31,912 results
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Journal Article
Crude Astragalus polysaccharides ameliorate cognitive impairment by preserving blood-brain barrier integrity and suppressing GSDMD-mediated pyroptosis in jellyfish-envenomed mice
IntroductionJellyfish envenomation is an escalating global health threat that can induce severe neurotoxic consequences, but effective therapeutic strategies remain limited. This study investigated whether crude astragalus polysaccharides (APS) protect against jellyfish venom-induced cognitive…
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Journal Article
Psychosocial and clinical determinants of medication adherence among elderly chronic disease patients in China
BackgroundIdentifying psychosocial factors associated with medication adherence is critical to optimize chronic disease management in elderly patients. This study aimed to explore key psychosocial and clinical determinants of medication adherence and their synergistic interactions among…
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Journal Article
Curcumin protects high glucose-induced diabetic myocardial injury by regulating Nrf2 and PI3K/AKT pathways
Hyperglycemia can lead to excessive production of reactive oxygen species (ROS), contributing to diabetes and its complications, such as diabetic cardiomyopathy (DCM). This study aims to elucidate the protective mechanisms of Curcumin (CUR) against hyperglycemia-induced cardiomyocyte injury. We…
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Analysis of the interaction network relationship between drugs using a graph neural network
IntroductionThe ever-increasing complexity of biochemical systems, alongside the rapid growth of pharmaceutical and biomedical data, underscores the urgent need for intelligent, scalable, and interpretable computational models. These models must be capable of supporting next-generation…
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Journal Article
Microbiota-miR-101 interactions in obesity-associated colorectal cancer: from barrier dysfunction to precision therapeutic strategies
Colorectal cancer (CRC) remains a leading cause of cancer-related morbidity and mortality worldwide, with obesity recognized as a major modifiable risk factor. Obesity-associated CRC is characterized by systemic low-grade inflammation, altered lipid metabolism, and gut microbial dysbiosis, all of…
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Journal Article
Pharmacological safety and real-world efficacy of the potassium-competitive acid blocker fexuprazan in cardiovascular patients receiving antithrombotic therapy: a prospective cohort study (FEXGARD)
Background and AimsGastroesophageal reflux disease (GERD) is common in patients with CVD receiving long-term antithrombotic therapy, increasing gastrointestinal (GI) bleeding risk. Potassium-competitive acid blockers, such as fexuprazan, provide rapid and potent acid suppression; however, relevant…
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Journal Article
Japanese evidence on Janus kinase inhibitors for rheumatoid arthritis: a narrative review of risk-optimized use
BackgroundJanus kinase inhibitors (JAKi) have expanded treatment options for rheumatoid arthritis (RA) by providing rapid and effective oral therapy. However, their optimal use has become increasingly complex after the emergence of safety concerns involving serious infections, herpes zoster (HZ)…
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Journal Article
The relevance of phenotypic definition in treatment resistant forms of major depressive disorder: a narrative review
Treatment-resistant depression (TRD) represents a major clinical and public health challenge contributing disproportionately to disability, healthcare utilisation, and societal costs. Progress in the field may be hindered by substantial heterogeneity in TRD phenotypic definitions and…
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Journal Article
The efficacy of ultrasonic ablation combined with medication in the treatment of adenomyosis: a systematic review and network meta-analysis
BackgroundAdenomyosis occurs when tissue from the inner lining of the endometrium grows into the muscle wall of the myometrium. Previous studies have suggested that High-Intensity Focused Ultrasound (HIFU) combined with medications may improve treatment outcomes for adenomyosis; however, the…
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Journal Article
Tripterygium wilfordii Hook F accelerates CD4+ T-cell recovery in ART-treated people living with HIV with incomplete immune reconstitution: a longitudinal cohort study
BackgroundIncomplete immune reconstitution (INR) affects 9%–45% of ART-treated people living with HIV (PLWH) and is associated with increased morbidity and mortality. Chronic immune activation and inflammatory signaling, particularly via the IP-10/CXCL10 pathway, are central to its pathogenesis…
