated pharmacotherapies remain scarce. Genistein, a soy-derived isoflavone…
-
Artikel Jurnal
Advances in the treatment of Alzheimer’s disease
Alzheimer’s Disease (AD) is a progressive neurodegenerative disease for which disease-modifying therapies remain limited. Despite extensive efforts targeting amyloid-β and tau, these approaches have not translated into clear clinical benefit, underscoring the need for a more integrated…
-
Artikel Jurnal
Comparing the effects of propofol and sevoflurane anesthesia on cognitive dysfunction in elderly patients after abdominal surgery: a systematic review and meta-analysis of randomised controlled trials
ObjectivesTo conduct a systematic review and comparison of the effects of propofol and sevoflurane anesthesia on cognitive dysfunction in elderly patients following abdominal surgery.MethodsComparative studies published in PubMed, Web of Science, EBSCOhost, Cochrane Library, EMBASE, and Medline…
-
Artikel Jurnal
Association of blood-activating commercial Chinese polyherbal preparation with clinical outcomes in older patients with ischemic cardiovascular or cerebrovascular diseases: a real-world cohort study
BackgroundCommercial Chinese polyherbal preparation for activating blood and resolving stasis (CPABRS) were widely used in combination with guideline-directed antiplatelet agents (AA). However, real-world evidence on the effectiveness and safety of this combination remains limited, particularly…
-
Artikel Jurnal
Comparative efficacy of botulinum toxin and surgical treatment for acute acquired concomitant esotropia: a systematic review and meta-analysis
ObjectivesThis meta-analysis aimed to compare the efficacy of botulinum toxin (BTX) injection versus surgery for acute acquired concomitant esotropia (AACE).MethodsPubMed, Embase, Web of Science, China Biomedical Sinomed, and the Cochrane Library were systematically searched for studies comparing…
-
Artikel Jurnal
Integrative network pharmacology, molecular dynamics simulation, and single-cell RNA sequencing strategies reveal the multi-target mechanisms of oridonin against cervical cancer
IntroductionCervical cancer remains a major threat to women’s health worldwide, and effective therapeutic strategies with clear molecular mechanisms are still needed. Oridonin (Ori), a natural diterpenoid compound, has shown antitumor activity in multiple malignancies; however, its regulatory…
Menampilkan maksimal 50 halaman. Persempit pencarian dengan filter untuk hasil yang lebih spesifik.