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Artikel Jurnal
Recurrent hyperammonemic encephalopathy in a breast cancer patient receiving capecitabine therapy: a case report and literature review
Capecitabine-induced hyperammonemic encephalopathy represents a rare adverse event that can complicate clinical diagnosis. To accurately diagnose this condition, clinicians should consider a combination of factors, including the patient’s history of capecitabine use, clinical manifestations of…
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Artikel Jurnal
The benefits of influenza vaccination in patients with cardiovascular disease: a systematic review and meta-analysis
BackgroundThe clinical impact of high-dose influenza vaccination on cardiovascular outcomes in patients with established cardiovascular disease (CVD) remains controversial. To this end, our study aimed to assess the impact of influenza and high-dose influenza vaccine on cardiovascular outcomes in…
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Artikel Jurnal
Prediction of infliximab and anti-drug antibody concentrations in patients with inflammatory bowel disease using machine learning models with real-world data from a prospective cohort study
BackgroundAlthough population pharmacokinetic models are the standard approach for identifying inter-individual variability and optimizing infliximab concentration, their development and validation are complex and time-consuming. Therefore, this study aimed to develop and evaluate machine learning…
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Artikel Jurnal
Wedelolactone, a natural coumestan with multiple pharmacological effects
Natural products, especially those from medicinal plants, have been increasingly attractive to researchers. Wedelolactone (WL) is a natural coumestan that was first isolated from Wedelia Chinensis. The past decades have seen an increase in the pharmacological reports on this compound, which show…
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Artikel Jurnal
Antitumor effects of LPM5140276 and its potential combination with SHP2 inhibition in KRASG12D-mutant cancer
KRASG12D is a predominant mutation in pancreatic and colorectal cancers whose targeting has remained a therapeutic challenge. In this study, we introduced LPM5140276 as a potent KRASG12D inhibitor that forms a salt bridge with the Asp12 residue; furthermore, we evaluated its antitumor efficacy…
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Artikel Jurnal
Efficacy and safety of midazolam versus dexmedetomidine in mechanically ventilated intensive care unit patients: a systematic review and meta-analysis
BackgroundMidazolam and dexmedetomidine are widely used sedatives for mechanically ventilated patients in the intensive care unit (ICU). However, their comparative effectiveness and safety remain debated. This systematic review and meta-analysis aimed to evaluate randomized controlled trials (RCTs)…
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Artikel Jurnal
Innovative dual-functional hybrid cationic PEGylated proniosomes as a smart nano-platform for Boosted vaginal delivery: multi-level in-vitro, ex-vivo, microbiological, and in-vivo studies
Introduction: Vaginal candidiasis remains a recurrent fungal infection affecting millions of women worldwide, necessitating innovative local delivery systems to overcome poor drug solubility and mucosal barriers. This study introduces Dual-Functional Hybrid Cationic PEGylated Proniosomes (DHCPP) as…
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Artikel Jurnal
Boehmeria nivea (L.) Gaud. ameliorate oxidative stress-mediated inflammatory Responses and apoptosis in LPS/CSC-induced chronic obstructive pulmonary disease mouse model
IntroductionBoehmeria nivea (L.) Gaud. has traditionally been regarded as a medicinal food with applications in various inflammatory disorders. However, its role in chronic obstructive pulmonary disease (COPD) has not yet been clarified.MethodsIn this study, the preventive efficacy of the ethyl…
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Artikel Jurnal
Troxerutin, a herbal metabolite with antidiabetic and antihypercholesterolemic potential, regulates metabolic gene activity in male diabetic rats
Background/ObjectiveThis study evaluated the antidiabetic and antihypercholesterolemic potential of the botanical metabolite troxerutin (TRX) and compared it with that of metformin in high-fat diet-fed streptozotocin-induced diabetic male Wistar rats.MethodsThe rats (n = 48) were divided into six…
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Artikel Jurnal
Therapeutic effects of Lactobacillus rhamnosus, thymol and their combination against neurotoxicity in propionic acid (PA)-induced autistic rats: insights into the role of the Nrf2/HO-1, Wnt3/β-catenin/GSK3β BDNF/p-TrkB/CREB, pI3K/Akt/mTOR, AMPK/SIRT-1, and PERK/CHOP/Bcl-2 pathways
BackgroundAutism spectrum disorder (ASD) is a neurodevelopmental disease characterized by repetitive behaviors and a lack of social communication. The role of probiotics, phytochemicals and their combination phytochemicals as treatment options for ASD is still under study.ObjectiveThis study aimed…
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Artikel Jurnal
Real-world data on the abuse potential of medications for the treatment of insomnia: a disproportionality analysis of the FAERS database
BackgroundInsomnia disorder is a chronic medical condition estimated to affect 12% of adults. The potential for abuse of hypnotics often contributes to physician reluctance to prescribe medications to treat insomnia as a chronic condition. This study examined the real-world abuse potential of…
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Artikel Jurnal
Targeted therapies in pediatric B-Cell acute lymphoblastic leukemia: mechanisms, efficacy, and future directions
BackgroundAcute lymphoblastic leukemia (ALL) is the most common hematologic malignancy in children and is characterized by rapid progression and, in some cases, a high risk of relapse. Targeted therapies have revolutionized treatment with greater specificity, reduced systemic toxicity and a better…
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Artikel Jurnal
Preparation, immunological and pharmacological effects of flavonoids in Scutellariae radix: a review
In traditional Chinese medicine theory, Scutellaria baicalensis Georgi [Lamiaceae; Scutellariae radix] (SR) is bitter and cold in nature. It enters the lung, gallbladder, spleen, large intestine, and small intestine meridians. It clears heat and dries dampness, purges fire and detoxifies, stops…
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Artikel Jurnal
The efficacy of artesunate in animal models of sepsis: a systematic review and meta-analysis
BackgroundSepsis is a life-threatening condition caused by a dysregulated host response to infection, characterized by biphasic immune dysregulation and high mortality rates. Artesunate (AS), a semisynthetic artemisinin derivative, has demonstrated broad pharmacological properties, yet its overall…
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Artikel Jurnal
Integrating traditional omics and AI-driven approaches for discovery and validation of novel MicroRNA biomarkers and therapeutic targets in thyroid cancer
BackgroundThe discovery of reliable biomarkers and therapeutic targets remains a critical challenge in thyroid cancer management. This study demonstrates the value of integrating traditional omics technologies with artificial intelligence approaches and single-cell validation to identify novel…
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Artikel Jurnal
A study on the availability of national centralized drug procurement in regions with different levels of economic development: an investigation and analysis of 31 provincial-level administrative regions in China
BackgroundChina is characterized by significant regional disparities in economic development levels. Accordingly, both the regional implementation effectiveness of the national centralized drug procurement (NCDP) policy and relevant influencing factors urgently require investigation, with the aim…
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Artikel Jurnal
Early treatment with nootkatone prevents pressure overload-induced ventricular remodeling and heart failure
Heart failure (HF) represents the clinical end stage of most cardiovascular diseases and remains a major cause of mortality, morbidity, and poor quality of life worldwide. In the present study, we use a mouse model induced by abdominal aortic constriction (AAC) that mimics HF and evaluate the…
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Artikel Jurnal
Therapeutic strategies for KRAS G12C-mutant non-small cell lung cancer: from bench to bedside and beyond
KRAS is one of the most frequently mutated oncogenes in non-small cell lung cancer (NSCLC), particularly in lung adenocarcinoma, with mutation rates ranging from 15% to 25%. Historically considered “undruggable,” KRAS has recently become a viable therapeutic target with the development of selective…
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