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Artikel Jurnal
A curriculum-integrated learning experience linking experimental pharmacology, cell culture and Nrf2-related gene expression analysis in undergraduate biotechnology education
BackgroundUndergraduate biotechnology education requires integrated, experiential approaches that help students connect pharmacological modulation, cellular models, molecular analysis and data interpretation within coherent biological problems. This study describes and evaluates a…
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Artikel Jurnal
Current and emerging drugs for Parkinson’s disease: mechanisms, clinical evidence, and future directions
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuronal loss and α-synuclein pathology, resulting in disabling motor and non-motor symptoms. Pharmacotherapy remains the cornerstone of PD management, yet current treatments are largely symptomatic…
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Artikel Jurnal
Efficacy and safety of sintilimab combined with histology-specific chemotherapy in advanced NSCLC: a real-world retrospective study
ObjectivesThis study aimed to evaluate whether the clinical efficacy of first-line sintilimab combined with histology-specific chemotherapy (adenocarcinoma [ADC]: pemetrexed/platinum [Pem/Plat]; squamous cell carcinoma [SqCC]: paclitaxel/platinum [Pac/Plat]) differs by histological subtype in…
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Artikel Jurnal
Immune checkpoint inhibitor-related cardiotoxicity: a cellular pharmacology perspective on susceptibility and resistance
Immune checkpoint inhibitors (ICIs) have reshaped the treatment landscape of cancer, yet their clinical benefit is accompanied by a distinct spectrum of immune-related toxicities. Among these, cardiotoxicity remains uncommon but clinically consequential because it can evolve quickly, presents with…
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Artikel Jurnal
Chemotherapy-induced peripheral neuropathy associated with docetaxel or nab-paclitaxel among patients with lung cancer: a prospective dual-center cohort study
ObjectiveTo compare the distinct clinical manifestations of chemotherapy-induced peripheral neuropathy (CIPN) in patients with different types of lung cancer treated with docetaxel or nab-paclitaxel, as well as to evaluate the post-intervention symptom improvement following therapeutic…
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Artikel Jurnal
Quercetin as a multifaceted neuroprotective agent against cerebral ischaemia-reperfusion injury: mechanisms and therapeutic potential
Cerebral ischaemia-reperfusion injury (CIRI) is a significant contributor to neurological dysfunction following ischemic stroke, involving multiple pathological mechanisms such as immune disorder, oxidative stress, inflammatory response, and apoptosis. Quercetin, a flavonoid compound widely present…
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Artikel Jurnal
Efficacy and safety of nab-paclitaxel in advanced or recurrent small cell lung cancer: a single-arm meta-analysis
BackgroundAlthough various effective agents used as second- and third-line treatments for advanced or recurrent small cell lung cancer have improved overall survival, the optimal therapeutic regimen remains controversial. Previous studies have shown that albumin-bound paclitaxel exhibits favorable…
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Artikel Jurnal
Dahuang-mudanpi decoction mitigates ALI/ARDS pulmonary inflammation via multi-target regulation of HMGB1
BackgroundAcute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe inflammatory conditions with high mortality and limited treatment options. Targeting pulmonary inflammation is a critical strategy for improving clinical outcomes. This study was performed to investigate the…
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Artikel Jurnal
Off-label prescribing in ophthalmology: a retrospective analysis
Off-label practice is often needed in ophthalmology, due to the limited number of drugs approved to treat several ocular diseases and to manage challenging ocular surgeries. The aim was to analyze the off-label drug prescriptions issued from January 2014 to December 2024 at the Department of…
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Artikel Jurnal
From heart to brain: a Case Report of individualized antithrombotic management for left ventricular thrombus and stroke in a young patient with acute myocardial infarction
BackgroundLeft ventricular thrombus (LVT) is a serious complication of acute myocardial infarction (AMI), conferring a high risk of systemic embolism. The management of LVT becomes exceedingly challenging when complicated by acute ischemic stroke and recent percutaneous coronary intervention (PCI)…
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Artikel Jurnal
Polydopamine–polyethylene glycol–liproxstatin-1 nanoparticles inhibit ferroptosis for enhanced treatment of neutrophilic asthma
