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Artikel Jurnal
Neuroprotective effects of telmisartan in a harmaline-induced model of essential tremor: modulation of the renin-angiotensin system and inflammatory pathways
BackgroundEssential tremor (ET) is a widespread neurological disorder with mild cerebellar degeneration that affects motor coordination, causing involuntary, rhythmic tremors during action. Excessive brain renin-angiotensin system activation favors pro-inflammatory milieu that is associated with…
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Artikel Jurnal
Betahistine for residual dizziness after canalith repositioning in benign paroxysmal positional vertigo: a systematic review of randomized controlled trials
BackgroundBenign paroxysmal positional vertigo (BPPV) is the most common peripheral vestibular disorder. Although canalith repositioning maneuvers (CRMs) are highly effective, a substantial proportion of patients experience residual dizziness (RD) after successful repositioning. Betahistine has…
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Artikel Jurnal
Vitamin D and Kawasaki disease
BackgroundVitamin D deficiency has been widely reported worldwide. Vitamin D is essential for mineral homeostasis and skeletal health, and is also associated with numerous extra-skeletal diseases, including cancer, autoimmune diseases, psychosis, allergies and cardiovascular disease. Recent…
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Artikel Jurnal
Modulation of monoaminergic neurotransmission in substance use disorders: a neuropharmacological perspective focusing on plant-derived metabolites
Substance use disorders (SUDs) pose a major global health burden, often worsened by comorbid depression and anxiety. Dysregulation of monoaminergic neurotransmission, especially dopamine, serotonin, and norepinephrine transporters, underlies the reinforcing and harmful effects of addictive drugs…
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Artikel Jurnal
Research progress on potential high-risk drugs for Stevens-Johnson syndrome and toxic epidermal necrolysis with insights from adverse drug reaction database mining
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare yet life-threatening severe cutaneous adverse drug reactions (SCARs), characterized by high mortality and substantial morbidity risks. Identifying potential high-risk drugs associated with SJS/TEN is crucial for guiding…
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Artikel Jurnal
Machine learning combined with population pharmacokinetics: a hybrid model for predicting the plasma concentration of linezolid in critically ill pediatric patients
ObjectiveLinezolid is a crucial agent for treating drug-resistant Gram-positive bacterial infections in critically ill pediatric patients. However, its pharmacokinetics exhibit high inter-individual variability, making standard dosing regimens susceptible to underexposure or overexposure. This…
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Artikel Jurnal
Matrix type influences embedded patient-derived osteosarcoma organoid invasion and response to treatment
Osteosarcoma remains a lethal paediatric malignancy when it metastasises to lung, yet therapeutic progress has stalled for decades, in part because preclinical models poorly capture patient specific tumor microenvironments. Here, patient- derived osteosarcoma (PDOS) cells are assembled into…
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Artikel Jurnal
Ocular disorders during treatment with GLP-1 receptor agonists: a systematic review and meta-analysis of observational studies
IntroductionDifferent observational studies have analyzed the effects of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) on the risk of ocular adverse events (AEs). The present meta-analysis aimed to assess the effects of GLP-1 RAs on the risk of ocular AEs, including retinopathy, glaucoma…
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Artikel Jurnal
Early biomarkers associated with prenatal alcohol exposure and neurodevelopmental outcomes
Prenatal alcohol exposure (PAE) is a major early-life stressor associated with long-lasting neurodevelopmental and neurocognitive alterations. Increasing evidence from human studies indicates that PAE leaves persistent molecular signatures that can be detected in the placenta and in clinically…
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Artikel Jurnal
Exploring the association between pharmacy curricular tracks and students’ attitudes toward generic medicines: insights from a comparative study in Egypt
BackgroundUse of generic medicines enhances drug affordability and accessibility. The aim if this study was to assess the association between pharmacy educational programs and final-year pharmacy students’ perceptions and confidence in generic medicines.MethodologyA cross-sectional survey was…
