31.912 hasil
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Artikel Jurnal
Drug repurposing of sophoridine for sepsis-induced organ injury: from in-depth analysis of a single agent to a multi-target therapeutic paradigm
Sepsis-induced immune dysregulation and multiple organ dysfunction present formidable clinical challenges that conventional single-target therapies fail to address. This review evaluates the potential of the natural quinolizidine alkaloid sophoridine for drug repurposing in sepsis. Pharmacological…
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Artikel Jurnal
Adolescent stress and alcohol are associated with CX3CR1-linked endocrine–cardiac signatures and anxiety-like behavior in mice
BackgroundAdolescence is a vulnerable window in which stress and alcohol exposure can induce long-lasting neuroimmune, endocrine, and cardiac molecular alterations. The fractalkine axis (CX3CL1/CX3CR1) regulates neuron–microglia signaling and inflammatory responses, but its role in linking…
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Artikel Jurnal
Direct NLRP3 inflammasome inhibitors for cardiovascular therapeutics: a comparative review of synthetic and natural candidates
The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome has emerged as a critical mediator in cardiovascular diseases, connecting cholesterol crystals and metabolic danger signals to atherogenic inflammation, myocardial injury, and adverse remodeling. Using direct inhibitors…
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Artikel Jurnal
Arctigenin as a promising anticancer agent: a comprehensive review of molecular mechanisms across major carcinomas
Despite the presence of numerous efficacious bioactive compounds, the development of effective cancer therapies remains necessary. Thus, the exploitation of the medicinal potential of bioactive compounds in cancer management has become an urgent demand. Arctigenin (AG), a natural lignin derived…
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Artikel Jurnal
Holarrhena pubescens (Kutaj) bark extract mitigates SDS-induced IBD-like pathologies in Drosophila melanogaster by preserving barrier integrity and antioxidant defense
Inflammatory bowel disease (IBD) is a group of chronic conditions characterized by relapsing inflammation of gastrointestinal tract. Conventional treatments for IBD are confronted with various challenges including treatment failure, a therapeutic ceiling that restricts effectiveness and associated…
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Artikel Jurnal
Targeting BRD4 in gastric cancer: promoting apoptosis and suppressing tumor progression
BackgroundThe MYC pathway is highly activated in gastric cancer (GC), but the MYC oncogene’s structural biology makes direct pharmacological inhibition very difficult. We hypothesized that BRD4, as a major co-activator of MYC, maintains MYC-dependent survival circuits, thus making BRD4 a key…
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Artikel Jurnal
Computer-aided drug discovery: historical foundations, practical AI tools, and emerging ethical considerations
Computer-aided drug discovery (CADD) has become an integral component of modern drug development, supporting hit identification, lead optimisation, and candidate refinement across both academia and industry. Over 4 decades of methodological progress have contributed to the discovery or optimisation…
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Artikel Jurnal
The CHRNA5 rs16969968 variant is associated with MMP-9 expression and inflammatory signaling in COPD in a West Bengal population, India
BackgroundHost genetic variation plays a critical role in shaping inflammatory responses to chronic environmental exposure in Chronic Obstructive Pulmonary Disease (COPD). The non-synonymous CHRNA5 polymorphism rs16969968 (G>A; D398N) has been associated with nicotine dependence; however, its…
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Artikel Jurnal
Chemical and enantioselective GC–MS characterization of Minthostachys mollis (Benth.) Griseb. Essential oil from Peru and its acetylcholinesterase inhibitory activity
BackgroundMinthostachys mollis (Benth.) Griseb., an aromatic medicinal plant widely used in traditional medicine in Peru, was investigated using an integrated chemical, enantioselective, and acetylcholinesterase (AChE) inhibitory approach.AimTo characterize the chemical and enantiomeric composition…
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Artikel Jurnal
Comparison of conbercept and ranibizumab for the treatment of idiopathic choroidal neovascularization using optical coherence tomography angiography and multifocal electroretinography
ObjectiveThis study aimed to compare the efficacies of conbercept and ranibizumab for the treatment of idiopathic choroidal neovascularization (ICNV) using optical coherence tomography angiography (OCTA) and multifocal electroretinography (mfERG).MethodsSixty patients with ICNV were retrospectively…
