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Artikel Jurnal
Bruceine D attenuates prostate cancer growth and motility by suppressing PI3K/AKT signaling and downregulating CXCL16: implications for skeletal metastasis in orthopedic oncology
IntroductionProstate cancer often reaches bone, which poses a challenge in orthopedic oncology since few therapies directly suppress tumor growth in bone. Bruceine D (BD) is a quassinoid from Brucea javanica. It is known anticancer activity but its effects on prostate cancer have not been…
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Artikel Jurnal
Human placental extract, melsmon, suppresses stress-induced neuroinflammation and peripheral inflammation in a mouse model of depression
Neuroinflammation and hyperactivation of the hypothalamic–pituitary–adrenal (HPA) axis triggered by stress have been implicated in the pathophysiology of depression, highlighting the need for novel therapeutic approaches targeting these mechanisms. Placental extracts have been reported in clinical…
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Artikel Jurnal
Pharmacokinetics, safety, and population pharmacokinetic profiles of Ritanine® in Chinese subjects with impaired or normal liver function: a Phase I trial
ObjectivesRitanine (HR20013) is a fixed-dose combination of fosrolapitant (218 mg, a rolapitant prodrug) and palonosetron (0.25 mg), designed to enhance rolapitant’s solubility and reduce allergic reactions associated with intravenous administration. Metabolized primarily by the liver, hepatic…
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Artikel Jurnal
Antioxidant, anti-inflammatory, and phytochemical properties of Juniperus osteosperma (Torr.) little hydrosol: an in vitro evaluation
The hydrosol of Juniperus osteosperma (Torr.) Little has scarcely been characterized from a chemical and biological perspective. In this study, the phytochemical profile and in vitro antioxidant, anti-inflammatory, and antibacterial activities of the plant were evaluated. Antioxidant activity was…
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Artikel Jurnal
Efficacy and safety of small interfering RNA (siRNA) therapies for hypertriglyceridemia and mixed dyslipidemia: an updated systematic review and meta-analysis
BackgroundHypertriglyceridemia (HTG) and mixed dyslipidemia are significant risk factors for cardiovascular diseases. Despite the widespread use of traditional therapies, many patients continue to experience elevated triglycerides and residual cardiovascular risk. Small interfering RNA (siRNA)…
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Artikel Jurnal
Which commercial Chinese polyherbal preparations combined with ACEI/ARB is effective and safe for IgA nephropathy? A systematic review and network meta-analysis
BackgroundThis systematic review and network meta-analysis (NMA) evaluates and compares the efficacy and safety of six commercial Chinese polyherbal preparations (Bailing Capsule (BL), Huangkui Capsule (HK), Tripterygium Glycosides (TG), Jinshuibao Capsule (JSB), Huobahuagen Tablet (HBHG), and…
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Artikel Jurnal
Lorazepam during breastfeeding: a pharmacokinetic case report and exploratory pharmacovigilance assessment – a contribution from the ConcePTION project
IntroductionKnowledge regarding lorazepam use during breastfeeding is limited and so are quantitative data on lorazepam transfer into human milk. Lorazepam transfer to human milk was characterized in a single case and pharmacovigilance databases were explored.MethodsA clinical lactation study was…
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Artikel Jurnal
Update in treatment options for congenital and immune thrombotic thrombocytopenic purpura
Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy resulting either from congenital deficiency (cTTP) or acquired (immune) deficiency (iTTP) of A Disintegrin and Metalloprotease with ThromboSpondin-type 1 motif, member 13 (ADAMTS13). Deficiency of ADAMTS13 leads to…
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Artikel Jurnal
Exposure-response relationship of sertraline in pediatric patients with anxiety disorders: a population pharmacokinetic analysis
BackgroundSertraline is widely used for the treatment of anxiety disorders in pediatric populations; however, substantial interindividual pharmacokinetic (PK) variability may significantly influence therapeutic efficacy and the occurrence of adverse events (AEs).ObjectiveTo characterize the…
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Artikel Jurnal
Alternol inhibits GAPDH activity and disrupts glycolytic flux preferentially in cancer cells