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Artikel Jurnal
Qitu qushi formula ameliorates diabetic kidney disease potentially through gut microbiota-derived indole-3-propionic Acid–Mediated regulation of the Sirt1/FoxO1 pathway
BackgroundDiabetic kidney disease (DKD) is a leading cause of end-stage renal disease, and current pharmacotherapies provide limited renal protection. Qitu Qushi Formula (QTQSF), a traditional Chinese medicine prescription, has shown therapeutic potential in DKD, but its underlying mechanisms…
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Artikel Jurnal
Identification and functional characterization of plasma exosomal miR-618 as a novel biomarker in recurrent depressive disorder
BackgroundGiven the substantial clinical and financial burden of Recurrent Depressive Disorder (RDD) and the critical lack of reliable biomarkers, this study investigated plasma exosomal microRNA (miRNA) as candidate biomarkers and therapeutic targets to overcome reliance on subjective diagnosis…
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Artikel Jurnal
Plants used in medicines and foods in osteoporosis: mechanistic insights into bone-remodeling homeostasis and clinical evidence
Osteoporosis (OP) arises from the progressive uncoupling of bone remodeling, in which osteoclastic resorption exceeds osteoblastic formation under the combined influence of estrogen deficiency, nutrient insufficiency, oxidative stress, chronic inflammation, and age-related stem-cell decline…
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Artikel Jurnal
African traditional medicine: historical legacy, colonial disruption, and pathways for integration into modern healthcare
African Traditional Medicine (ATM) remains an important component of healthcare across Africa and continues to play a significant role within pluralistic healthcare systems where traditional and biomedical practices coexist. This narrative review critically examines the historical development…
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Artikel Jurnal
Integrated multi-omics analysis suggests the involvement of PI3K-Akt/p21 signaling in the anti-colorectal cancer effects of Diaphragma Juglandis Fructus extract
BackgroundColorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, underscoring the need for more effective and well-tolerated therapeutic strategies. Diaphragma Juglandis Fructus (DJF), a by-product of walnut processing used in traditional medicine, is rich in…
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Artikel Jurnal
Early life social isolation stress and pain vulnerability: unraveling neuroimmune mechanisms and central sensitization
Chronic pain is increasingly recognized as a multidimensional condition in which neuroimmune interactions shape disease vulnerability and persistence. Among the emerging pain phenotypes, nociplastic pain (defined as an alteration of nociceptive processing in the absence of clear tissue damage or…
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Artikel Jurnal
Phosphatase PTP-4 downregulates ATLN-1-mediated host defense against Pseudomonas aeruginosa infection in Caenorhabditis elegans
AimThe p38 MAPK pathway governs the core innate immune response in Caenorhabditis elegans (C. elegans), yet the negative regulatory networks preventing immune overactivation—and their potential as therapeutic targets—remain elusive. We aimed to identify novel phosphatase checkpoints in host…
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Artikel Jurnal
Repurposing ivacaftor to attenuate LPS-induced acute lung injury: evidence from a non-cystic fibrosis model
In this study, we explicitly evaluate the anti-inflammatory effects of ivacaftor as a route-of-delivery comparison (intraperitoneal vs. intratracheal) in a reproducible LPS-induced lung inflammation model. We evaluated the effects of ivacaftor [40 mg/kg, administered either intraperitoneally (IP)…
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Artikel Jurnal
Efficacy and safety of yaobitong capsules for lumbar disc herniation: a systematic review and meta-analysis
BackgroundLumbar disc herniation (LDH) is a major contributor to the global burden of low back pain. Yaobitong (YBT) capsules are a commercial Chinese polyherbal preparation that has been widely used to treat LDH. However, its efficacy and safety require comprehensive evaluation.MethodsA…
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Artikel Jurnal
Niraparib promotes ferroptosis by inhibiting TM4SF1 expression through ALKBH1-mediated 6mA modification in BRCA wild-type ovarian cancer
ObjectiveNiraparib significantly improves the prognosis of patients with BRCA wild-type ovarian cancer (BRCAwt OC). However, the underlying mechanisms remain elusive. N6-methyladenine DNA (6mA) modification has emerged as a critical epigenetic regulator in cancer progression. We investigated…
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