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Artikel Jurnal
Formononetin: a promising therapeutic agent targeting the gut-lung axis in acute lung injury
BackgroundAcute lung injury (ALI) is a common acute inflammatory lung disease in critical clinical conditions, with a complex pathogenesis and limited available treatment options. Although the gut-lung axis has been identified as an emerging field of host-related microbiota in various chronic lung…
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Artikel Jurnal
A comprehensive review of ischemic heart disease: pathophysiology, current treatments, natural products-based therapies, and nanotherapeutics
Ischemic heart disease (IHD) is one of the major cardiovascular disorders leading to global morbidity and mortality and represents a huge burden on individuals and the healthcare system worldwide. Classically, it is attributed to obstructive atherosclerotic plaques in the epicardial coronary…
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Artikel Jurnal
Sigma-1 and Sigma-2 receptors exhibit divergent genome-wide Co-expression architectures in human brain despite shared subcellular localization
The sigma-1 receptor (SIGMAR1) and sigma-2 receptor (TMEM97) are both enriched at the mitochondria-associated membrane (MAM) and have been pharmacologically co-classified for decades, yet their functional relationship at the transcriptomic level remains uncharacterized. We performed genome-wide…
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Artikel Jurnal
Human leukocyte antigen pharmacogenetics in infectious diseases: anti-infective drug toxicity and host immune response
Human leukocyte antigen (HLA) polymorphisms are central to anti-infective pharmacogenetics and to inter-individual variability in infection outcomes and vaccine responses, but clinical relevance depends on whether an association changes treatment or prevention decisions. This narrative review is…
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Artikel Jurnal
Mechanistic elucidation of Wuling Powder targeting macrophage polarization to ameliorate renal ischemia-reperfusion injury via multidimensional computational systems pharmacology coupled with experimental validation
IntroductionThe blurry mechanism of Wuling Powder (WLP) in treating renal ischemia-reperfusion injury (R–IRI) has greatly hindered its clinical promotion and application as well as the development of modern preparations. This study applied computational systems pharmacology combined with…
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Artikel Jurnal
Integrated transcriptomics identifies ER stress–associated apoptosis in post-resuscitation AKI and supports early Dl-3-n-butylphthalide–associated renoprotection in a porcine TCA model
BackgroundDl-3-n-butylphthalide (NBP) is a small-molecule compound derived from celery seeds with anti-inflammatory, antioxidant, and anti-apoptotic properties. Although NBP has shown protective effects in various kidney diseases, its role in traumatic cardiac arrest (TCA)-induced acute kidney…
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Artikel Jurnal
Effect of combined aspirin and statin therapy on mortality reduction in sepsis-induced myocardial injury
IntroductionSepsis-induced myocardial injury (SIMI) is a severe complication with high mortality and limited effective treatments. Although combined aspirin and statin therapy is cardioprotective in coronary artery disease, its impact on SIMI outcomes remains unclear.MethodsUsing the MIMIC-IV…
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Artikel Jurnal
Drying methods for Rheum tanguticum: a comprehensive study of quality traits and metabolite dynamics
Rheum tanguticum (R. tanguticum) originates from high-altitude regions such as Qinghai and Gansu in China. It serves as both a precious traditional medicinal botanical drug and a potential functional food, and its extensive pharmacological activities have stimulated global demand. However, existing…
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Artikel Jurnal
Computational pharmacovigilance of tranexamic acid: implications for intracerebral hemorrhage based on FAERS database and network toxicology
BackgroundTranexamic acid (TXA) is a widely used antifibrinolytic agent for the management of hemorrhagic disorders and has increasingly been investigated for the treatment of intracerebral hemorrhage (ICH). However, TXA-associated adverse drug events (ADEs), particularly neurological…
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Artikel Jurnal
The tumor microenvironment: a dynamic ecosystem and therapeutic nexus in modern oncology
The tumor microenvironment (TME) has emerged as a central orchestrator of carcinogenesis, therapeutic resistance, and immune evasion, fundamentally reshaping the understanding of cancer as an ecosystem disease rather than a cell-autonomous genetic disorder. This review synthesizes contemporary…
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Artikel Jurnal
GABAA receptor dysfunction in autism spectrum disorder: molecular mechanisms and therapeutic opportunities
Autism spectrum disorder (ASD) comprises diverse neurodevelopmental trajectories in which altered circuit dynamics converge on a disturbance of excitation–inhibition balance. Genetic, postmortem, neuroimaging, and model-system evidence implicates γ-aminobutyric acid type A (GABAA) receptors as a…
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Artikel Jurnal
Effects of inclisiran therapy on metabolomic and lipoproteomic profiles in dyslipidemic patients
BackgroundInclisiran is a subcutaneously administered synthetic small interfering RNA directed against proprotein convertase subtilisin–kexin type 9, leading to sustained low-density lipoprotein cholesterol (LDL-C) reduction with a twice-yearly dosing regimen. While its lipid-lowering efficacy is…
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Artikel Jurnal
Neuroinflammation and treatment resistance in major depressive disorder
Major depressive disorder (MDD) is increasingly recognized as a multi-system disease that extends beyond neurotransmitter dysregulation. Treatment-resistant depression (TRD), which affects approximately one-third of patients who do not achieve remission with monoaminergic antidepressants, poses a…
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Artikel Jurnal
Exploring the molecular link between arecoline exposure and prostate cancer-related alterations: integrative evidence from network toxicology, single-cell transcriptomics, molecular simulation, and experimental validation
Arecoline, the major alkaloid of areca nut, is a common exposure in chewing products, but its relationship with prostate cancer (PCa) is unclear. We integrated network toxicology, bulk RNA machine learning, single-cell transcriptomics, molecular simulation, and in vitro validation to prioritize…
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Artikel Jurnal
Establishing a direct interaction between the 19,20-EDP analog SA-22 and SIRT3: impact on cardiac mitochondrial homeostasis
BackgroundDespite extensive study, the structural, metabolic, and mechanistic heterogeneity amongst polyunsaturated fatty acids (PUFA) have confounded identification of their molecular targets and roles in cardiovascular diseases. Previously our group demonstrated that the cardioprotective…
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Artikel Jurnal
Clinical characteristics and risk factors of severe myelosuppression in rheumatoid arthritis patients with csDMARD non-adherence: a case series
This study investigated the clinical characteristics and risk factors of bone marrow suppression in rheumatoid arthritis (RA) patients treated with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) to provide evidence for improving medication safety. We retrospectively…
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Artikel Jurnal
Larvicidal, oviposition inhibition, electrophysiological, histological, and docking activity of Eugenia uniflora L. oil against Aedes aegypti
IntroductionArboviruses represent a serious problem affecting half of the world’s population, according to the World Health Organization. Natural products are an option for combating this vector.MethodThe essential oil (EO) of E. uniflora was extracted by hydrodistillation, while the isolation of…
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Artikel Jurnal
Decoding neuroimmune ferroptotic vulnerability in isoflurane-induced neonatal neurotoxicity via the SLC7A11/GPX4 axis
IntroductionEarly-life exposure to general anesthetics has been associated with increased neurodevelopmental vulnerability, but the cell type-resolved mechanisms remain incompletely understood. Here, we investigated whether isoflurane-induced neonatal neurotoxicity is associated with a glia-linked…
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