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Journal Article
Intelligent CpG nanoplatforms for targeted cancer immunotherapy and immune remodeling
CpG oligonucleotides are potent immunoadjuvants that hold great promise for cancer immunotherapy, but their clinical use is limited by in vivo instability, off-target toxicity, and poor tumor targeting. Intelligent nanoplatforms offer effective solutions to these challenges by protecting CpG…
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Journal Article
Metal-based nanomaterials for cancer phototherapy: current advancements and translational challenges
Cancer remains a leading global health challenge, with limitations in chemotherapy, radiotherapy, and immunotherapy driving interest in alternative modalities. Phototherapy, comprising photodynamic therapy and photothermal therapy, has shown promising antitumor efficacy, yet conventional…
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Journal Article
Efficacy and safety of combining commercial Chinese polyherbal preparation with conventional medicine in the treatment of coronary microvascular disease: a systematic review and network meta-analysis
ObjectiveTo systematically assess and compare the efficacy and safety of 19 commercial Chinese polyherbal preparation for coronary microvascular disease (CMVD) through a frequentist network meta-analysis (NMA) of randomized controlled trials.MethodsA comprehensive search was performed across…
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Journal Article
Post-marketing safety evaluation of mirogabalin using the JADER database
BackgroundMirogabalin, a novel third-generation α2-δ calcium channel ligand, is approved for diabetic peripheral neuropathic pain (DPNP). However, its post-marketing safety profile remains insufficiently characterized, particularly regarding novel signals and comparative safety profiles with…
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Journal Article
The impact of China’s drug regulatory reform on access to orphan drugs: a cross-sectional study of diseases listed in the rare disease catalog
ObjectiveChina released two batches of the Rare Disease Catalog in 2018 and 2023, respectively, listing a total of 207 diseases. This study aims to analyze the accessibility of medications for diseases included in the catalog and assess the impact of drug regulatory reforms on the supply of…
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Journal Article
Polygonatum sibiricum combined with Poria cocos prevents spleen deficiency constipation via the gut microbiota–mediated brain–gut axis
IntroductionThe study evaluates the preventive effects of Polygonatum sibiricum and Poria cocos (3:1) on spleen deficiency constipation in mice, focusing on the brain-gut axis, gut microbiota, and oxidative stress. The findings aim to inform the prevention and treatment of this…
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Journal Article
Research progress of artificial intelligence in high-throughput drug screening
High-throughput screening (HTS) is widely used in modern drug discovery. It enables batch activity testing of compounds and provides important support for the identification of active compounds. However, its screening efficiency and accuracy need to be improved. To address this issue, artificial…
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Journal Article
Integrating CRISPR functional genomics with admixture-aware psychotropic pharmacogenetics in Brazil
Variability in the clinical response to psychotropic drugs remains a major barrier to effective psychiatric care. Pharmacogenetics offers a powerful framework for individualizing antidepressant and antipsychotic therapy, yet its implementation is complicated in genetically diverse populations. In…
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Journal Article
Targeting STAT3 in systemic lupus erythematosus and lupus nephritis: mechanisms, therapeutic advances, and structure-informed perspectives
This review summarizes the mechanistic and therapeutic relevance of Signal Transducer and Activator of Transcription 3 (STAT3) in systemic lupus erythematosus (SLE) and lupus nephritis (LN), with an emphasis on how structural information can inform drug development. STAT3 integrates cytokine- and…
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Journal Article
Targeting the JAK/STAT pathway with isoliquiritigenin in ovarian cancer: molecular mechanisms and therapeutic implications
Ovarian cancer, one of the most common gynecological malignancies, ranks as the fifth leading cause of cancer death in women. To investigate the mechanism by which isoliquiritigenin (ISL) regulates the JAK/STAT signaling pathway in ovarian cancer intervention, this review integrates cellular…
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