IntroductionWe and others demonstrated that the natural compound Alternol induces apoptosis preferentially in human cancer cells. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) participates in cellular glycolysis, important for energy homeostasis, especially in cancer cells. We recently…
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Artikel Jurnal
Isolation, structural elucidation, and antioxidant potential of phytomelatonin from tomato (Solanum lycopersicum L.) leaves
Melatonin (N-acetyl-5-methoxytryptamine) is an indoleamine compound present in both animal and plant kingdoms. Melatonin, a potent antioxidant, is currently produced synthetically, which is often associated with the presence of toxic by-products. This study presents a high-yield alternative by…
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Artikel Jurnal
The potential value of curcumin in breast cancer: a systematic review and meta-analysis of preclinical studies
ObjectivesCurcumin has attracted considerable attention due to its multi-target anti-tumor properties and favorable safety profile. However, preclinical studies in breast cancer are challenged by considerable model heterogeneity and inconsistent findings. The objective of this study is to…
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Artikel Jurnal
Machine learning–driven discovery of antimicrobial peptides against Pseudomonas aeruginosa
IntroductionAntibiotic resistance has become a global health crisis, driving the urgent need for novel antibacterial strategies. Antimicrobial peptides (AMPs) have emerged as promising therapeutic candidates due to their broad-spectrum activity and low propensity for resistance development…
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Artikel Jurnal
Compound 4′-O-methylbroussochalcone B attenuates LPS/ATP-induced macrophage pyroptosis in vitro through modulation of the NLRP3 inflammasome and MAPK/NF-κB pathways
BackgroundThe compound 4′-O-methylbroussochalcone B (4′-O-M) is a chalcone-type flavonoid isolated from Psoralea corylifolia, a traditional Asian medicinal herb. While studies have reported its antioxidant and anti-inflammatory activities, its effects on macrophage inflammatory signaling and NLRP3…
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Artikel Jurnal
Antidepressant effects and therapeutic potential of naringenin: a systematic review and meta-analysis of preclinical studies
BackgroundThe prevalence of depression has increased steadily over recent decades, making it a major global public health concern. Although currently available pharmacotherapies demonstrate therapeutic efficacy, their clinical utility is often limited by adverse effects. Naringenin, a naturally…
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Artikel Jurnal
The dysregulated unfolded protein response in diabetic kidney disease: mechanisms and crosstalk with cell death pathways
Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage kidney failure worldwide, yet the molecular mechanisms driving progressive renal injury remain incompletely understood. Chronic metabolic stress in diabetes disrupts endoplasmic reticulum (ER) homeostasis…
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Artikel Jurnal
Challenges and pathways to herbal ethical approval: an institutional case study of a randomized controlled trial on Moringa oleifera Lam.
Clinical trials are essential for validating the safety and efficacy of traditional medicines; however, their conduct in Africa is significantly hindered by resource constraints, a lack of standardized regulatory frameworks, and insufficient guidance for navigating complex ethical review processes…
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Artikel Jurnal
Quercetin in bone regeneration: optimization of drug delivery system and study of its synergistic mechanism with bone tissue engineering
Skeletal diseases impose a heavy global burden, creating an urgent demand for safe and effective therapeutic strategies for bone regeneration. Quercetin, a natural flavonoid compound, has attracted considerable attention owing to its potential to promote bone formation and inhibit bone resorption…
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Artikel Jurnal
Can the two-point method based on peak and trough concentrations accurately estimate the area under the curve of polymyxin B? A Monte Carlo simulation study
BackgroundThe area under the concentration‒time curve (AUC) is recognized as the therapeutic drug monitoring index of polymyxin B. The two-point method, which is based on peak and trough concentrations, is recommended for AUC estimation. However, its accuracy needs to be fully elucidated.MethodsA…
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