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Artikel Jurnal
Qingre–Huatan–Liqi formula attenuates FPM-induced lung injury via modulation of MAPK signaling and NETs formation
BackgroundFine particulate matter (PM2.5, FPM) can induce and exacerbate chronic obstructive pulmonary disease (COPD) by triggering oxidative stress and multiple other pathogenic pathways. Our previous studies have demonstrated that Qingre–Huatan–Liqi formula (QRHTLQ) can improve the symptoms of…
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Artikel Jurnal
Targeting NAT10 with Remodelin in cancer drug resistance: mechanisms, preclinical evidence, and combination strategies
Drug resistance remains a major challenge in cancer therapy and limits the efficacy of chemotherapy, targeted therapy, and immunotherapy. Recent studies highlight RNA epitranscriptomic regulation, especially N4-acetylcytidine (ac4C), as an important mechanism in tumor adaptation. NAT10, the main…
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Artikel Jurnal
Clinical utility of therapeutic drug monitoring of sertraline: a transdiagnostic systematic scoping review
IntroductionTherapeutic drug monitoring (TDM) is the quantification and interpretation of drug concentrations in blood to personalize pharmacotherapy. Dose adjustment of sertraline is currently based on clinical judgment. Preliminary evidence shows relationships between sertraline blood…
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Artikel Jurnal
Integrative genomic and functional analysis of RAB3B in lung adenocarcinoma: associations with m6A modification and ceRNA networks
BackgroundLung adenocarcinoma (LUAD) is characterized by high mortality and recurrence. This study investigated the clinical significance and biological role of RAB3B as a potential biomarker in LUAD.MethodsWe analyzed The Cancer Genome Atlas and Gene Expression Omnibus datasets for RAB3B…
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Artikel Jurnal
Serum potassium and high-altitude coronary microvascular disease: a propensity score matched analysis revealing a linear dose-response relationship
BackgroundHigh-altitude exposure precipitates coronary microvascular disease (CMVD), a pathology linked to hypoxia-induced ion channel dysfunction. However, prior observational evidence connecting serum potassium to CMVD resilience is limited by residual confounding, and the precise dose-response…
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Artikel Jurnal
Antidepressant-like effects of cannabidiol when combined with temozolomide in adult rats
There is a need for characterizing more efficacious therapeutic strategies for glioblastoma multiforme to overcome treatment resistance to the standardized use of temozolomide as well as to better treat its debilitating comorbidities like depression. In this context, combination therapies…
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Artikel Jurnal
Safety profile of azvudine in COVID-19 patients with renal impairment: a retrospective analysis
ObjectiveAzvudine (FNC), an antiviral drug approved in China for the treatment of Coronavirus disease 2019 (COVID-19) infection, has not yet established a well-defined safety profile in patients with renal impairment. This study aimed to evaluate the safety of using FNC in patients with renal…
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Artikel Jurnal
Combined treatment with Acorus tatarinowii Schott and Panax notoginseng saponins ameliorates brain–gut axis dysfunction in MCAO/R rats with suppression of TLR4/MyD88/NF-κB signaling and associated gut microbiota changes
Background and purposeCerebral ischemia-reperfusion injury disrupts the brain-gut axis, which involves the activation of the toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)/nuclear factor-kappa B (NF-κB) pathway and gut microbiota dysregulation. Acorus tatarinowii Schott (AT)…
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Artikel Jurnal
Desflurane post-conditioning inhibits HMGB1 nucleocytoplasmic translocation via the SIRT1/HMGB1 axis to attenuate hepatic ischemia-reperfusion-induced acute lung injury in young rats
Acute lung injury (ALI) is a common clinical complication in pediatric patients undergoing perioperative liver transplantation, and therapeutic approaches are limited. While desflurane exhibits organ-protective potential, its specific efficacy against hepatic ischemia-reperfusion (HIR)-induced ALI…
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Artikel Jurnal
An integrated network toxicology and multi-omics study identifies ENO1 as a candidate mediator in benzo[a]pyrene-related gastric cancer progression
This study employed an integrative toxicogenomic and multi-omics prioritization approach, combined with preliminary in vitro validation, to identify candidate mediators of benzo [a]pyrene (BaP)-associated gastric cancer progression. A BaP-target-gastric cancer interaction network was constructed by…
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