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Journal Article
Role of gut microbiota in melanosis coli: from anthraquinone biotransformation to mucosal homeostasis dysbiosis
Melanosis coli (MC) is a benign and usually reversible condition characterized by brownish-black pigmentation of the colonic mucosa and is commonly associated with chronic exposure to anthraquinone laxatives (ALs). The best-established histopathological sequence involves AL-related epithelial…
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Journal Article
A mitochondrial regulatory network of ferroptosis defense in HPV-positive cervical cancer: therapeutic implications of the mitoSTAT3-DHODH axis
Human papillomavirus (HPV)-positive cervical cancer develops under persistent metabolic, replicative, and oxidative stress and frequently exhibits limited sensitivity or acquired resistance to cisplatin-based concurrent chemoradiotherapy (CCRT). In this context, ferroptosis represents a potential…
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Journal Article
Machine learning applications in predicting pharmacological treatment outcomes and responses in esophageal cancer
IntroductionThis study evaluated machine learning (ML) models predicting esophageal cancer (EC) treatment outcomes, focusing on data modalities, feature engineering, model frameworks, and validation.MethodsFollowing PRISMA guidelines (PROSPERO: CRD42024619947), six databases (2015–2024) were…
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Journal Article
Targeting FAP/CAFs to rewire immune-excluded and resistant tumor niches
Immune checkpoint blockade (ICB) has reshaped cancer therapy, yet many solid tumors remain immune-excluded, with cytotoxic T cells trapped in stromal regions and unable to access malignant nests. In these settings, cancer-associated fibroblasts (CAFs) and their extracellular matrix programs act as…
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Journal Article
Banxia xiexin decoction and its bioactive metabolites: multi-targeted mechanisms for suppressing gastric cancer progression, reversing chemoresistance, and remodeling the tumor microenvironment
Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide, primarily due to late diagnosis and limited benefit from surgery alone. Although chemotherapy, targeted agents, and immunotherapy have improved outcomes for selected patients, their clinical benefits are often…
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Journal Article
The METOD study: exploring metabolism, emotional blunting and treatment outcomes in depression – A naturalistic, two-phase observational protocol
IntroductionMajor depressive disorder (MDD) constitutes a substantial global health burden, profoundly undermining psychosocial functioning and quality of life, and the persistent limitations of treatment efficacy—despite advances in neurobiology and pharmacotherapy—underscore its considerable…
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Journal Article
Polyphenol-enriched fraction of Acacia seyal Delile (Mimosaceae) inhibits human triple-negative breast cancer cells and exhibits anticancer and immunomodulatory effects in a DMBA-induced breast cancer model
IntroductionBreast cancer killed 665,684 patients globally in 2022 despite government efforts and conventional therapies. The hydro-ethanolic extract of Acacia seyal, a sub-Saharan African ethnomedicinal plant, showed moderate cytotoxicity, significant anti-migration and in vivo preventive effects…
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Journal Article
Gut-bone axis: mechanisms and intervention effects of Chinese botanical drugs in osteoporosis management
Osteoporosis (OP) is a systemic skeletal disorder characterized by decreased bone mass, impaired bone microarchitecture, and elevated fracture risk. With global population aging, OP has become a major public health burden worldwide. The gut-bone axis, a critical regulatory network connecting gut…
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Journal Article
2-Pentadecyl-2-oxazoline alleviates anxiety-like behaviour and modulates the microbiota-gut-brain axis in obese mice
A bidirectional relationship between obesity and anxiety disorders has been increasingly associated with neuroinflammation and dysregulation of the gut–brain axis. Here, we investigated the pharmacological effects of the N-palmitoylethanolamine oxazoline derivative 2-pentadecyl-2-oxazoline (C15OXA)…
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Journal Article
Mechanism-informed neuroprotection in acute ischemic stroke treated with thrombectomy: a systematic review and meta-analysis of randomized controlled trials
BackgroundDespite the success of endovascular thrombectomy (EVT) in restoring large-vessel patency in acute ischemic stroke (AIS), a substantial proportion of patients fail to achieve functional independence, largely due to ischemia-reperfusion injury (IRI) at the tissue level. Pharmacological…
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Journal Article
Ameliorative effects of a Lactobacillus paracasei and Puerariae Radix extract complex on hydrogen peroxide-induced oxidative damage in zebrafish
ObjectiveThis study aimed to investigate the protective effects of a novel composite comprising Lactobacillus paracasei and Puerariae Radix extract (Lac_PRE) against hydrogen peroxide (H2O2)-induced multi-organ oxidative damage in a zebrafish model.MethodsAn acute toxicity test was conducted to…
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Journal Article
Fraxini cortex (Qinpi): reframing a traditional heat-clearing botanical drug as a systemic immune-metabolic regulator
Fraxini Cortex (Qinpi), a traditional Chinese medicine used for millennia for “Qingre” (heat-clearing), is now being re-evaluated in the context of modern immunology and systems pharmacology. Its traditional applications in treating inflammatory conditions hint at a broader, systemic regulatory…
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Journal Article
Proteomic profiling reveals treatment-dependent inflammatory signatures and identifies biomarkers of refractory age-related macular degeneration
BackgroundAge-related macular degeneration (AMD) is a severe eye disease that affects the macula, the central area of the retina. Current treatment consists of intravitreal injections of vascular endothelial growth factor (VEGF) inhibitors. However, some patients remain refractory to treatment even…
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Journal Article
Efficacy of erector spinae plane block with liposomal bupivacaine for postoperative analgesia in patients undergoing open spinal surgery: a randomized controlled trial
BackgroundLiposomal bupivacaine (LB) provides prolonged postoperative analgesia. This study aimed to evaluate the analgesic efficacy of erector spinae plane block (ESPB) using LB in patients undergoing spinal surgery.MethodsA total of 64 patients undergoing elective spinal surgery were randomly…
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Journal Article
The TASK-1 and TASK-3 activator JG-C3-98 attenuates cold and mechanical responses in primary somatosensory neurons
K2P channels underlie background K+ currents that act as brakes on neuronal excitability. In the somatosensory system, the K2P channels TASK-1 and TASK-3 play a relevant role in cold sensing, mechanosensitivity, and pain. Combining molecular docking and molecular dynamic simulations, patch-clamp…
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Journal Article
EZH2 blockade reverses doxorubicin resistance by inducing metabolic vulnerability and enhancing DNA damage in breast cancer
BackgroundDoxorubicin (DOX) resistance remains a major obstacle to effective chemotherapy in breast cancer. However, the pharmacologically actionable regulators sustaining this resistant phenotype and its therapeutic vulnerabilities remain incompletely defined.MethodsDOX-resistant breast cancer…
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Journal Article
Synthesis, characterization, and in silico and in vivo profiling of selective cyclo-oxygenase-2 inhibitors of indazole–indolinone derivatives with anti-inflammatory and analgesic potency
BackgroundThe intensive use of non-steroidal anti-inflammatory and analgesic drugs (NSAIDS) worldwide poses a challenge to scientists because of the adverse side effects. This article aims to synthesize a novel group of 1-aminoindazole-isatin Schiff base compounds considering their potency as…
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Journal Article
Comparative evaluation of isolation protocols for Aloe vera-derived extracellular vesicles
The primary objective of this investigation was to systematically evaluate four distinct protocols for extracting extracellular vesicles (EVs) from Aloe vera, aiming to establish a methodology that maximizes both yield and purity. Fresh Aloe vera gel served as the source material for EV isolation…
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