Ferroptosis is an iron-dependent programmed cell death mechanism triggered by the accumulation of lipid-based reactive oxygen species (ROS). It is closely implicated in the pathogenesis of asthma. Liproxstatin-1 (LIP-1) is a ferroptosis inhibitor that is beneficial for treating neutrophilic asthma…
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Artikel Jurnal
Impact of oral bacterial lysates on asthma control and immune parameters in children: evidence from an updated systematic review and meta-analysis of randomized trials
BackgroundThe role of oral bacterial lysates (OBLs) as adjuvant immunomodulatory therapy in pediatric asthma requires clarification. This systematic review and meta-analysis evaluates their efficacy and safety.MethodsWe searched eight databases for randomized controlled trials (RCTs) in children…
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Artikel Jurnal
In-vivo antidiarrheal activity of aqueous and hydroethanolic extracts of Anacardium occidentale and Khaya senegalensis used in Benin (West Africa) in a castor oil-induced diarrhea model traditionally
BackgroundThe management of diarrheal diseases involves the use of medicinal plants, particularly in developing countries, where access to conventional treatments remains limited.MethodsThe study evaluated the in-vivo antidiarrheal activity of aqueous and hydroethanolic extracts of Khaya…
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Artikel Jurnal
Safety of high-dose dual therapy for Helicobacter pylori eradication in patients with varying degrees of metabolic associated fatty liver disease
ObjectivesTo evaluate the safety and efficacy of high-dose dual therapy (HDDT) for Helicobacter pylori (H. pylori) eradication in patients with varying degrees of metabolic associated fatty liver disease (MAFLD)MethodsA total of 91 patients diagnosed with MAFLD complicated by H. pylori infection at…
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Artikel Jurnal
Pharmacogenomic impact and genetic architecture of toxicity in pediatric acute lymphoblastic leukemia induction therapy: an exploratory modeling approach
Induction chemotherapy for pediatric Acute Lymphoblastic Leukemia (ALL) is highly curative but accompanied by a severe toxicity profile. Evaluating the genetic susceptibility to these adverse events could inform hypothesis-generating risk stratification. In this exploratory retrospective cohort…
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Artikel Jurnal
Immunomodulatory effects of Yang He decoction on cyclophosphamide-induced immunosuppression in mice: restoration of immune organ integrity and cytokine balance
ObjectiveTo evaluate the protective effects and potential mechanisms of Yang He decoction (YHD), a classic traditional Chinese medicine formula, against cyclophosphamide (CTX)-induced immunosuppression in mice.MethodsAn immunosuppression model was established in Kunming mice via intraperitoneal…
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Artikel Jurnal
Formulation of hispidulin-loaded sodium carboxymethyl cellulose nanoparticles: characterisation, biological activities and molecular insights
BackgroundHispidulin is a bioactive flavonoid with promising antioxidant and anticancer properties; however, its poor aqueous solubility and stability limit its usage in therapeutic application. This study aimed to develop a suitable nanocarrier system to enhance its bioavailability and biological…
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Artikel Jurnal
Prediction model of thrombocytopenia on patients using linezolid: a ranked-based covariate selection with multi-center data
BackgroundThrombocytopenia is a common adverse reaction of linezolid, often leading to severe complications. It is challenging to externally validate directly apply developed in other countries. We aim to develop and validate a risk prediction model of linezolid-associated thrombocytopenia (LAT)…
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Artikel Jurnal
Filling the mechanistic and methodological gaps for predicting cytokine release syndrome in humans
Cytokine release syndrome (CRS) is a severe immune-mediated toxicity frequently associated with immunotherapies such as CAR-T cells and bispecific T-cell engagers. Predicting CRS in humans remains difficult because current animal models and in vitro systems do not adequately capture the complex…
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Artikel Jurnal
Mangiferin alleviates metabolic-associated fatty liver disease by modulating gut microbiota and FXR signaling pathway to regulate bile acid metabolism
BackgroundMetabolic-associated fatty liver disease (MAFLD) is characterized by excessive hepatic lipid accumulation, with limited safe and effective therapeutic options currently available. Previous studies have demonstrated that mangiferin (MAN) alleviates nonalcoholic fatty liver disease via…
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